Tacrolimus exposure windows responsible for Listeria monocytogenes infection susceptibility

2021 ◽  
Author(s):  
Hilary Miller‐Handley ◽  
John J. Erickson ◽  
Emily J. Gregory ◽  
Nina Salinger Prasanphanich ◽  
Tzu‐Yu Shao ◽  
...  
Keyword(s):  
Listeria Monocytogenes ◽  
Infection Susceptibility ◽  
Listeria Monocytogenes Infection ◽  
Exposure Windows

Listeria monocytogenes infection in Crohn's disease treated with adalimumab

2012 ◽  
Vol 197 (8) ◽  
pp. 466-467 ◽  
Author(s):  
Kaspar J Willson ◽  
Antony Jacob ◽  
Mohit P Shetti ◽  
Rajesh Bhatia ◽  
Kwang Yee ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Listeria Monocytogenes ◽  
Crohn's Disease ◽  
Listeria Monocytogenes Infection

Listeria monocytogenes infection in inflammatory bowel disease patients

2014 ◽  
Vol 26 (11) ◽  
pp. 1247-1252 ◽  
Author(s):  
José Miranda-Bautista ◽  
Camilo Padilla-Suárez ◽  
Emilio Bouza ◽  
Patricia Muñoz ◽  
Luis Menchén ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Listeria Monocytogenes ◽  
Bowel Disease ◽  
Listeria Monocytogenes Infection ◽  
Inflammatory Bowel

scholarly journals Single chain MHC I trimer-based DNA vaccines for protection against Listeria monocytogenes infection

Vaccine ◽  
2012 ◽  
Vol 30 (12) ◽  
pp. 2178-2186 ◽  
Author(s):  
Sojung Kim ◽  
Adam Zuiani ◽  
Javier A. Carrero ◽  
Ted H. Hansen
Keyword(s):  
Listeria Monocytogenes ◽  
Dna Vaccines ◽  
Single Chain ◽  
Mhc I ◽  
Listeria Monocytogenes Infection

scholarly journals CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions

Blood ◽  
2009 ◽  
Vol 113 (19) ◽  
pp. 4711-4719 ◽  
Author(s):  
Kyle J. Eash ◽  
Jacquelyn M. Means ◽  
Douglas W. White ◽  
Daniel C. Link
Keyword(s):  
Bone Marrow ◽  
Listeria Monocytogenes ◽  
Host Tissue ◽  
Microbial Pathogens ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Cxcr4 Signaling ◽  
Listeria Monocytogenes Infection ◽  
A Cell ◽  
Stimulating Factor

Abstract The number of neutrophils in the blood is tightly regulated to ensure adequate protection against microbial pathogens while minimizing damage to host tissue. Neutrophil homeostasis in the blood is achieved through a balance of neutrophil production, release from the bone marrow, and clearance from the circulation. Accumulating evidence suggests that signaling by CXCL12, through its major receptor CXCR4, plays a key role in maintaining neutrophil homeostasis. Herein, we generated mice with a myeloid lineage–restricted deletion of CXCR4 to define the mechanisms by which CXCR4 signals regulate this process. We show that CXCR4 negatively regulates neutrophil release from the bone marrow in a cell-autonomous fashion. However, CXCR4 is dispensable for neutrophil clearance from the circulation. Neutrophil mobilization responses to granulocyte colony-stimulating factor (G-CSF), CXCL2, or Listeria monocytogenes infection are absent or impaired, suggesting that disruption of CXCR4 signaling may be a common step mediating neutrophil release. Collectively, these data suggest that CXCR4 signaling maintains neutrophil homeostasis in the blood under both basal and stress granulopoiesis conditions primarily by regulating neutrophil release from the bone marrow.

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