scholarly journals Prescription patterns and treatment outcomes of MDR-TB patients treated within and outside the National Tuberculosis Programme in Pham Ngoc Thach hospital, Viet Nam

2014 ◽  
Vol 19 (9) ◽  
pp. 1076-1081 ◽  
Author(s):  
Nguyen B. Hoa ◽  
Pham H. Khanh ◽  
Nguyen V. Chinh ◽  
Cornelia M. Hennig
Keyword(s):  
Treatment Outcomes ◽  
Viet Nam ◽  
Prescription Patterns ◽  
National Tuberculosis Programme ◽  
National Tuberculosis ◽  
Tuberculosis Programme ◽  
Mdr Tb

Collaboration between private pharmacies and national tuberculosis programme: an intervention in Bolivia

2005 ◽  
Vol 10 (3) ◽  
pp. 246-250 ◽  
Author(s):  
M. L. Lambert ◽  
R. Delgado ◽  
G. Michaux ◽  
A. Vols ◽  
N. Speybroeck ◽  
...  
Keyword(s):  
National Tuberculosis Programme ◽  
National Tuberculosis ◽  
Tuberculosis Programme

Childhood TB in China: notification, characteristics and risk factors for outcomes, 2010–2017

2020 ◽  
Vol 24 (12) ◽  
pp. 1285-1293
Author(s):  
T. Li ◽  
Y. Ma ◽  
K. Liu ◽  
H. D. Shewade ◽  
H. Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Treatment Outcomes ◽  
Age Groups ◽  
Previous Treatment ◽  
Cross Sectional ◽  
Migrant Families ◽  
National Tuberculosis ◽  
Tuberculosis Programme ◽  
Childhood Tb ◽  
Cross Sectional Design

SETTING: China National Tuberculosis Programme, 2010–2017.OBJECTIVE: To describe the epidemiology of childhood (age < 15 years) TB, including treatment outcomes and risk factors for unfavourable outcomes and death.DESIGN: We used a cross-sectional design for the descriptive component and a cohort design for treatment outcomes and their risk factors (assessed using log binomial regression).RESULTS: Of 40 561 children, 77.7% (n = 31 529) were aged 10–14 years and 19.6% (n = 7931) were bacteriologically confirmed. Around 14% (n = 5827) belonged to migrant families (internal migration) and 4.0% (n = 1,642) were actively detected. Over 8 years, annual notification was consistently very low (<1%), and notification of bacteriologically confirmed TB decreased by half. Unfavourable outcomes were seen in 6% and deaths in 0.4%; there were no significant changes over the years. The independent predictors of unfavourable outcomes were active case finding and extrapulmonary TB. Children belonging to migrant family were more likely to die. Independent predictors of unfavourable outcomes as well as death were age < 5 years and previous treatment.CONCLUSION: China needs to address the issue of under-detection of childhood TB, especially in younger age groups. The risk factors identified require attention if China is to attain zero child TB deaths.

scholarly journals Tuberculosis treatment delays and associated factors within the Zimbabwe national tuberculosis programme

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Kudakwashe C Takarinda ◽  
Anthony D Harries ◽  
Barnet Nyathi ◽  
Mkhokheli Ngwenya ◽  
Tsitsi Mutasa-Apollo ◽  
...  
Keyword(s):  
Associated Factors ◽  
Tuberculosis Treatment ◽  
Treatment Delays ◽  
National Tuberculosis Programme ◽  
National Tuberculosis ◽  
Tuberculosis Programme

scholarly journals Compliance of St Joseph’s Hospital Roma, Lesotho with the National Tuberculosis Programme of Lesotho, 2007 and 2008

2014 ◽  
Vol 6 (1) ◽  
Author(s):  
Oladoyinbo O. Samuel ◽  
Pierre J.T. De Villiers
Keyword(s):  
Treatment Failure ◽  
Sputum Smear ◽  
Smear Microscopy ◽  
Sputum Smear Microscopy ◽  
X Ray ◽  
National Tuberculosis Programme ◽  
National Tuberculosis ◽  
Tuberculosis Programme ◽  
Chest X Ray ◽  
Smear Negative

Background: In 2009 Lesotho had an estimated TB prevalence of 696 cases/100 000 population − the 4th highest in the world. This epidemic was characterised by high rates of death, treatment failure and unknown treatment outcomes. These adverse outcomes were attributable to a high rate of TB and/or HIV co-infection and weaknesses in the implementation of Lesotho’s National Tuberculosis Programme (NTP). This study was conducted in St Joseph’s Hospital, Roma (SJHR) to assess the implementation of the NTP.Method: Records of 993 patients entered into the SJHR TB register between 2007 and 2008 were reviewed. Patients’ treatment details were extracted from the register, validated and analysed by STATA 10.0.Results: Of 993 patients registered: 88% were new patients, 37% were diagnosed on sputum smear microscopy alone, 35% were diagnosed on sputum smear microscopy with chest X-ray, whilst 25% were diagnosed on chest X-ray alone. In addition: 33% were sputum smear positive, 45% were sputum smear negative, and 22% had extra-pulmonary TB. As to treatment outcome: 26% were cured, 51% completed treatment, and 51% converted from sputum smear positive to sputum smear negative over six months, whilst 16% died. Regarding HIV, 77% of patients were tested for HIV and 59% had TB and/or HIV co-infection. Of ten NTP targets only the defaulter and treatment failure rate targets were met.Conclusion: Whilst only two out of ten NTP targets were met at SJHR in 2007–2008, improvements in TB case management were noted in 2008 which were probably due to the positive effects of audit on staff performance.

