A case ofPneumocystispneumonia, with a granulomatous response and vitamin D‐mediated hypercalcemia, presenting 13 years after renal transplantation

2019 ◽  
Vol 21 (3) ◽  
pp. e13081 ◽  
Author(s):  
Lindsay N. Taylor ◽  
Scott W. Aesif ◽  
Kristine M. Matson
Keyword(s):  
Vitamin D ◽  
Renal Transplantation ◽  
Granulomatous Response

Bone Disease in Renal Transplantation and Pleotropic Effects of Vitamin D Therapy

2010 ◽  
Vol 42 (7) ◽  
pp. 2518-2526 ◽  
Author(s):  
M.M. Sikgenc ◽  
S. Paydas ◽  
M. Balal ◽  
E. Demir ◽  
C. Kurt ◽  
...  
Keyword(s):  
Vitamin D ◽  
Renal Transplantation ◽  
Bone Disease

Pretransplant Serum Vitamin D Levels and Risk of Cancer After Renal Transplantation

2008 ◽  
Vol 85 (12) ◽  
pp. 1755-1759 ◽  
Author(s):  
Didier Ducloux ◽  
Cécile Courivaud ◽  
Jamal Bamoulid ◽  
Amir Kazory ◽  
Gilles Dumoulin ◽  
...  
Keyword(s):  
Vitamin D ◽  
Renal Transplantation ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Risk Of Cancer

scholarly journals P0299EVALUATION OF THE CORRELATION BETWEEN VITAMIN D LEVELS AND THROMBOCYTE MARKERS IN PATIENTS WITH DİALYSİS, CHRONIC RENAL DISEASE AND RENAL TRANSPLANTATION PATIENTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
KÖNÜL AHMEDOVA ◽  
Garip SAHIN ◽  
Cengiz Bal ◽  
Rüya Mutluay
Keyword(s):  
Vitamin D ◽  
Renal Transplantation ◽  
Renal Disease ◽  
Negative Correlation ◽  
Chronic Renal Disease ◽  
Significant Negative Correlation ◽  
Vitamin D Supplementation ◽  
Control Group ◽  
Before And After ◽  
Grade 3

Abstract Background and Aims 25(OH)D3 levels are known to be lower in patients with chronic renal disease (CRD). Vitamin D supplementation has been shown to have beneficial effects on mortality in these patients. In our study, we have evaluated the pleiotropic effect of vitamin D on thrombocyte markers, which is known very little by most. Method The main thrombocyte function markers (MPV, PDW and PCT) were obtained in patients which underwent dialysis, renal transplantation and patients with grade 3-4 CRD before and after vitamin D supplementation. 40 healthy individuals were chosen as control group and 24 patients underwent renal transplantation, 25 patients underwent dialysis for at least 3 months, 32 patients were diagnosed as Grade 3-4 CRD. All of the patients above had 25(OH)D3 levels <20ng/mL (<50nmol/L). Thrombocyte markers were evaluated before and after vitamin D supplementation (which was given 50.000 IU orally once a week for 8 weeks). Results Statistically no significant difference were found between MPV values in- and across- group comparison before and after vitamin D supplementation. After the correlation analyses were reviewed, statistically significant negative correlation was found (r=-0,422 p<0.05) between ΔMPV and ΔVitamin D in renal transplantation group. Also statistically significant positive correlation was found between ΔPDW and ΔVitamin D. In the control group with healty participants, a statistically significant negative correlation was found (r=-0,493 p<0.05) between ΔVitamin D and ΔThrombocyte count. In the dialysis group a statistically significant negative correlation was found (r=-0,422 p<0.05) between ΔVitamin D and ΔMPV. Conclusion A significant correlation was found particularly between Vitamin D and MPV in dialysis and renal transplantation patients. In order to prevent cardiovascular events due to thrombosis caused by Vitamin D deficiency which increases MPV, it has been thought that Vitamin D supplementation and antiaggregant therapy might be beneficial.

