Clinical significance of quantitative cytomegalovirus detection in bronchoalveolar lavage fluid in lung transplant recipients

2012 ◽  
Vol 15 (1) ◽  
pp. 60-69 ◽  
Author(s):  
E. Schlischewsky ◽  
T. Fuehner ◽  
G. Warnecke ◽  
T. Welte ◽  
A. Haverich ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Clinical Significance ◽  
Lung Transplant ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Transplant Recipients ◽  
Lung Transplant Recipients

Increased Gelatinolytic Activity in Bronchoalveolar Lavage Fluid in Stable Lung Transplant Recipients

1997 ◽  
Vol 156 (6) ◽  
pp. 1978-1986 ◽  
Author(s):  
CONNIE A. TRELLO ◽  
DEBBIE A. WILLIAMS ◽  
CESAR A. KELLER ◽  
COURTNEY CRIM ◽  
ROBERT O. WEBSTER ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Lung Transplant ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Gelatinolytic Activity ◽  
Transplant Recipients ◽  
Lung Transplant Recipients

scholarly journals Early protein expression profile in bronchoalveolar lavage fluid and clinical outcomes in primary graft dysfunction after lung transplantation

2020 ◽  
Vol 58 (2) ◽  
pp. 379-388
Author(s):  
Anna E Frick ◽  
Stijn E Verleden ◽  
Sofie Ordies ◽  
Annelore Sacreas ◽  
Robin Vos ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Lung Transplantation ◽  
Lung Transplant ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Enzyme Linked Immunosorbent Assay ◽  
Transplant Recipients ◽  
Primary Graft Dysfunction ◽  
Graft Dysfunction ◽  
Lung Transplant Recipients

Abstract OBJECTIVES Primary graft dysfunction (PGD) remains a major post-transplant complication and is associated with increased morbidity and mortality. Mechanisms evoking PGD are not completely clear, but inflammation plays a central role. We investigated the association between PGD and inflammatory proteins present in immediate postoperative bronchoalveolar lavage. METHODS All double-lung recipients transplanted at our institution from 2002 to 2018 were included in our study. We retrospectively selected 80 consecutive lung transplant recipients with different PGD grades (n = 20 for each PGD grades 0–1 to 2–3). In bronchoalveolar lavage performed within the first 24 h after donor aortic cross-clamping following lung transplantation, concentrations of 30 cytokines, chemokines and growth factors were assessed by enzyme-linked immunosorbent assay (ELISA) and correlated with donor and recipient demographics and outcomes. For analysis, 2 groups were defined: ‘mild’ PGD (grade 0–1) and ‘severe’ PGD (grades 2–3). RESULTS Significant differences between mild and severe PGD were found in 8 biomarkers [interleukin (IL)-6, IL-10, IL-13, eotaxin, granulocyte colony-stimulating factor, interferon γ, macrophage inflammatory protein 1α, surfactant protein D (SP-D); P < 0.05]. Increased IL-10 and IL-13, but none of the other proteins, were associated with short-term outcome (longer time to extubation; P = 0.005 and P < 0.0001; increased intensive care unit stay; P = 0.012 and P < 0.0001; and hospital stay; P = 0.041 and P = 0.002). There were no significant differences in donor and recipient characteristics between the groups. CONCLUSIONS Expression profiles of key inflammatory mediators in bronchoalveolar lavage fluid differed significantly between lung transplant recipients with severe versus mild PGD and correlated with clinical outcome variables. Further research should focus on the early mechanisms leading to PGD.

CYSTEINYL LEUKOTRIENE LEVELS IN BRONCHOALVEOLAR LAVAGE FLUID OF PEDIATRIC LUNG TRANSPLANT RECIPIENTS

CHEST Journal ◽  
2007 ◽  
Vol 132 (4) ◽  
pp. 606B
Author(s):  
Binal S. Kancherla ◽  
Marc Schecter ◽  
Haibin Zhang ◽  
John Robertson ◽  
Minh Doan ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Lung Transplant ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Transplant Recipients ◽  
Cysteinyl Leukotriene ◽  
Lung Transplant Recipients

scholarly journals Human Cytomegalovirus Load in Plasma and Bronchoalveolar Lavage Fluid: A Longitudinal Study of Lung Transplant Recipients

2004 ◽  
Vol 190 (6) ◽  
pp. 1076-1083 ◽  
Author(s):  
Glen P. Westall ◽  
Alexandra Michaelides ◽  
Trevor J. Williams ◽  
Greg I. Snell ◽  
Thomas C. Kotsimbos
Keyword(s):  
Longitudinal Study ◽  
Bronchoalveolar Lavage ◽  
Human Cytomegalovirus ◽  
Lung Transplant ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Transplant Recipients ◽  
Lung Transplant Recipients
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