Fatal acute hepatic failure secondary to thrombotic portal venopathy after commencing abemaciclib and fulvestrant treatment for advanced breast carcinoma: a unique autopsy finding

2021 ◽  
Author(s):  
Harry R Haynes ◽  
Vivek Mohan ◽  
Behrang Mozayani ◽  
Patrick Gallagher
Keyword(s):  
Breast Carcinoma ◽  
Hepatic Failure ◽  
Acute Hepatic Failure ◽  
Advanced Breast ◽  
Autopsy Finding

Applying the Principles of Bridging Therapy at Concomitant Acute Hepatic Failure

2016 ◽  
Vol 0 (3.74) ◽  
pp. 112
Author(s):  
I.A. Kuchinskaya ◽  
M.V. Bondar ◽  
D.B. Areshnikov ◽  
S.S. Shapoval ◽  
R.D. Dobush
Keyword(s):  
Hepatic Failure ◽  
Acute Hepatic Failure ◽  
Bridging Therapy

scholarly journals Chronic thyroiditis in patients with advanced breast carcinoma: metabolic and morphologic changes on PET-CT

2009 ◽  
Vol 36 (6) ◽  
pp. 894-902 ◽  
Author(s):  
Ukihide Tateishi ◽  
Cristina Gamez ◽  
Shaheenah Dawood ◽  
Henry W. D. Yeung ◽  
Massimo Cristofanilli ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Advanced Breast ◽  
Chronic Thyroiditis ◽  
Pet Ct ◽  
Morphologic Changes

scholarly journals Treatment of acute hepatic failure and encephalopathy with extracorporeal ex vivo pig-liver perfusion in the critical care unit

Critical Care ◽  
10.1186/cc560 ◽  
1999 ◽  
Vol 3 (Suppl 1) ◽  
pp. P187
Author(s):  
MC DaSilva ◽  
M Gupta ◽  
MJ Holman ◽  
HG Yang ◽  
RL Conter ◽  
...  
Keyword(s):  
Critical Care ◽  
Hepatic Failure ◽  
Critical Care Unit ◽  
Ex Vivo ◽  
Liver Perfusion ◽  
Acute Hepatic Failure ◽  
Pig Liver

62 Clinical results after hormonotherapy in advanced breast carcinoma

1983 ◽  
Vol 19 ◽  
pp. 21
Author(s):  
L. Tedeschi ◽  
G. Beretta ◽  
D. Tabiadon ◽  
G. Luporini
Keyword(s):  
Breast Carcinoma ◽  
Clinical Results ◽  
Advanced Breast

Acute Hepatic Failure in Swine: Hepatectomy Versus Vascular Occlusion

2004 ◽  
Vol 17 (3) ◽  
pp. 163-171 ◽  
Author(s):  
Nils R. Frühauf ◽  
Karl J. Oldhafer ◽  
Stephanie Westermann ◽  
Georgios C. Sotiropoulos ◽  
Gernot M. Kaiser
Keyword(s):  
Hepatic Failure ◽  
Vascular Occlusion ◽  
Acute Hepatic Failure

scholarly journals Anastrozole versus megestrol acetate in the treatment of postmenopausal women with advanced breast carcinoma

Cancer ◽  
1998 ◽  
Vol 83 (6) ◽  
pp. 1142-1152 ◽  
Author(s):  
◽  
Aman U. Buzdar ◽  
Walter Jonat ◽  
Anthony Howell ◽  
Stephen E. Jones ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Postmenopausal Women ◽  
Advanced Breast ◽  
Megestrol Acetate

Acute Fulminant Hepatic Failure in a Woman Treated With Phenytoin and Trimethoprim-Sulfamethoxazole

2000 ◽  
Vol 124 (12) ◽  
pp. 1800-1803 ◽  
Author(s):  
Marius J-M. Ilario ◽  
Jose E. Ruiz ◽  
Constantine A. Axiotis
Keyword(s):  
Liver Injury ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
Acute Hepatic Failure ◽  
Hepatic Necrosis ◽  
Rare Occurrence ◽  
Autopsy Findings ◽  
Massive Hepatic Necrosis

Abstract Massive hepatic necrosis following exposure to phenytoin and trimethoprim-sulfamethoxazole is a rare occurrence and to the best of our knowledge has not been reported previously. Acute hepatic failure following administration of trimethoprim-sulfamethoxazole has rarely been seen, and only 4 cases have been well documented pathologically. We report a case of acute liver failure in a 60-year-old woman following ingestion of phenytoin and trimethoprim-sulfamethoxazole concomitantly over a 9-day period. Autopsy findings revealed acute fulminant hepatic failure. This case demonstrates the effects of chemical-chemical interactions in the potentiation of hepatotoxicity of single agents and specifically illustrates the need for discontinuing trimethoprim-sulfamethoxazole in the presence of early liver injury.

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