scholarly journals Conflict and tuberculosis in Sudan: a 10-year review of the National Tuberculosis Programme, 2004-2014

2018 ◽  
Vol 12 (1) ◽  
Author(s):  
Sara A. Hassanain ◽  
Jeffrey K. Edwards ◽  
Emilie Venables ◽  
Engy Ali ◽  
Khadiga Adam ◽  
...  
Keyword(s):  
National Tuberculosis Programme ◽  
National Tuberculosis ◽  
Tuberculosis Programme

scholarly journals Treatment success using novel and adapted treatment regimens in registered DR-TB children in Dushanbe, Tajikistan, 2013-2019

2021 ◽  
Vol 15 (09.1) ◽  
pp. 7S-16S
Author(s):  
Bobojon Pirmahmadzoda ◽  
Katrina Hann ◽  
Kristina Akopyan ◽  
Ruzanna Grigoryan ◽  
Evgenia Geliukh ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Treatment Success ◽  
Short Treatment ◽  
Female Ratio ◽  
Treatment Regimens ◽  
Tb Treatment ◽  
National Tuberculosis ◽  
Mdr Tb ◽  
Pediatric Tb ◽  
Culture Conversion

Introduction: Approximately 3% of all pediatric TB cases develop MDR-TB, with only 3–4% of such children receiving MDR-TB treatment. In Tajikistan, children as a proportion of all DR-TB in the country increased from 4.3 to 7.5% during 2013-2018. Despite limited evidence on the use of new anti-TB drugs in children, WHO has updated its guidelines for DR-TB treatment for children, and Tajikistan did so in 2013 and 2017. Novel and adapted regimens included individual regimens for RR/MDR, XDR (with and without Bedaquiline and Delamanid) and short treatment regimens with and without injectables. It is important to document the outcomes of the treatment regimens. Therefore, the aim of this study was to describe characteristics of children receiving different treatment regimens for DR-TB, the culture conversion and treatment outcomes. Methodology: Cohort study of children enrolled in DR-TB treatment by the National Tuberculosis Program in Dushanbe, Tajikistan, January 2013 to July 2019. Results: The study included 60 DR-TB children. The male to female ratio was 1:2 and mean age 13.6 years. Median time to culture conversion was 66 days [IQR:31-103; Range:2-232]. In children with treatment outcomes (N = 58), 93% had favorable outcomes. There were four children (7%) with unfavorable treatment outcomes, all of whom were female 15-17 years, on standard (RR/MDR) treatment during 2013-2015. Favorable outcomes by DR-TB type were 91%, 90%, and 100% in RR/MDR, PreXDR, and XDR-TB patients, respectively. Conclusions: All children enrolled after the introduction of modified guidelines for novel and adapted regimens for DR-TB showed positive TB treatment outcomes.

Epidemiology and risk factors for extrapulmonary tuberculosis in Lebanon

2020 ◽  
Vol 24 (4) ◽  
pp. 414-419
Author(s):  
L. O'Son ◽  
E. Hulland ◽  
S. T. Cookson ◽  
K. G. Castro ◽  
H. Yaacoub
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Trend Analysis ◽  
Extrapulmonary Tuberculosis ◽  
Syrian Refugees ◽  
National Tuberculosis Programme ◽  
National Tuberculosis ◽  
Tuberculosis Programme ◽  
Potential Impact

SETTING: Lebanon is a relatively low TB-burden country, but has a high proportion of extrapulmonary tuberculosis (EPTB). Concern has been expressed that Syrian-born refugees could add to the TB burden and rates of EPTB: since 2011, >1 000 000 Syrian refugees have entered Lebanon.OBJECTIVE: The Lebanese National Tuberculosis Programme (NTP) sought to identify factors for the high proportion of EPTB and to assess the potential impact of Syrian refugees.DESIGN: NTP line-listed data from 2014–2015 were analyzed with logistic regression identified risk factors for EPTB. A trend analysis for 2011–2015 assessed TB burden by nationality and site of TB.RESULTS: Of 1347 reported TB cases from 2014 to 2015, 507 (38%) were EPTB and 46% were Lebanese. In analysis limited to Lebanese-born, the proportion of EPTB cases was relatively stable, 47% in 2011 and 52% in 2015. Modeling identified risk factors for EPTB as being female (aOR 1.79, 95%CI 1.39–2.32) and 5–15 years old (aOR 3.31, 95%CI 1.47–7.45) compared with children aged <5 years. Between 2011 and 2015, the proportion of TB cases among Syrian-born increased from 3% in 2011 to 21% in 2015 (P < 0.001); however, the proportion of EPTB versus PTB cases among Syrians remained stable (P = 0.264).CONCLUSION: Syrian TB cases increased almost 10-fold in five years (2011–2015) but their contribution to EPTB did not change. The high proportion of EPTB in Lebanon and those aged 5–15 years merits further investigation.

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