scholarly journals Regimen durability in HIV-infected children and adolescents initiating first-line antiretroviral therapy in a large public sector HIV cohort in South Africa

2018 ◽  
Vol 23 (6) ◽  
pp. 650-660
Author(s):  
Rachael Bonawitz ◽  
Alana T. Brennan ◽  
Lawrence Long ◽  
Timothy Heeren ◽  
Mhairi Maskew ◽  
...  
Keyword(s):  
South Africa ◽  
Antiretroviral Therapy ◽  
Public Sector ◽  
Children And Adolescents ◽  
First Line

Comparing effectiveness of first‐line antiretroviral therapy between peri‐urban and rural clinics in KwaZulu‐Natal, South Africa

HIV Medicine ◽  
2022 ◽  
Author(s):  
Jaysingh Brijkumar ◽  
Johnathan A. Edwards ◽  
Brent A. Johnson ◽  
Claudia Ordonez ◽  
Henry Sunpath ◽  
...  
Keyword(s):  
South Africa ◽  
Antiretroviral Therapy ◽  
First Line ◽  
Kwazulu Natal ◽  
Rural Clinics

scholarly journals First-line antiretroviral therapy after single-dose nevirapine exposure in South Africa: a cost-effectiveness analysis of the OCTANE trial

AIDS ◽  
2011 ◽  
Vol 25 (4) ◽  
pp. 479-492 ◽  
Author(s):  
Andrea L Ciaranello ◽  
Shahin Lockman ◽  
Kenneth A Freedberg ◽  
Michael Hughes ◽  
Jennifer Chu ◽  
...  
Keyword(s):  
South Africa ◽  
Single Dose ◽  
Cost Effectiveness ◽  
Antiretroviral Therapy ◽  
Cost Effectiveness Analysis ◽  
First Line ◽  
Effectiveness Analysis ◽  
Single Dose Nevirapine

Provision of antiretroviral therapy to children within the public sector of South Africa

2008 ◽  
Vol 102 (9) ◽  
pp. 905-911 ◽  
Author(s):  
Peter Bock ◽  
Andrew Boulle ◽  
Catherine White ◽  
Meg Osler ◽  
Brian Eley
Keyword(s):  
South Africa ◽  
Antiretroviral Therapy ◽  
Public Sector ◽  
The Public

scholarly journals Viremia, Resuppression, and Time to Resistance in Human Immunodeficiency Virus (HIV) Subtype C during First‐Line Antiretroviral Therapy in South Africa

2009 ◽  
Vol 49 (12) ◽  
pp. 1928-1935 ◽  
Author(s):  
Christopher J. Hoffmann ◽  
Salome Charalambous ◽  
John Sim ◽  
Joanna Ledwaba ◽  
Graham Schwikkard ◽  
...  
Keyword(s):  
South Africa ◽  
Human Immunodeficiency Virus ◽  
Antiretroviral Therapy ◽  
Subtype C ◽  
First Line ◽  
Immunodeficiency Virus

scholarly journals Estimated use of abacavir among adults and children enrolled in public sector antiretroviral therapy programmes in Gauteng, South Africa

2012 ◽  
Vol 13 (3) ◽  
pp. 134-137 ◽  
Author(s):  
D Evans ◽  
M Maskwe ◽  
C Heneger ◽  
I Sanne
Keyword(s):  
South Africa ◽  
Antiretroviral Therapy ◽  
Public Sector ◽  
Treatment Guidelines ◽  
Hiv Positive ◽  
Second Line ◽  
Gauteng Province ◽  
Paediatric Patients ◽  
Adults And Children ◽  
Second Line Antiretroviral Therapy

