scholarly journals Caffeoylquinic acids: Chemistry, biosynthesis, occurrence, analytical challenges, and bioactivity

2021 ◽  
Author(s):  
Armando Alcazar Magana ◽  
Naofumi Kamimura ◽  
Amala Soumyanath ◽  
Jan F. Stevens ◽  
Claudia S. Maier
Keyword(s):  
Caffeoylquinic Acids

Caffeoylquinic Acids Rich versus Poor Fractions of Gynura procumbens: Their Comparative Antihyperlipidemic and Antioxidant Potential

2018 ◽  
Vol 18 (14) ◽  
pp. 1132-1140 ◽  
Author(s):  
Kisantini Murugesu ◽  
Vikneswaran Murugaiyah ◽  
Sultan A.M. Saghir ◽  
Mohd. Zaini Asmawi ◽  
Amirin Sadikun
Keyword(s):  
Antioxidant Potential ◽  
Caffeoylquinic Acids

scholarly journals Quantification of Major Bioactive Constituents, Antioxidant Activity, and Enzyme Inhibitory Effects of Whole Coffee Cherries (Coffea arabica) and Their Extracts

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4306
Author(s):  
Boris Nemzer ◽  
Diganta Kalita ◽  
Nebiyu Abshiru
Keyword(s):  
Antioxidant Activity ◽  
Coffea Arabica ◽  
Digestive Enzymes ◽  
Chlorogenic Acids ◽  
Inhibitory Effects ◽  
Bioactive Constituents ◽  
Caffeoylquinic Acids ◽  
Dicaffeoylquinic Acid ◽  
Ic50 Values ◽  
Control Of Diabetes

Coffee cherry is a rich source of chlorogenic acids (CGAs) and caffeine. In this study we examined the potential antioxidant activity and enzyme inhibitory effects of whole coffee cherries (WCC) and their two extracts on α-amylase, α-glucosidase and acetylcholinesterase (AChE) activities, which are targets for the control of diabetes and Alzheimer’s diseases. Whole coffee cherry extract 40% (WCCE1) is rich in chlorogenic acid compounds, consisting of a minimum of 40% major isomers, namely 3-caffeoylquinic acids, 4-caffeoylquinic acids, 5-caffeoylquinic acids, 3,4-dicaffeoylquinic acid, 3,5-dicaffeoylquinic acid, 4,5-dicaffeoylquinic acid, 4-feruloylquinc acid, and 5-feruloylquinc acid. Whole coffee cherry extract 70% (WCCE2) is rich in caffeine, with a minimum of 70%. WCCE1 inhibited the activities of digestive enzymes α-amylase and α-glucosidase, and WCCE2 inhibited acetylcholinesterase activities with their IC50 values of 1.74, 2.42, and 0.09 mg/mL, respectively. Multiple antioxidant assays—including DPPH, ABTS, FRAP, ORAC, HORAC, NORAC, and SORAC—demonstrated that WCCE1 has strong antioxidant activity.

scholarly journals An Insight into Kiwiberry Leaf Valorization: Phenolic Composition, Bioactivity and Health Benefits

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2314
Author(s):  
Ana Margarida Silva ◽  
Diana Pinto ◽  
Iva Fernandes ◽  
Victor de Freitas ◽  
María de la Luz Cádiz-Gurrea ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Plant Material ◽  
Dry Weight ◽  
Alcoholic Extract ◽  
Phenolic Profile ◽  
Hydroalcoholic Extract ◽  
Caffeoylquinic Acids ◽  
Solar Exposure ◽  
Assisted Extraction ◽  
Phenolic And Flavonoid

