scholarly journals Clinical Prediction Tool for Extended‐Spectrum Beta‐Lactamase‐Producing Enterobacterales as the Etiology of a Bloodstream Infection in Solid Organ Transplant Recipients

2021 ◽  
Author(s):  
Rebecca Wang ◽  
Jennifer H. Han ◽  
Ebbing Lautenbach ◽  
Pranita D. Tamma ◽  
Kerri A. Thom ◽  
...  
Keyword(s):  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Prediction Tool ◽  
Beta Lactamase ◽  
Transplant Recipients ◽  
Clinical Prediction ◽  
Extended Spectrum Beta Lactamase ◽  
Solid Organ Transplant Recipients ◽  
Clinical Prediction Tool

Cytomegalovirus in Solid Organ Transplant Recipients: Clinical Updates, Challenges and Future Directions

2020 ◽  
Vol 26 (28) ◽  
pp. 3497-3506
Author(s):  
Raymund R. Razonable
Keyword(s):  
Organ Transplantation ◽  
Solid Organ Transplantation ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Cmv Infection ◽  
Future Directions ◽  
Prevention And Treatment ◽  
Solid Organ Transplant Recipients

Cytomegalovirus is the classic opportunistic infection after solid organ transplantation. This review will discuss updates and future directions in the diagnosis, prevention and treatment of CMV infection in solid organ transplant recipients. Antiviral prophylaxis and pre-emptive therapy are the mainstays of CMV prevention, but they should not be mutually exclusive and each strategy should be considered depending on a specific situation. The lack of a widely applicable viral load threshold for diagnosis and preemptive therapy is emphasized as a major factor that should pave the way for an individualized approach to prevention. Valganciclovir and intravenous ganciclovir remain as drugs of choice for CMV management, and strategies for managing drug-resistant CMV infection are enumerated. There is increasing use of CMV-specific cell-mediated immune assays to stratify the risk of CMV infection after solid organ transplantation, and their potential role in optimizing CMV prevention and treatment efforts is discussed.

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