scholarly journals Cardiopulmonary ultrasound for critically ill adults improves diagnostic accuracy in a resource-limited setting: the AFRICA trial

2017 ◽  
Vol 22 (12) ◽  
pp. 1599-1608 ◽  
Author(s):  
Torben K. Becker ◽  
Chelsea A. Tafoya ◽  
Maxwell Osei-Ampofo ◽  
Matthew J. Tafoya ◽  
Ross A. Kessler ◽  
...  
2018 ◽  
Vol 23 (3) ◽  
pp. 100-103
Author(s):  
Ajak Makor ◽  
Josephat Jombwe ◽  
Moses Galukande ◽  
Alex E. Elobu

Background: The management of acute appendicitis remains challenging with high peri-operative morbidity and mortality due diagnostic delay or high negative appendicetomy rates due to aggressive surgical approaches. CT scan is accurate for pre-operative diagnosis but not available or affordable in all settings. There remains a need for an affordable yet accurate tool for diagnosing acute appendicitis in the resource limited setting. Methods: To determine the diagnostic accuracy of Tzanakis score in the preoperative evaluation of patients with acute appendicitis, we conducted a descriptive cross-sectional study at Mulago Hospital in Kampala, Uganda. Eligible consenting patients diagnosed with acute appendicitis consecutively underwent Tzanakis scoring and appendicectomy. Appencieal samples were sent for histological examination. Sensitivity, specificity, positive predictive value, negative predictive values, and diagnostic accuracy of the Tzanakis scoring system were calculated, relative to histological examination. Results: We enrolled 160 participants of mean age 30.4 years with male:female ratio of 2:1. The Tzanakis score had sensitivity of100% (95% CI 98-100), positive predictive value 97 % (95% CI 95-99), specificity of 64% (95% CI 31-89), negative predictive value of 100%, and overall diagnostic accuracy of 98% with 3% negative appendectomy rate. Conclusions: The Tzanakis score is found to be a sensitive and specific tool that should be considered for preoperative diagnosis of acute appendicitis in resource limited settings. Keywords: appendicitis; appendicectomy; acute abdomen; diagnosis; Tzanakis score; Uganda 


2019 ◽  
Vol 48 (5-6) ◽  
pp. 241-249
Author(s):  
Maria C. Duggan ◽  
Madeline E. Morrell ◽  
Rameela Chandrasekhar ◽  
Annachiara Marra ◽  
Kwame Frimpong ◽  
...  

Background/Aim: The diagnostic accuracy of brief informant screening instruments to detect dementia in critically ill adults is unknown. We sought to determine the diagnostic accuracy of the 2- to 3-min Ascertain Dementia 8 (AD8) completed by surrogates in detecting dementia among critically ill adults suspected of having pre-existing dementia by comparing it to the Clinical Dementia Rating Scale (CDR). Methods: This substudy of BRAIN-ICU included a subgroup of 75 critically ill medical/surgical patients determined to be at medium risk of having pre-existing dementia (Informant Questionnaire on Cognitive Decline in the Elderly [IQCODE] score ≥3.3). We calculated the sensitivity, specificity, positive and negative predictive values (PPV and NPV), and AUC for the standard AD8 cutoff of ≥2 versus the reference standard CDR score of ≥1 for mild dementia. Results: By the CDR, 38 patients had very mild or no dementia and 37 had mild dementia or greater. For diagnosing mild dementia, the AD8 had a sensitivity of 97% (95% CI 86–100), a specificity of 16% (6–31), a PPV of 53% (40–65), an NPV of 86% (42–100), and an AUC of 0.738 (0.626–0.850). Conclusions: Among critically ill patients judged at risk for pre-existing dementia, the 2- to 3-min AD8 is highly sensitive and has a high NPV. These data indicate that the brief tool can serve to rule out dementia in a specific patient population.


2003 ◽  
Vol 29 (9) ◽  
pp. 1547-1554 ◽  
Author(s):  
Mark Hatherill ◽  
Zainab Waggie ◽  
Louis Reynolds ◽  
Andrew Argent

2020 ◽  
Vol 55 ◽  
pp. 56-63
Author(s):  
Theerapon Sukmark ◽  
Nuttha Lumlertgul ◽  
Kearkiat Praditpornsilpa ◽  
Kriang Tungsanga ◽  
Somchai Eiam-ong ◽  
...  

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