Acute kidney injury in pregnancy and the use of non-steroidal anti-inflammatory drugs

2016 ◽  
Vol 18 (2) ◽  
pp. 127-135 ◽  
Author(s):  
Kate S Wiles ◽  
Anita Banerjee
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
In Pregnancy

scholarly journals Nonsteroidal Anti-Inflammatory Drugs Are an Important Cause of Acute Kidney Injury in Children

2013 ◽  
Vol 162 (6) ◽  
pp. 1153-1159.e1 ◽  
Author(s):  
Jason M. Misurac ◽  
Chad A. Knoderer ◽  
Jeffrey D. Leiser ◽  
Corina Nailescu ◽  
Amy C. Wilson ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Significant Acute Kidney Injury Due to Non-steroidal Anti-inflammatory Drugs: Inpatient Setting

2010 ◽  
Vol 3 (4) ◽  
pp. 1279-1285 ◽  
Author(s):  
Mehul Dixit ◽  
Thuy Doan ◽  
Rebecca Kirschner ◽  
Naznin Dixit
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Inpatient Setting ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Chronic heart failure and the frequency of taking nonsteroidal anti-inflammatory drugs: a register-based study on the possible risks

2020 ◽  
Vol 25 (1) ◽  
pp. 59-64 ◽  
Author(s):  
E. I. Tarlovskaya ◽  
Yu. V. Mikhailova
Keyword(s):  
Heart Failure ◽  
Acute Kidney Injury ◽  
Ejection Fraction ◽  
Kidney Injury ◽  
Outpatient Basis ◽  
Heart Failure Therapy ◽  
Nsaid Group ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Therapy Center

Aim. To study the frequency of taking nonsteroidal anti-inflammatory drugs (NSAIDs) and possible adverse events in patients with cardiovascular diseases and heart failure (HF) hospitalized in the Heart Failure Therapy Center (Nizhny Novgorod).Material and methods. According to the local register, the study included 336 patients (men — 156 and women — 180, average age — 71 (63; 80)), hospitalized in Heart Failure Therapy Center in Nizhny Novgorod from February 1 to November 1, 2019. Examination and treatment of patients was performed based on current clinical practice guidelines and standards. According to the results of echocardiography, HF with preserved ejection fraction was diagnosed in 70% of patients, HF with mid-range ejection fraction — in 20%, and HF with reduced ejection fraction — in 10%. Based on data on the outpatient NSAIDs taking, all participants were divided into 2 groups: NSAID+ (n=63) and NSAID(n=273).Results. Among hospitalized patients, 18,7% of patients took NSAIDs on an outpatient basis, without a doctor’s prescription, more often non-selective, mainly by mouth, for stopping arthralgia. The frequency of emergency hospitalizations due to acute HF decompensation depending on the NSAIDs taking did not significantly differ. In the NSAID+ group, acute kidney injury was diagnosed 3 times more often and 10 times more often when NSAIDs were taken ≥1 times a week. Anemia was diagnosed more often in the NSAID+ group, when taking NSAIDs ≥1 times a week. In the NSAID+ group, grade 2-4 anemia was significantly more often diagnosed.Conclusion. None of the patients took the recommended NSAIDs with a low cardiovascular risk. Patients taking NSAIDs were more likely to have a history of atrial fibrillation and acute cerebrovascular accident. Patients from the NSAID+ group had the higher incidence of acute kidney injury and anemia.

Non-steroidal anti-inflammatory drugs and risk of acute adverse renal outcomes in diabetes and diabetic kidney disease

2021 ◽  
pp. 1-10
Author(s):  
Cynthia Ciwei Lim ◽  
Hanis Bte Abdul Kadir ◽  
Ngiap Chuan Tan ◽  
Andrew Teck Wee Ang ◽  
Yong Mong Bee ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Primary Outcome ◽  
Statistical Significance ◽  
Kidney Injury ◽  
Singapore General Hospital ◽  
Nsaid Prescription ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

BACKGROUND: Individuals with diabetes mellitus (DM) may be susceptible to non-steroidal anti-inflammatory drug (NSAID) – induced acute kidney injury (AKI) but data on NSAID-related adverse renal events is sparse. We aimed to evaluate the risk of acute kidney injury and/or hyperkalemia after systemic NSAID among individuals with DM and diabetic chronic kidney disease (CKD). METHODS: Retrospective cohort study of 3896 adults with DM with incident prescriptions between July 2015 and December 2017 from Singapore General Hospital and SingHealth Polyclinics. Laboratory, hospitalization and medication data were retrieved from electronic medical records. The primary outcome was the incidence of AKI and/ or hyperkalemia within 30 days after prescription. RESULTS: AKI and/or hyperkalemia occurred in 13.5% of all DM and 15.8% of diabetic CKD. The association between systemic NSAID >14 days and 30-day risk of AKI and/or hyperkalemia failed to reach statistical significance in unselected DM (adjusted OR 1.62, 95% CI 0.99–2.65, p = 0.05) and diabetic CKD (adjusted OR 0.64, 95% CI 0.15–2.82, p = 0.64), but the odds of AKI and/or hyperkalemia were markedly and significantly increased when NSAID was prescribed with renin-angiotensin-aldosterone system (RAAS) blocker (adjusted OR 4.17, 95% CI 1.74–9.98, p = 0.001) or diuretic (adjusted OR 3.31, 95% CI 1.09–10.08, p = 0.04) and in the absence of diabetic CKD (adjusted OR 1.98, 95% CI 1.16–3.36, p = 0.01). CONCLUSION: NSAID prescription >14 days in individuals with DM with concurrent RAAS blockers or diuretics was associated with higher 30-day risk of AKI and/or hyperkalemia.

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