scholarly journals Munc18-2 is required for Syntaxin 11 Localization on the Plasma Membrane in Cytotoxic T-Lymphocytes

Traffic ◽  
2015 ◽  
Vol 16 (12) ◽  
pp. 1330-1341 ◽  
Author(s):  
Nele M.G. Dieckmann ◽  
Yvonne Hackmann ◽  
Maurizio Aricò ◽  
Gillian M. Griffiths
Keyword(s):  
Plasma Membrane ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Syntaxin 11

scholarly journals Endocytosing the death sentence

2003 ◽  
Vol 160 (2) ◽  
pp. 155-156 ◽  
Author(s):  
Gillian M. Griffiths
Keyword(s):  
Plasma Membrane ◽  
Immune System ◽  
T Lymphocytes ◽  
Natural Killer ◽  
Cytotoxic T Lymphocytes ◽  
Target Cell ◽  
Critical Role ◽  
Death Sentence ◽  
Controversial Issues ◽  
Mannose 6 Phosphate

A series of recent studies have suggested that endocytosis of the mannose-6-phosphate receptor (MPR)**Abbreviations used in this paper: CTL, cytotoxic T lymphocytes; MPR, mannose-6-phosphate receptor; NK, natural killer. might play a critical role in delivering the death signal to cells targeted for destruction by the immune system (for review see Barry and Bleackley, 2002). These studies have raised a number of controversial issues regarding the trafficking of proteins from the plasma membrane of the target cell to their substrates in the cytosol. In this issue, Trapani and colleagues examine the death of cells in which endocytosis of the MPR is blocked and show that the death signal is delivered effectively in the absence of MPR endocytosis (Trapani et al., 2002, this issue). How then is the death sentence delivered?

scholarly journals Secondary induction of cytotoxic T lymphocytes with solubilized syngeneic tumor cell plasma membranes.

1978 ◽  
Vol 148 (5) ◽  
pp. 1435-1439 ◽  
Author(s):  
O Alaba ◽  
L W Law
Keyword(s):  
Plasma Membrane ◽  
T Lymphocytes ◽  
Tumor Cell ◽  
Cytotoxic T Lymphocytes ◽  
Plasma Membranes ◽  
Effector Cells ◽  
Syngeneic Tumor ◽  
Cell Plasma

Secondary induction of in vitro cytotoxic T lymphocytes in a syngeneic system has been achieved with plasma membrane, both in the particulate and solubilized forms. Both the induction and the lytic phases were shown to be immunologically specific. The effector cells generated were completely susceptible to treatment with anti-theta antibody and complement, suggesting that they are T lymphocytes.

Strategies for Tumor Elimination by Cytotoxic T Lymphocytes

1998 ◽  
Vol 18 (1-2) ◽  
pp. 47-54 ◽  
Author(s):  
Linda A. Sherman ◽  
Matthias Theobald ◽  
David Morgan ◽  
Javier Hernandez ◽  
Igor Bacik ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes
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