Intraoperative radiation therapy or external whole‐breast irradiation, which is more effective in controlling the local recurrence of breast cancer? A Weibull regression model

2021 ◽  
Vol 27 (2) ◽  
pp. 191-193
Author(s):  
Ebrahim Babaee ◽  
Marzieh Nojomi ◽  
Leila Janani ◽  
Arash Tehrani‐Banihashem ◽  
Mahdieh Tutuni ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Local Recurrence ◽  
Regression Model ◽  
Intraoperative Radiation Therapy ◽  
Whole Breast Irradiation ◽  
Breast Irradiation ◽  
Intraoperative Radiation ◽  
Weibull Regression ◽  
Weibull Regression Model

scholarly journals Are Patients Traveling for Intraoperative Radiation Therapy?

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Kelsey E. Larson ◽  
Stephanie A. Valente ◽  
Chirag Shah ◽  
Rahul D. Tendulkar ◽  
Sheen Cherian ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Breast Conservation ◽  
Group Living ◽  
Travel Distance ◽  
Intraoperative Radiation Therapy ◽  
Whole Breast Irradiation ◽  
Breast Irradiation ◽  
Breast Cancer Patients ◽  
Intraoperative Radiation ◽  
Zip Code

Purpose. One benefit of intraoperative radiation therapy (IORT) is that it usually requires a single treatment, thus potentially eliminating distance as a barrier to receipt of whole breast irradiation. The aim of this study was to evaluate the distance traveled by IORT patients at our institution. Methods. Our institutional prospective registry was used to identify IORT patients from 10/2011 to 2/2017. Patient’s home zip code was compared to institution zip code to determine travel distance. Characteristics of local (<50 miles), regional (50–100 miles), and faraway (>100 miles) patients were compared. Results. 150 were patients included with a median travel distance of 27 miles and mean travel distance of 121 miles. Most were local (68.7%), with the second largest group living faraway (20.0%). Subset analysis of local patients demonstrated 20.4% traveled <10 miles, 34.0% traveled 10–20 miles, and 45.6% traveled 20–50 miles. Six patients traveled >1000 miles. The local, regional, and faraway patients did not differ with respect to age, race, tumor characteristics, or whole breast irradiation. Conclusions. Breast cancer patients are traveling for IORT, with 63% traveling >20 miles for care. IORT is an excellent strategy to promote breast conservation in selected patients, particularly those who live remote from a radiation facility.

scholarly journals Changes in peripheral immune cells after intraoperative radiation therapy in low-risk breast cancer

2020 ◽  
Vol 62 (1) ◽  
pp. 110-118
Author(s):  
Isabel Linares-Galiana ◽  
Miguel Angel Berenguer-Frances ◽  
Rut Cañas-Cortés ◽  
Monica Pujol-Canadell ◽  
Silvia Comas-Antón ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Single Dose ◽  
Cancer Patients ◽  
Antitumor Immunity ◽  
Low Risk ◽  
Intraoperative Radiation Therapy ◽  
Breast Cancer Patients ◽  
Intraoperative Radiation ◽  
Risk Breast Cancer

Abstract A detailed understanding of the interactions and the best dose-fractionation scheme of radiation to maximize antitumor immunity have not been fully established. In this study, the effect on the host immune system of a single dose of 20 Gy through intraoperative radiation therapy (IORT) on the surgical bed in low-risk breast cancer patients undergoing conserving breast cancer has been assessed. Peripheral blood samples from 13 patients were collected preoperatively and at 48 h and 3 and 10 weeks after the administration of radiation. We performed a flow cytometry analysis for lymphocyte subpopulations, natural killer cells (NK), regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSCs). We observed that the subpopulation of NK CD56+high CD16+ increased significantly at 3 weeks after IORT (0.30–0.42%, P &lt; 0.001), while no changes were found in immunosuppressive profile, CD4+CD25+Foxp3+Helios+ Treg cells, granulocytic MDSCs (G-MDSCs) and monocytic MDSCs (Mo-MDSCs). A single dose of IORT may be an effective approach to improve antitumor immunity based on the increase in NK cells and the non-stimulation of immunosuppressive cells involved in immune escape. These findings support future combinations of IORT with immunotherapy, if they are confirmed in a large cohort of breast cancer patients.

scholarly journals PD-0479: Intraoperative radiation therapy for breast cancer with INTRABEAMÆ: minimizing cost analysis

2015 ◽  
Vol 115 ◽  
pp. S236-S237
Author(s):  
B. Pinar ◽  
N. Rodriguez-Ibarria ◽  
M.A. Cabezon-Pons ◽  
D. Rey-Baltar ◽  
J.M. Blanco-Suarez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Cost Analysis ◽  
Intraoperative Radiation Therapy ◽  
Intraoperative Radiation
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