scholarly journals Implementation of 350-2500 nm diffuse reflectance spectroscopy and High-Performance Thin-Layer Chromatography to rapidly assess manufacturing consistency and quality of cotrimoxazole tablets in Tanzania

2015 ◽  
Vol 21 (1) ◽  
pp. 61-69
Author(s):  
Eliangiringa Kaale ◽  
Samuel M. Hope ◽  
David Jenkins ◽  
Thomas Layloff
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
High Performance ◽  
Diffuse Reflectance ◽  
Diffuse Reflectance Spectroscopy ◽  
Reflectance Spectroscopy ◽  
Layer Chromatography

scholarly journals Application of High-Performance, Thin-Layer Chromatography to Quality Control of Antimetabolite Analogue Infusion Bags

2001 ◽  
Vol 84 (4) ◽  
pp. 1296-1300 ◽  
Author(s):  
Laurent Perello ◽  
Sylvie Demirdjian ◽  
Alexandre Dory ◽  
Philippe Bourget
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
High Performance ◽  
Double Standard ◽  
Analytical Tool ◽  
Quality Program ◽  
Chemotherapy Infusion ◽  
Standard Calibration ◽  
Layer Chromatography

Abstract A global postproduction quality program was developed to secure chemotherapy infusion at the Gustave Roussy Institute. Despite rigorous procedures and computerized prescriptions, an analytical check was necessary to improve the quality of ready-to-use solutions of cytotoxic drugs in our Centralized Antineoplastics Reconstitution Unit. High-performance, thin-layer chromatography was selected as the analytical tool to assay 12 anticancer drugs. One of the analytical methods can separate 4 antimetabolite substances, i.e., fludarabine (FDB), cytarabine (CTB), gemcitabine (GTB), and fluorouracil (5 FU). For all infusion bags manufactured, up to 26 samples could be assayed per series using a double standard calibration (GTB and 5 FU).

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