P0911TO STUDY CHANGES IN BONE MINERAL DENSITY POST RENAL TRANSPLANTATION

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
PRASHANT MALVIYA ◽  
Soma Sekhar Mudigonda
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Renal Transplantation ◽  
Lumbar Spine ◽  
Renal Transplant ◽  
Bone Mineral ◽  
Hip Joint ◽  
P Value ◽  
Mineral Density ◽  
Dexa Scan

Abstract Background and Aims Chronic kidney disease patients get affected by mineral bone disease in view of changes in various biochemical parameters. After transplantation there are changes in these parameters with additional effect of immunosuppression on bone mineral density. My study was to observe changes in biochemical parameters like calcium, phosphorus, vitamin D, parathyroid hormone, alkaline phosphatase and compare bone mineral density with the help of DEXA scan post renal transplantation after 3 and 6 months. It was a prospective observational comparative study. Aim of my study is to evaluate changes in Bone Mineral Density post renal transplantation Method Study was conducted at Apollo Tertiary care Hospital, Hyderabad which caters to rural as well as urban population in southern parts of India. This study was carried out form June 2017 to Dec 2018. Total 40 patients were included in study and they were followed up for the period of 6 months and underwent sets of investigations to assess their bone mineral density. Biochemical variables consist of calcium, phosphorus, alkaline phosphatase, vitamin D level and iPTH. Biochemical variables were classified into hypo, normal or hyper based on their lab values. iPTH values were considered high if value was nine times the upper limit of normal or low if value was less than two times the upper limit of normal. DEXA scan results were classified into normal, osteopenia and osteoporosis based on their t value. Results Study showed that patients who got admitted for transplant belong to age group of 31 – 50 yrs (39.8 +/- 12.8 yrs) predominantly male patients 30 (75%). In 25% patients (10) we were unable to find out native kidney disease shown as CKD (u). Other common causes were DM, ADPKD, CGN or CIN. Most patients were undergoing dialysis for more than 1 year, 47.5% (19) had significant loss of BMD as compared to patients whose dialysis was <1 year (p value 0.498 and 0.05). Hypocalcemia was predominantly seen in pretransplant period 26 (65%) but as the patient followed up level improved with few developing hypercalcemia 4 (10%) after 6 months. Hyperphosphotemia was seen in 19 (47.5%) patients before transplant while hypophosphatemia in 4 (10%) patients 6 months post transplantation, others had normal phosphorus level. Patients were on calcium and vitamin D supplements developed sufficiency to high level of vitamin D 33 (82.5%) patients 6 months post renal transplant. In iPTH around 12 (30%) of patients were having iPTH >150 pg/dl after 6 months of transplant. Majority presented for transplant detected to have osteoporosis and osteopenia at lumbar spine 31 (77.5%) and hip joint 27 (67.5%) with fracture risk 4 to 8 times of normal population. There was 8% and 10% increase in number of patients having osteoporosis at lumbar spine and hip joint respectively post-transplant. There was loss of 5.5% (mean t score at 0 month -1.98 and at 6 month -2.09) BMD at lumbar spine and 1.7% (mean t score at 0 month -1.83 and at 6 month -1.9) BMD at hip joint. Net loss of BMD was 3.6% over the period of 6 months. This accounts to increased risk of fractures post renal transplant. Biochemical variable in the form of iPTH has shown to have significant association with DEXA scan at lumbar spine (p value 0.01) and hip joint (p value 0.00) before and after transplant (p value of 0.01 and 0.00) though there was fall in iPTH level. Conclusion Pretransplant bone disease remains predominant cause of post-transplant bone disease with significant association with iPTH. Hypophosphatemia, hypercalcemia and high Vitamin D level are common findings in post-transplant period upto 6 months. Early use of DEXA scan along with follow up of biochemical variables can help to prognosticate and decide treatment strategies to reduce fracture risk in renal transplant recipients.

Secondary hyperparathyroidism is associated with vitamin D receptor polymorphism and bone density after renal transplantation

2005 ◽  
Vol 59 (7) ◽  
pp. 402-407 ◽  
Author(s):  
Domenico Rubello ◽  
Sandro Giannini ◽  
Angela D’Angelo ◽  
Martino Nobile ◽  
Gianni Carraio ◽  
...  
Keyword(s):  
Vitamin D ◽  
Renal Transplantation ◽  
Bone Density ◽  
Secondary Hyperparathyroidism ◽  
Vitamin D Receptor ◽  
Vitamin D Receptor Polymorphism ◽  
Receptor Polymorphism

Vitamin D deficiency and parathyroid hormone levels following renal transplantation in children

2010 ◽  
Vol 25 (12) ◽  
pp. 2509-2516 ◽  
Author(s):  
Shamir Tuchman ◽  
Heidi J. Kalkwarf ◽  
Babette S. Zemel ◽  
Justine Shults ◽  
Rachel J. Wetzsteon ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Renal Transplantation ◽  
Vitamin D Deficiency ◽  
Hormone Levels
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