Obesity in early onset breast cancer in African American patients

2021 ◽  
Author(s):  
Ida Micaily ◽  
Hannah Hackbart ◽  
Meghan Butryn ◽  
Maysa M. Abu‐Khalaf
Keyword(s):  
Breast Cancer ◽  
African American ◽  
Early Onset ◽  
Early Onset Breast Cancer

BRCA1 E1644X: a deleterious mutation in an African American individual with early onset breast cancer

2008 ◽  
Vol 113 (2) ◽  
pp. 393-395 ◽  
Author(s):  
S. Eric Martin ◽  
Mark Sausen ◽  
Abraham Joseph ◽  
David D. Biggs ◽  
Brewster F. Kingham ◽  
...  
Keyword(s):  
Breast Cancer ◽  
African American ◽  
Early Onset ◽  
Deleterious Mutation ◽  
Early Onset Breast Cancer ◽  
African American Individual

Novel germline BRCA1 mutation (155del4) in an African American with early-onset breast cancer

1999 ◽  
Vol 14 (6) ◽  
pp. 545-545 ◽  
Author(s):  
Joellen Dangel ◽  
Josephine Wagner-Costalas ◽  
Betsy Bove ◽  
Lisa Vanderveer ◽  
Mark Itzen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
African American ◽  
Early Onset ◽  
Brca1 Mutation ◽  
Early Onset Breast Cancer

scholarly journals Differential Patterns of Risk Factors for Early-Onset Breast Cancer by ER Status in African American Women

2016 ◽  
Vol 26 (2) ◽  
pp. 270-277 ◽  
Author(s):  
Kimberly A. Bertrand ◽  
Traci N. Bethea ◽  
Lucile L. Adams-Campbell ◽  
Lynn Rosenberg ◽  
Julie R. Palmer
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
African American ◽  
African American Women ◽  
Early Onset ◽  
Early Onset Breast Cancer ◽  
American Women ◽  
Er Status

scholarly journals High likelihood of actionable pathogenic variant detection in breast cancer genes in women with very early onset breast cancer

2021 ◽  
pp. jmedgenet-2020-107347
Author(s):  
D Gareth Evans ◽  
Elke Maria van Veen ◽  
Helen J Byers ◽  
Sarah J Evans ◽  
George J Burghel ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Onset ◽  
Ductal Carcinoma ◽  
Cancer Genes ◽  
Early Onset Breast Cancer ◽  
Younger Women ◽  
Pathogenic Variants ◽  
Younger Age ◽  
Predisposition Genes

BackgroundWhile the likelihood of identifying constitutional breast cancer-associated BRCA1, BRCA2 and TP53 pathogenic variants (PVs) increases with earlier diagnosis age, little is known about the correlation with age at diagnosis in other predisposition genes. Here, we assessed the contribution of known breast cancer-associated genes to very early onset disease.MethodsSequencing of BRCA1, BRCA2, TP53 and CHEK2 c.1100delC was undertaken in women with breast cancer diagnosed ≤30 years. Those testing negative were screened for PVs in a minimum of eight additional breast cancer-associated genes. Rates of PVs were compared with cases ≤30 years from the Prospective study of Outcomes in Sporadic vs Hereditary breast cancer (POSH) study.ResultsTesting 379 women with breast cancer aged ≤30 years identified 75 PVs (19.7%) in BRCA1, 35 (9.2%) in BRCA2, 22 (5.8%) in TP53 and 2 (0.5%) CHEK2 c.1100delC. Extended screening of 184 PV negative women only identified eight additional actionable PVs. BRCA1/2 PVs were more common in women aged 26–30 years than in younger women (p=0.0083) although the younger age group had rates more similar to those in the POSH cohort. Out of 26 women with ductal carcinoma in situ (DCIS) alone, most were high-grade and 11/26 (42.3%) had a PV (TP53=6, BRCA2=2, BRCA1=2, PALB2=1). This PV yield is similar to the 61 (48.8%) BRCA1/2 PVs identified in 125 women with triple-negative breast cancer. The POSH cohort specifically excluded pure DCIS which may explain lower TP53 PV rates in this group (1.7%).ConclusionThe rates of BRCA1, BRCA2 and TP53 PVs are high in very early onset breast cancer, with limited benefit from testing of additional breast cancer-associated genes.

Breast cancer family history as a risk factor for early onset breast cancer

1988 ◽  
Vol 11 (3) ◽  
pp. 263-267 ◽  
Author(s):  
Henry T. Lynch ◽  
Patrice Watson ◽  
Theresa Conway ◽  
Mary Lee Fitzsimmons ◽  
Jane Lynch
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Family History ◽  
Early Onset ◽  
Early Onset Breast Cancer ◽  
Breast Cancer Family ◽  
Cancer Family ◽  
Cancer Family History ◽  
Breast Cancer Family History

scholarly journals A novel de novo BRCA1 mutation in a Chinese woman with early onset breast cancer

2011 ◽  
Vol 10 (2) ◽  
pp. 233-237 ◽  
Author(s):  
Ava Kwong ◽  
Enders K. O. Ng ◽  
Edmund Y. H. Tang ◽  
Chris L. P. Wong ◽  
Fian B. F. Law ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Onset ◽  
De Novo ◽  
Brca1 Mutation ◽  
Chinese Woman ◽  
Early Onset Breast Cancer

Association of PALB2 sequence variants with the risk of early-onset breast cancer in patients from Turkey

2016 ◽  
Vol 43 (11) ◽  
pp. 1273-1284 ◽  
Author(s):  
G. Cecener ◽  
G. Guney Eskiler ◽  
U. Egeli ◽  
B. Tunca ◽  
A. Alemdar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Onset ◽  
Sequence Variants ◽  
Early Onset Breast Cancer
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