Association between the length of storage of transfused leukoreduced red blood cell units and hospital‐acquired infections in critically ill children: A secondary analysis of the TRIPICU study

2021 ◽  
Author(s):  
Leah K. Flatman ◽  
Dean A. Fergusson ◽  
Jacques Lacroix ◽  
Thierry Ducruet ◽  
Jesse Papenburg ◽  
...  
Keyword(s):  
Blood Cell ◽  
Critically Ill ◽  
Red Blood Cell ◽  
Secondary Analysis ◽  
Critically Ill Children ◽  
Hospital Acquired Infections ◽  
Hospital Acquired

DOES CHLORHEXIDINE WIPE HELP IN REDUCING HOSPITAL ACQUIRED INFECTIONS (HAIS) AMONG CRITICALLY ILL CHILDREN ADMITTED TO A PAEDIATRIC INTENSIVE CARE UNIT?

2021 ◽  
pp. 35-37
Author(s):  
Madhan Kumar ◽  
Jolly Chandran ◽  
Pragathesh Pragathesh ◽  
Ebor Jacob Gnananayagam ◽  
Hema Paul ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Critically Ill ◽  
Paediatric Intensive Care Unit ◽  
Paediatric Intensive Care ◽  
Critically Ill Children ◽  
Intervention Period ◽  
Hospital Acquired Infections ◽  
Hospital Acquired ◽  
Historical Controls

OBJECTIVE: To determine the effect of chlorhexidine wipes in reducing the incidence of hospital acquired infections (HAIs) among critically ill children admitted in Paediatric Intensive Care Unit (PICU). METHODS: An interventional study, wherein enrolled children were wiped with chlorhexidine after routine bath. The incidence of HAIs were noted and compared with data from historical controls of previous year during the same period (pre-intervention). RESULTS: One hundred and ninety nine children in the intervention period were compared with 271 children from pre-intervention period. The numbers of ventilator-days were 777 and 696 respectively for the intervention period and pre-intervention periods. Incidence of ventilator associated pneumonia (VAP) reduced from 12.9/1000 ventilator-days in the pre-intervention period to 6.4/1000 ventilator-days in the intervention period (p=0.1). VAP prevalence was 3.3% in the pre-intervention period as compared to 2.5% in the intervention period (p=0.6). The incidence of CLABSI was 3.6/1000 catheter-days (catheter days: 1377) with prevalence of 2.5% in the intervention period, whereas among the historic controls of the previous year it was 4.2/1000 days (catheter days 1432) with a prevalence of 2.2% (p= 0.8). No untoward effect was reported. CONCLUSION: The use of chlorhexidine wipes in ICU was feasible but did not signicantly decrease HAIs.

scholarly journals Association between red blood cell transfusions and clinical outcome in critically ill children

Critical Care ◽  
2013 ◽  
Vol 17 (S2) ◽  
Author(s):  
P Demaret ◽  
M Tucci ◽  
T Ducruet ◽  
H Trottier ◽  
J Lacroix
Keyword(s):  
Clinical Outcome ◽  
Blood Cell ◽  
Critically Ill ◽  
Red Blood Cell ◽  
Critically Ill Children ◽  
Red Blood Cell Transfusions

Red blood cell transfusion in critically ill children: A narrative review*

2011 ◽  
Vol 12 (2) ◽  
pp. 174-183 ◽  
Author(s):  
George K. Istaphanous ◽  
Derek S. Wheeler ◽  
Steven J. Lisco ◽  
Aryeh Shander
Keyword(s):  
Blood Cell ◽  
Critically Ill ◽  
Red Blood Cell ◽  
Narrative Review ◽  
Red Blood Cell Transfusion ◽  
Critically Ill Children

scholarly journals A study on the predictive value of red blood cell distribution width as a biomarker of outcome in paediatric critical illness

2020 ◽  
Vol 7 (12) ◽  
pp. 2347
Author(s):  
Sudha Rudrappa ◽  
Meghana Narasimhegowda ◽  
Girish Gopal
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Blood Cell ◽  
Critically Ill ◽  
Red Blood Cell ◽  
Paediatric Population ◽  
Critically Ill Children ◽  
Cell Distribution ◽  
Distribution Width ◽  
Red Blood Cell Distribution

Background: Red blood cell distribution width (RDW) is a simple, low cost measure, which is routinely reported as a standard component of complete hemogram. Several recent studies have found a positive association between RDW and risk of both morbidity and mortality in several diseases, particularly in critically ill adults.But, data regarding the outcome predictive utility of RDW in critically ill paediatric population is limited. The objective of the study was to determine the association between RDW and mortality and morbidity in paediatric critical illness.Methods: A cross sectional observational study was conducted from February 2019-May 2019 at Cheluvamba Hospital, Mysuru. 97 subjects admitted to Paediatric intensive care unit (PICU) were included in the study. Data regarding subject demographics, hospitalization characteristics, laboratory values and outcomes were collected.Results: A significant positive correlation was found between mortality among critically ill children and RDW measured within 24 hours of PICU admission (p=0.01) and peak RDW during the first 7 days of PICU stay (p=0.01). The relative change in RDW correlated significantly (p=0.01) with the number of intensive care unit (ICU) free days. Our subjects were divided into quartiles based on the admission RDW, subjects in the fourth quartile were found to have the highest mean Paediatric risk of mortality (PRISM III) score, Paediatric index of mortality (PIM 2) score and the least number of ICU free days. Area under the receiver operator curve (AUROC) for incidence of death was 0.706 for admission RDW,0.71 for peak RDW and 0.882 for PIM 2 score.Conclusions: Our data demonstrates that RDW at the time of PICU admission could serve as a cost-effective marker for early identification of critically ill paediatric population who are at risk for adverse outcomes.

Red blood cell transfusion and immune function in critically ill children: a prospective observational study

Transfusion ◽  
2014 ◽  
Vol 55 (4) ◽  
pp. 766-774 ◽  
Author(s):  
Jennifer A. Muszynski ◽  
Elfaridah Frazier ◽  
Ryan Nofziger ◽  
Jyotsna Nateri ◽  
Lisa Hanson-Huber ◽  
...  
Keyword(s):  
Observational Study ◽  
Blood Cell ◽  
Immune Function ◽  
Critically Ill ◽  
Red Blood Cell ◽  
Prospective Observational Study ◽  
Red Blood Cell Transfusion ◽  
Critically Ill Children

scholarly journals Effect of length of storage of red blood cell units on outcome in critically ill children

Critical Care ◽  
2009 ◽  
Vol 13 (Suppl 1) ◽  
pp. P417
Author(s):  
O Karam ◽  
M Tucci ◽  
ST Bateman ◽  
T Ducruet ◽  
P Spinella ◽  
...  
Keyword(s):  
Blood Cell ◽  
Critically Ill ◽  
Red Blood Cell ◽  
Critically Ill Children

scholarly journals Red blood cell transfusion is associated with increased hemolysis and an acute phase response in a subset of critically ill children

2015 ◽  
Vol 90 (10) ◽  
pp. 915-920 ◽  
Author(s):  
Camilla L'Acqua ◽  
Sheila Bandyopadhyay ◽  
Richard O. Francis ◽  
Donald J. McMahon ◽  
Marianne Nellis ◽  
...  
Keyword(s):  
Blood Cell ◽  
Critically Ill ◽  
Acute Phase ◽  
Red Blood Cell ◽  
Acute Phase Response ◽  
Phase Response ◽  
Red Blood Cell Transfusion ◽  
Critically Ill Children
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