In South Africa, abacavir (ABC) is currently recommended as part of first- and second-line antiretroviral therapy (ART) for HIV-positive paediatric patients. Concerns about overprescribing of the drug, particularly to adults, led to an analysis of ABC use in public sector ART programmes. We investigated current prescription of the drug to adults and children accessing ART in 4 public sector programmes across Gauteng Province, South Africa. ABC was almost exclusively prescribed to children initiating ART and adults requiring regimen changes due to drug toxicities. Patterns of ABC use among HIV-positive paediatric patients followed national ART treatment guidelines on the application of the drug. Although ABC is commonly used in the private sector for adults, the current national ART treatment guidelines for adults and adolescents should include ABC as an alternative to standard first- or second-line ART.

scholarly journals Study protocol: Strengthening understanding of effective adherence strategies for first-line and second-line antiretroviral therapy (ART) in selected rural and urban communities in South Africa

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0261107
Author(s):  
Siphamandla Bonga Gumede ◽  
John Benjamin Frank de Wit ◽  
Willem Daniel Francois Venter ◽  
Samanta Tresha Lalla-Edward
Keyword(s):  
Public Health ◽  
South Africa ◽  
Systematic Review ◽  
Data Analysis ◽  
Antiretroviral Therapy ◽  
Meta Analysis ◽  
Secondary Data ◽  
Limpopo Province ◽  
Second Line ◽  
First Line

Multiple factors make adherence to antiretroviral therapy (ART) a complex process. This study aims to describe the barriers and facilitators to adherence for patients receiving first-line and second-line ART, identify different adherence strategies utilized and make recommendations for an improved adherence strategy. This mixed method parallel convergent study will be conducted in seven high volume public health facilities in Gauteng and one in Limpopo province in South Africa. The study consists of four phases; a retrospective secondary data analysis of a large cohort of patients on ART (using TIER.Net, an ART patient and data management system for recording and monitoring patients on ART and tuberculosis (TB)) from seven Johannesburg inner-city public health facilities (Gauteng province); a secondary data analysis of the Intensified Treatment Monitoring Accumulation (ITREMA) trial (a randomized control trial which ran from June 2015 to January 2019) conducted at the Ndlovu Medical Center (Limpopo province); in-depth interviews with people living with Human Immunodeficiency Virus (PLHIV) who are taking ART (in both urban and rural settings); and a systematic review of the impact of treatment adherence interventions for chronic conditions in sub-Saharan Africa. Data will be collected on demographics, socio-economic status, treatment support, retention in care status, disclosure, stigma, clinical markers (CD4 count and viral load (VL)), self-reported adherence information, intrapersonal, and interpersonal factors, community networks, and policy level factors. The systematic review will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) reporting and Population, Interventions, Comparisons and Outcomes (PICO) criteria. Analyses will involve tests of association (Chi-square and t-test), thematic analysis (deductive and inductive approaches) and network meta-analysis. Using an integrated multilevel socio-ecological framework this study will describe the factors associated with adherence for PLHIV who are taking first-line or second-line ART. Implementing evidence-based adherence approaches, when taken up, will improve patient’s overall health outcomes. Our study results will provide guidance regarding context-specific intervention strategies to improve ART adherence.

scholarly journals Predictors of switch to and early outcomes on third-line antiretroviral therapy at a large public-sector clinic in Johannesburg, South Africa

2018 ◽  
Vol 15 (1) ◽  
Author(s):  
Denise Evans ◽  
Kamban Hirasen ◽  
Rebecca Berhanu ◽  
Given Malete ◽  
Prudence Ive ◽  
...  
Keyword(s):  
South Africa ◽  
Antiretroviral Therapy ◽  
Public Sector ◽  
Third Line

scholarly journals Virologic Failure Among Children Taking Lopinavir/Ritonavir-containing First-line Antiretroviral Therapy in South Africa

2015 ◽  
Vol 34 (2) ◽  
pp. 175-179 ◽  
Author(s):  
Tammy Meyers ◽  
Shobna Sawry ◽  
Jessica Y. Wong ◽  
Harry Moultrie ◽  
Francoise Pinillos ◽  
...  
Keyword(s):  
South Africa ◽  
Antiretroviral Therapy ◽  
Virologic Failure ◽  
First Line
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