During kiwiberry production, different by-products are generated, including leaves that are removed to increase the fruit’s solar exposure. The aim of this work was to extract bioactive compounds from kiwiberry leaf by employing microwave-assisted extraction (MAE). Compatible food solvents (water and ethanol) were employed. The alcoholic extract contained the highest phenolic and flavonoid contents (629.48 mg of gallic acid equivalents (GAE) per gram of plant material on dry weight (dw) (GAE/g dw) and 136.81 mg of catechin equivalents per gram of plant material on dw (CAE/g dw), respectively). Oppositely, the hydroalcoholic extract achieved the highest antioxidant activity and scavenging activity against reactive oxygen and nitrogen species (IC50 = 29.10 μg/mL for O2•−, IC50 = 1.87 μg/mL for HOCl and IC50 = 1.18 μg/mL for •NO). The phenolic profile showed the presence of caffeoylquinic acids, proanthocyanidin, and quercetin in all samples. However, caffeoylquinic acids and quercetin were detected in higher amounts in the alcoholic extract, while proanthocyanidins were prevalent in the hydroalcoholic extract. No adverse effects were observed on Caco-2 viability, while the highest concentration (1000 µg/mL) of hydroalcoholic and alcoholic extracts conducted to a decrease of HT29-MTX viability. These results highlight the MAE potentialities to extract bioactive compounds from kiwiberry leaf.

scholarly journals Heavy-Metal Contents and the Impact of Roasting on Polyphenols, Caffeine, and Acrylamide in Specialty Coffee Beans

Foods ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1310
Author(s):  
Matúš Várady ◽  
Sylwester Ślusarczyk ◽  
Jana Boržíkova ◽  
Katarína Hanková ◽  
Michaela Vieriková ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Heavy Metal ◽  
Dry Matter ◽  
Green Beans ◽  
Caffeoylquinic Acids ◽  
Coffee Beans ◽  
Metal Contents ◽  
Specialty Coffee ◽  
Quantitative Analyses ◽  
The Impact

The aim of this study was to determine the effect of roasting on the contents of polyphenols (PPH), acrylamide (AA), and caffeine (CAF) and to analyze heavy metals in specialty coffee beans from Colombia (COL) and Nicaragua (NIC). Samples of NIC were naturally processed and COL was fermented anaerobically. Green beans from COL (COL-GR) and NIC (NIC-GR) were roasted at two levels, light roasting (COL-LIGHT and NIC-LIGHT) and darker roasting (COL-DARK and NIC-DARK), at final temperatures of 210 °C (10 min) and 215 °C (12 min), respectively. Quantitative analyses of PPH identified caffeoylquinic acids (CQA), feruloylquinic acids, and dicaffeoylquinic acids. Isomer 5-CQA was present at the highest levels and reached 60.8 and 57.7% in COL-GR and NIC-GR, 23.4 and 29.3% in COL-LIGHT and NIC-LIGHT, and 18 and 24.2% in COL-DARK and NIC-DARK, respectively, of the total PPH. The total PPH contents were highest in COL-GR (59.76 mg/g dry matter, DM). Roasting affected the contents of PPH, CAF, and AA (p < 0.001, p < 0.011 and p < 0.001, respectively). Nickel and cadmium contents were significantly higher in the COL-GR than in the NIC-GR beans. Darker roasting decreased AA content, but light roasting maintained similar amounts of CAF and total PPH.

scholarly journals Pro-Apoptotic Activity of Artichoke Leaf Extracts in Human HT-29 and RKO Colon Cancer Cells

2021 ◽  
Vol 18 (8) ◽  
pp. 4166
Author(s):  
Milena Villarini ◽  
Mattia Acito ◽  
Raffaella di Vito ◽  
Samuele Vannini ◽  
Luca Dominici ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Chlorogenic Acid ◽  
Cancer Cells ◽  
Herbaceous Plant ◽  
Colon Cancer Cells ◽  
Leaf Extracts ◽  
Caffeoylquinic Acids ◽  
Induction Of Apoptosis ◽  
Ht 29

