scholarly journals Parvovirus B19 infection in sickle cell disease: An analysis from the Centers for Disease Control haemoglobinopathy blood surveillance project

2020 ◽  
Vol 30 (3) ◽  
pp. 226-230
Author(s):  
Suvankar Majumdar ◽  
Christopher J. Bean ◽  
Christine De Staercke ◽  
James Bost ◽  
Robert Nickel ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Disease Control ◽  
Sickle Cell ◽  
Parvovirus B19 ◽  
Cell Disease ◽  
Parvovirus B19 Infection ◽  
Centers For Disease Control

scholarly journals A case of severe multi-system disease in a sickle cell SC patient caused by parvovirus B19 infection

2021 ◽  
Vol 2 (5) ◽  
Author(s):  
Mohamed Almuqamam ◽  
◽  
Swetha Madhavarapu ◽  
Nataly Apollonsky ◽  
◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Parvovirus B19 ◽  
Acute Infection ◽  
Organ Injury ◽  
Acute Chest Syndrome ◽  
Cell Disease ◽  
Splenic Sequestration ◽  
Increased Risk ◽  
Parvovirus B19 Infection

Sickle Cell Disease (SCD) is an inherited hemoglobinopathy, which results in production of abnormal hemoglobin S. HbSC disease is a variant of SCD, which shares a similar clinical complication profile to HbSS disease, but often thought to be a milder condition. In patients with SCD, Hb S in deoxygenated state undergoes polymerization, leading to hemolysis, vaso-occlusive events, and eventually end-organ damage. Among other complications in patients with SCD is increased risk of complications caused by parvovirus B19. We present a case of a 14-year-old female with HbSC disease who presented to the emergency room with complaint of abdominal pain and found to have splenic sequestration. Splenic sequestration progressed rapidly, Hemoglobin (hb) dropped to 4.6 g/dl and acute chest syndrome (ACS) developed. She was treated following the ACS protocol, received 4 units of Packed Red Blood Cells (PRBC) and subsequently underwent a single volume PRBC exchange transfusion. Considering her unusual presentation, with severe ARDS from alveolar hemorrhage requiring mechanical ventilation and multi-organ injury, several autoimmune and infectious conditions with a cytokine storm component including COVID-19 disease, were considered. Results of viral testing revealed parvovirus B19 IgM antibodies signifying an acute infection. She fully recovered with supportive care and was discharged home. Multisystem involvement simulating connective tissue disorders or malignancies with acute parvovirus B19 infection has been reported and is considered extremely rare. To our knowledge, there were no reports of pediatric patients with SC disease presenting with splenic sequestration and ACS in the setting of parvovirus B19 multisystem disease. Keywords: sickle cell disease; acute respiratory distress syndrome; acute chest syndrome; parvovirus B19.

Acute human parvovirus B19 infection in a 6-year old girl with sickle cell disease: a case report

2014 ◽  
Vol 5 ◽  
pp. 1
Author(s):  
Daniele Don� ◽  
Federica Visentin ◽  
Eleonora Borgia ◽  
Stefania Scanferla ◽  
Carlo Giaquinto ◽  
...  
Keyword(s):  
Case Report ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Parvovirus B19 ◽  
Human Parvovirus B19 ◽  
Cell Disease ◽  
Parvovirus B19 Infection

scholarly journals Acute human parvovirus B19 infection and nephrotic syndrome in patients with sickle cell disease

2010 ◽  
Vol 149 (2) ◽  
pp. 289-291 ◽  
Author(s):  
Lynn Quek ◽  
Claire Sharpe ◽  
Neelanjana Dutt ◽  
Sue Height ◽  
Marlene Allman ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Parvovirus B19 ◽  
Human Parvovirus B19 ◽  
Cell Disease ◽  
Parvovirus B19 Infection

scholarly journals Molecular and clinical evaluation of the acute human parvovirus B19 infection: comparison of two cases in children with sickle cell disease and discussion of the literature

2013 ◽  
Vol 17 (1) ◽  
pp. 97-101 ◽  
Author(s):  
Svetoslav Nanev Slavov ◽  
Simone Kashima ◽  
Ana Cristina Silva-Pinto ◽  
Alberto Anastacio Amarilla ◽  
Victor Hugo Aquino ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Clinical Evaluation ◽  
Parvovirus B19 ◽  
Human Parvovirus B19 ◽  
Cell Disease ◽  
Parvovirus B19 Infection

Haematological response to parvovirus B19 infection in homozygous sickle-cell disease

The Lancet ◽  
2001 ◽  
Vol 358 (9295) ◽  
pp. 1779-1780 ◽  
Author(s):  
Beryl E Serjeant ◽  
Ian R Hambleton ◽  
Shane Kerr ◽  
Cormac G Kilty ◽  
Graham R Serjeant
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Parvovirus B19 ◽  
Cell Disease ◽  
Haematological Response ◽  
Parvovirus B19 Infection ◽  
Homozygous Sickle Cell Disease

scholarly journals Original Research: Parvovirus B19 infection in children with sickle cell disease in the hydroxyurea era

2016 ◽  
Vol 241 (7) ◽  
pp. 749-754 ◽  
Author(s):  
Jane S Hankins ◽  
Rhiannon R Penkert ◽  
Paul Lavoie ◽  
Li Tang ◽  
Yilun Sun ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Parvovirus B19 ◽  
Original Research ◽  
Cell Disease ◽  
Parvovirus B19 Infection

scholarly journals Leukoerythroblastosis as an Unusual Presentation of Parvovirus B19 Infection in a Sickle Cell Patient

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Pratik A. Patel ◽  
Elizabeth P. Weinzierl ◽  
Daniel S. Wechsler
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Parvovirus B19 ◽  
Unusual Presentation ◽  
Cell Disease ◽  
Viral Illness ◽  
Life Threatening ◽  
Parvovirus B19 Infection ◽  
Transient Aplastic Crisis ◽  
Fifth Disease

Parvovirus B19 infection in pediatrics most commonly causes fifth disease, a mild viral illness. Hematologic manifestations include severe anemia, especially in patients with chronic hemolytic anemias or who are immunocompromised. Because of the shortened life span of erythrocytes in patients with sickle cell disease, parvovirus infection can cause transient aplastic crisis which can be life-threatening. However, leukocytosis and thrombocytosis are rarely seen. We report leukoerythroblastosis as an unusual presentation of acute parvovirus B19 infection in a previously splenectomized 12-year-old boy with sickle cell disease.

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