Tuberculin skin test, Interferon gamma release assays or just chest x-ray to study latent tuberculosis before solid organ transplantation?

2018 ◽  
Vol 20 (4) ◽  
pp. e12920
Author(s):  
E. Guirao-Arrabal ◽  
J. Torre-Cisneros
Keyword(s):  
Tuberculin Skin Test ◽  
Organ Transplantation ◽  
Skin Test ◽  
Interferon Gamma ◽  
Solid Organ Transplantation ◽  
Latent Tuberculosis ◽  
Solid Organ ◽  
X Ray ◽  
Interferon Gamma Release Assays ◽  
Chest X Ray

scholarly journals RISK FACTORS OF LATENT TUBERCULOSIS INFECTION IN HEALTHCARE WORKERS AT HOSPITALS IN JEMBER CITY INDONESIA

2020 ◽  
Vol 15 (1) ◽  
pp. 34-40
Author(s):  
Hamidah Retno Wardani ◽  
Ni Made Mertaniasih ◽  
Soedarsono Soedarsono
Keyword(s):  
Risk Factors ◽  
Tuberculin Skin Test ◽  
Skin Test ◽  
Healthcare Workers ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Tuberculosis Infection ◽  
P Value ◽  
X Ray ◽  
Chest X Ray

Background: Healthcare workers in Tuberculosis (TB) and non-TB units in hospitals have a high risk of experiencing Latent Tuberculosis Infection (LTBI), because of exposure to droplets containing Mycobacterium tuberculosis. This study aims to prove LTBI incidence and risk factors to healthcare workers at the hospital in Jember City. Material and Methods: a cross-sectional study, from January to March 2020 in two hospitals in Jember City. Healthcare workers in the TB care and non-TB care unit were examined using Tuberculin skin test (TST) with a cut off ≥ 10 mm for positive LTBI. Chest x-ray and clinical examination to rule out active TB and a standardized questionnaire were also used. Results: 128 healthcare workers completed the questionnaires, clinical, tuberculin skin test (TST), and chest x-ray data. LTBI incidence of positive results 61.7% (n = 79). Contacts TB in the workplace (p value = 0.219; OR = 1.643; CI = 0.742-3.641) and a unit of work (p value = 0.102; OR = 0.760; CI = 0.559-1.031) has no relationship with LTBI. The profession (p value = 0.020; OR = 1.112; CI = 0.896-1.403), the duration of the work (p value = 0.039; OR = 2.984; CI = 1.067-8.342), and BCG immunization (p value =0.000; OR = 0.151; CI = 0.052-0.438) have important relationships with LTBI. Conclusion: TB infection with a high incidence, a risk of transmission to healthcare workers, and a relationship between occupational risk factors and LTBI among healthcare workers in Jember City, Indonesia have been established in this study.

scholarly journals Interferon Gamma Release Assays for Latent Tuberculosis: What Are the Sources of Variability?

2016 ◽  
Vol 54 (4) ◽  
pp. 845-850 ◽  
Author(s):  
Niaz Banaei ◽  
Rajiv L. Gaur ◽  
Madhukar Pai
Keyword(s):  
Tuberculin Skin Test ◽  
Skin Test ◽  
Interferon Gamma ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Low Risk ◽  
Tuberculosis Infection ◽  
Serial Testing ◽  
Conversion Rates ◽  
Interferon Gamma Release Assays

Interferon gamma release assays (IGRAs) are blood-based tests intended for diagnosis of latent tuberculosis infection (LTBI). IGRAs offer logistical advantages and are supposed to offer improved specificity over the tuberculin skin test (TST). However, recent serial testing studies of low-risk individuals have revealed higher false conversion rates with IGRAs than with TST. Reproducibility studies have identified various sources of variability that contribute to nonreproducible results. Sources of variability can be broadly classified as preanalytical, analytical, postanalytical, manufacturing, and immunological. In this minireview, we summarize known sources of variability and their impact on IGRA results. We also provide recommendations on how to minimize sources of IGRA variability.

scholarly journals The Clinical Usefulness of Tuberculin Skin Test versus Interferon-Gamma Release Assays for Diagnosis of Latent Tuberculosis in HIV Patients: A Meta-Analysis

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0161983 ◽  
Author(s):  
Erfan Ayubi ◽  
Amin Doosti-Irani ◽  
Ali Sanjari Moghaddam ◽  
Mohadeseh Sani ◽  
Milad Nazarzadeh ◽  
...  
Keyword(s):  
Tuberculin Skin Test ◽  
Skin Test ◽  
Interferon Gamma ◽  
Meta Analysis ◽  
Latent Tuberculosis ◽  
Clinical Usefulness ◽  
Hiv Patients ◽  
Interferon Gamma Release Assays

scholarly journals Interferon-Gamma Release Assays versus Tuberculin Skin Testing for the Diagnosis of Latent Tuberculosis Infection: An Overview of the Evidence

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
A. Trajman ◽  
R. E. Steffen ◽  
D. Menzies
Keyword(s):  
Tuberculin Skin Test ◽  
Skin Test ◽  
Interferon Gamma ◽  
Clinical Evidence ◽  
Skin Testing ◽  
Latent Tuberculosis ◽  
Preventive Therapy ◽  
Tuberculin Skin Testing ◽  
Interferon Gamma Release Assays ◽  
Definition Of

A profusion of articles have been published on the accuracy and uses of interferon-gamma releasing assays. Here we review the clinical applications, advantages, and limitations of the tuberculin skin test and interferon-gamma release assays and provide an overview of the most recent systematic reviews conducted for different indications for the use of these tests. We conclude that both tests are accurate to detect latent tuberculosis, although interferon-gamma release assays have higher specificity than tuberculin skin testing in BCG-vaccinated populations, particularly if BCG is received after infancy. However, both tests perform poorly to predict risk for progression to active tuberculosis. Interferon-gamma release assays have significant limitations in serial testing because of spontaneous variability and lack of a validated definition of conversion and reversion, making it difficult for clinicians to interpret changes in category (conversions and reversions). So far, the most important clinical evidence, that is, that isoniazid preventive therapy reduces the risk for progression to disease, has been produced only in tuberculin skin test-positive individuals.

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