scholarly journals MHF 1 plays F anconi anaemia complementation group M protein ( FANCM )‐dependent and FANCM ‐independent roles in DNA repair and homologous recombination in plants

2014 ◽  
Vol 78 (5) ◽  
pp. 822-833 ◽  
Author(s):  
Natalie J. Dangel ◽  
Alexander Knoll ◽  
Holger Puchta
Keyword(s):  
Dna Repair ◽  
Homologous Recombination ◽  
Complementation Group ◽  
M Protein

Emerging roles for centromere-associated proteins in DNA repair and genetic recombination

2013 ◽  
Vol 41 (6) ◽  
pp. 1726-1730 ◽  
Author(s):  
Fekret Osman ◽  
Matthew C. Whitby
Keyword(s):  
Dna Repair ◽  
Homologous Recombination ◽  
Genetic Recombination ◽  
Current Knowledge ◽  
Complementation Group ◽  
Histone Fold ◽  
Centromere Proteins ◽  
Associated Proteins ◽  
And Function ◽  
Dna Translocase

Centromere proteins CENP-S and CENP-X are members of the constitutive centromere-associated network, which is a conserved group of proteins that are needed for the assembly and function of kinetochores at centromeres. Intriguingly CENP-S and CENP-X have alter egos going by the names of MHF1 (FANCM-associated histone-fold protein 1) and MHF2 respectively. In this guise they function with a DNA translocase called FANCM (Fanconi’s anemia complementation group M) to promote DNA repair and homologous recombination. In the present review we discuss current knowledge of the biological roles of CENP-S and CENP-X and how their dual existence may be a common feature of CCAN (constitutive centromere-associated network) proteins.

scholarly journals ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability

iScience ◽  
2021 ◽  
pp. 102534
Author(s):  
Shibin Xu ◽  
Xingxuan Wu ◽  
Peipei Wang ◽  
Sheng-Li Cao ◽  
Bin Peng ◽  
...  
Keyword(s):  
Dna Repair ◽  
Homologous Recombination

scholarly journals RAP80 and BRCA1 PARsylation protect chromosome integrity by preventing retention of BRCA1-B/C complexes in DNA repair foci

2020 ◽  
Vol 117 (4) ◽  
pp. 2084-2091
Author(s):  
Jekaterina Vohhodina ◽  
Kimberly J. Toomire ◽  
Sarah A. Petit ◽  
Goran Micevic ◽  
Geeta Kumari ◽  
...  
Keyword(s):  
Dna Repair ◽  
Homologous Recombination ◽  
Complex Formation ◽  
Illegitimate Recombination ◽  
Adp Ribosylation ◽  
Chromosomal Disorder ◽  
Nuclear Foci ◽  
Simultaneous Loss ◽  
Chromosome Integrity ◽  
Focal Structures

BRCA1 promotes error-free, homologous recombination-mediated repair (HRR) of DNA double-stranded breaks (DSBs). When excessive and uncontrolled, BRCA1 HRR activity promotes illegitimate recombination and genome disorder. We and others have observed that the BRCA1-associated protein RAP80 recruits BRCA1 to postdamage nuclear foci, and these chromatin structures then restrict the amplitude of BRCA1-driven HRR. What remains unclear is how this process is regulated. Here we report that both BRCA1 poly-ADP ribosylation (PARsylation) and the presence of BRCA1-bound RAP80 are critical for the normal interaction of BRCA1 with some of its partners (e.g., CtIP and BACH1) that are also known components of the aforementioned focal structures. Surprisingly, the simultaneous loss of RAP80 and failure therein of BRCA1 PARsylation results in the dysregulated accumulation in these foci of BRCA1 complexes. This in turn is associated with the intracellular development of a state of hyper-recombination and gross chromosomal disorder. Thus, physiological RAP80-BRCA1 complex formation and BRCA1 PARsylation contribute to the kinetics by which BRCA1 HRR-sustaining complexes normally concentrate in nuclear foci. These events likely contribute to aneuploidy suppression.

scholarly journals A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M

2005 ◽  
Vol 37 (9) ◽  
pp. 958-963 ◽  
Author(s):  
Amom Ruhikanta Meetei ◽  
Annette L Medhurst ◽  
Chen Ling ◽  
Yutong Xue ◽  
Thiyam Ramsing Singh ◽  
...  
Keyword(s):  
Dna Repair ◽  
Fanconi Anemia ◽  
Complementation Group ◽  
Repair Protein ◽  
Dna Repair Protein ◽  
Human Ortholog

scholarly journals End-resection at DNA double-strand breaks in the three domains of life

2013 ◽  
Vol 41 (1) ◽  
pp. 314-320 ◽  
Author(s):  
John K. Blackwood ◽  
Neil J. Rzechorzek ◽  
Sian M. Bray ◽  
Joseph D. Maman ◽  
Luca Pellegrini ◽  
...  
Keyword(s):  
Dna Repair ◽  
Homologous Recombination ◽  
Strand Break ◽  
Double Strand Breaks ◽  
Dna Double Strand Breaks ◽  
Strand Breaks ◽  
Homologous Chromosomes ◽  
Domains Of Life ◽  
Strand Invasion ◽  
End Resection

During DNA repair by HR (homologous recombination), the ends of a DNA DSB (double-strand break) must be resected to generate single-stranded tails, which are required for strand invasion and exchange with homologous chromosomes. This 5′–3′ end-resection of the DNA duplex is an essential process, conserved across all three domains of life: the bacteria, eukaryota and archaea. In the present review, we examine the numerous and redundant helicase and nuclease systems that function as the enzymatic analogues for this crucial process in the three major phylogenetic divisions.

scholarly journals Survivin contributes to DNA repair by homologous recombination in breast cancer cells

2015 ◽  
Vol 155 (1) ◽  
pp. 53-63 ◽  
Author(s):  
Eloïse Véquaud ◽  
Grégoire Desplanques ◽  
Pascal Jézéquel ◽  
Philippe Juin ◽  
Sophie Barillé-Nion
Keyword(s):  
Breast Cancer ◽  
Dna Repair ◽  
Homologous Recombination ◽  
Cancer Cells ◽  
Breast Cancer Cells

scholarly journals SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination

Cell Reports ◽  
2017 ◽  
Vol 20 (8) ◽  
pp. 1921-1935 ◽  
Author(s):  
Waaqo Daddacha ◽  
Allyson E. Koyen ◽  
Amanda J. Bastien ◽  
PamelaSara E. Head ◽  
Vishal R. Dhere ◽  
...  
Keyword(s):  
Dna Repair ◽  
Homologous Recombination ◽  
Dna End Resection ◽  
End Resection

scholarly journals BET proteins regulate homologous recombination-mediated DNA repair: BRCAness and implications for cancer therapy

2018 ◽  
Vol 144 (4) ◽  
pp. 755-766 ◽  
Author(s):  
Catia Mio ◽  
Lorenzo Gerratana ◽  
Marco Bolis ◽  
Federica Caponnetto ◽  
Andrea Zanello ◽  
...  
Keyword(s):  
Dna Repair ◽  
Cancer Therapy ◽  
Homologous Recombination
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