Letermovir conversion after valganciclovir treatment in cytomegalovirus high‐risk abdominal solid organ transplant recipients may promote development of cytomegalovirus‐specific cell mediated immunity

2021 ◽  
Author(s):  
Margaret R Jorgenson ◽  
Hanna Kleiboeker ◽  
Neetika Garg ◽  
Sandesh Parajuli ◽  
Didier A Mandelbrot ◽  
...  
Keyword(s):  
High Risk ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Cell Mediated Immunity ◽  
Specific Cell ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Solid Organ Transplant Recipients

Cryptococcosis

2010 ◽  
pp. 1018-1020
Author(s):  
William G. Powderly
Keyword(s):  
Hiv Infection ◽  
Cryptococcus Neoformans ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Cell Mediated Immunity ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Soil Organism ◽  
Organ Transplant Recipients ◽  
Solid Organ Transplant Recipients

Cryptococcus neoformans, which is found worldwide as a soil organism and thought to be transmitted by inhalation, most often causes disease in patients with abnormal cell-mediated immunity, notably patients with HIV infection and solid-organ transplant recipients, but the infection also occurs rarely in apparently immunocompetent people in restricted geographical areas, especially involving ...

Chemoprevention of Skin Carcinomas in High-Risk Transplant Recipients

2018 ◽  
Vol 25 (6) ◽  
pp. 687-697
Author(s):  
Paola Savoia ◽  
Elisa Zavattaro ◽  
Ottavio Cremona
Keyword(s):  
High Risk ◽  
Cell Carcinoma ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Significant Inhibition ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Increased Risk ◽  
Solid Organ Transplant Recipients

Background: Long-term immunosuppressive therapy, as provided to solid organ transplant recipients, inevitably results in a significant inhibition of immune defenses; this leads to frequent skin infections and malignancies, which represent an important cause of morbidity and mortality for transplanted patients. The incidence and risk of skin carcinomas are elevated in solid organ transplant recipients in comparison with the general population, with a 10-fold increased risk for basal cell carcinoma and a 50-100-fold for squamous cell carcinoma. The schedule of immunosuppressive drugs influences the type and timing of skin malignancies, but a crucial role is also played by endogenous and exogenous risk factors. Methods & Results: Here, we will review the state-of-the-art in chemoprevention of epidermal carcinomas in order to provide useful information for clinicians involved in the management of transplant recipients. One-hundred and forteen paper, published on peerreviewed journals, has been included. Conclusion: Chemoprevention would be key in controlling skin carcinogenesis in high-risk patients.

Valganciclovir prophylaxis delays onset of EBV viremia in high-risk pediatric solid organ transplant recipients

2019 ◽  
Vol 87 (5) ◽  
pp. 892-896
Author(s):  
Sawsan Albatati ◽  
Atul Sharma ◽  
Kathryn Haubrich ◽  
Alissa Wright ◽  
Soren Gantt ◽  
...  
Keyword(s):  
High Risk ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Solid Organ Transplant Recipients ◽  
Ebv Viremia
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