scholarly journals Different mutational function of low‐ and high‐linear energy transfer heavy‐ion irradiation demonstrated by whole‐genome resequencing of Arabidopsis mutants

2017 ◽  
Vol 92 (6) ◽  
pp. 1020-1030 ◽  
Author(s):  
Yusuke Kazama ◽  
Kotaro Ishii ◽  
Tomonari Hirano ◽  
Taeko Wakana ◽  
Mieko Yamada ◽  
...  
1998 ◽  
Vol 149 (2) ◽  
pp. 128 ◽  
Author(s):  
G. Baldacchino ◽  
D. Le Parc ◽  
B. Hickel ◽  
M. Gardès-Albert ◽  
Z. Abedinzadeh ◽  
...  

2017 ◽  
Vol 58 (6) ◽  
pp. 803-808 ◽  
Author(s):  
Yoshiya Furusawa ◽  
Mizuho Nakano-Aoki ◽  
Yoshitaka Matsumoto ◽  
Ryoichi Hirayama ◽  
Alisa Kobayashi ◽  
...  

Abstract The quality of the sublethal damage (SLD) after irradiation with high–linear energy transfer (LET) ion beams was investigated with low-LET photons. Chinese hamster V79 cells and human squamous carcinoma SAS cells were first exposed to a priming dose of different ion beams at different LETs at the Heavy Ion Medical Accelerator in the Chiba facility. The cells were kept at room temperature and then exposed to a secondary test dose of X-rays. Based on the repair kinetics study, the surviving fraction of cells quickly increased with the repair time, and reached a plateau in 2–3 h, even when cells had received priming monoenergetic high-LET beams or spread-out Bragg peak beams as well as X-ray irradiation. The shapes of the cell survival curves from the secondary test X-rays, after repair of the damage caused by the high-LET irradiation, were similar to those obtained from cells exposed to primary X-rays only. Complete SLD repairs were observed, even when the LET of the primary ion beams was very high. These results suggest that the SLD caused by high-LET irradiation was repaired well, and likewise, the damage caused by the X-rays. In cells where the ion beam had made a direct hit in the core region in an ion track, lethal damage to the domain was produced, resulting in cell death. On the other hand, in domains that had received a glancing hit in the low-LET penumbra region, the SLD produced was completely repaired.


CYTOLOGIA ◽  
2021 ◽  
Vol 86 (4) ◽  
pp. 317-322
Author(s):  
Ayaka Matsuta ◽  
Takahiro Mayuzumi ◽  
Hajime Katano ◽  
Masanori Hatashita ◽  
Keiichi Takagi ◽  
...  

2002 ◽  
Vol 82 (11) ◽  
pp. 2333-2339
Author(s):  
G. Schumacher ◽  
R. C. Birtcher ◽  
D. P. Renusch ◽  
M. Grimsditch ◽  
L. E. Rehn

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