(1) Background: Cynara cardunculus L. subsp. scolymus (L.) Hegi, popularly known as artichoke, is an herbaceous plant belonging to the Asteraceae family. Artichoke leaf extracts (ALEs) have been widely used in traditional medicine because of their hepatoprotective, cholagogic, hypoglycaemic, hypolipemic and antibacterial properties. ALEs are also recognized for their antioxidative and anti-inflammatory activities. In this study, we evaluated the cytotoxic, genotoxic, and apoptotic activities, as well as effect on cell growth of ALEs on human colon cancer HT-29 and RKO cells. HT-29 and RKO cells exhibit a different p53 status: RKO cells express the wild-type protein, whereas HT-29 cells express a p53-R273H contact mutant. (2) Methods: Four different ALEs were obtained by sequential extraction of dried artichoke leaves; ALEs were characterized for their content in chlorogenic acid, cynaropicrin, and caffeoylquinic acids. HT-29 and RKO cells were used for in vitro testing (i.e., cytotoxicity and genotoxicity assessment, cell cycle analysis, apoptosis induction). (3) Results: Two out of the four tested ALEs showed marked effects on cell vitality toward HT-29 and RKO tumour cells. The effect was accompanied by a genotoxic activity exerted at a non-cytotoxic concentrations, by a significant perturbation of cell cycle (i.e., with increase of cells in the sub-G1 phase), and by the induction of apoptosis. (4) Conclusions: ALEs rich in cynaropicrin, caffeoylquinic acids, and chlorogenic acid showed to be capable of affecting HT-29 and RKO colon cancer cells by inducing favourable biological effects: cell cycle perturbation, activation of mitochondrial dependent pathway of apoptosis, and the induction of genotoxic effects probably mediated by the induction of apoptosis. Taken together, these results weigh in favour of a potential cancer chemotherapeutic activity of ALEs.

scholarly journals Caffeoylquinic acids from antiplasmodial active extract of Xanthium cavanillesii fruits and their molecular modelling studies

2016 ◽  
Vol 31 (6) ◽  
pp. 729-733 ◽  
Author(s):  
Alex Gutterres Taranto ◽  
Sônia Carine Cova Costa ◽  
Franco Henrique Andrade Leite ◽  
Matheus Santos de Sá ◽  
Milena Botelho Pereira Soares ◽  
...  
Keyword(s):  
Molecular Modelling ◽  
Caffeoylquinic Acids ◽  
Molecular Modelling Studies ◽  
Modelling Studies

Single-laboratory validation for the determination of caffeic acid and seven caffeoylquinic acids in sweet potato leaves

2014 ◽  
Vol 78 (12) ◽  
pp. 2073-2080 ◽  
Author(s):  
Kazunori Sasaki ◽  
Tomoyuki Oki ◽  
Toru Kobayashi ◽  
Yumi Kai ◽  
Shigenori Okuno
Keyword(s):  
Caffeic Acid ◽  
Sweet Potato ◽  
Caffeoylquinic Acids ◽  
Single Laboratory ◽  
Sweet Potato Leaves

scholarly journals Antimicrobial and Efflux Pump Inhibitory Activity of Caffeoylquinic Acids from Artemisia absinthium against Gram-Positive Pathogenic Bacteria

PLoS ONE ◽  
2011 ◽  
Vol 6 (4) ◽  
pp. e18127 ◽  
Author(s):  
Yiannis C. Fiamegos ◽  
Panagiotis L. Kastritis ◽  
Vassiliki Exarchou ◽  
Haley Han ◽  
Alexandre M. J. J. Bonvin ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Pathogenic Bacteria ◽  
Efflux Pump ◽  
Artemisia Absinthium ◽  
Gram Positive ◽  
Caffeoylquinic Acids

Caffeoylquinic acids from Pterocaulon virgatum and Pluchea sagittalis

1979 ◽  
Vol 18 (12) ◽  
pp. 2052 ◽  
Author(s):  
Virginia S. Martino ◽  
Silvia L. Debenedetti ◽  
Jorge D. Coussio
Keyword(s):  
Caffeoylquinic Acids
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