Long‐term patient‐rated cosmetic and satisfactory outcomes of early breast cancer treated with conventional versus hypofractionated breast irradiation with simultaneous integrated boost technique

2020 ◽  
Vol 26 (10) ◽  
pp. 1946-1952
Author(s):  
Chawalit Lertbutsayanukul ◽  
Manida Pitak ◽  
Natthagorn Ajchariyasongkram ◽  
Nichakon Rakkiet ◽  
Farinda Seuree ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Breast Cancer ◽  
Simultaneous Integrated Boost ◽  
Breast Irradiation ◽  
Integrated Boost

Hypofractionated Whole Breast Irradiation and Simultaneous Integrated Boost in Large-breasted Patients: Long-term Toxicity and Cosmesis

2020 ◽  
Vol 20 (6) ◽  
pp. 527-533
Author(s):  
Fiorenza De Rose ◽  
Antonella Fogliata ◽  
Davide Franceschini ◽  
Cristina Iftode ◽  
Giuseppe R. D’Agostino ◽  
...  
Keyword(s):  
Simultaneous Integrated Boost ◽  
Whole Breast Irradiation ◽  
Breast Irradiation ◽  
Integrated Boost ◽  
Hypofractionated Whole Breast Irradiation

Hypofractionation with simultaneous integrated boost for early breast cancer

2014 ◽  
Vol 190 (7) ◽  
pp. 646-653 ◽  
Author(s):  
Kathrin Dellas ◽  
Reinhard Vonthein ◽  
Jörg Zimmer ◽  
Stefan Dinges ◽  
Alexander D. Boicev ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Breast Cancer ◽  
Simultaneous Integrated Boost ◽  
Integrated Boost

Accelerated Partial-Breast Irradiation Compared With Whole-Breast Irradiation for Early Breast Cancer: Long-Term Results of the Randomized Phase III APBI-IMRT-Florence Trial

2020 ◽  
Vol 38 (35) ◽  
pp. 4175-4183 ◽  
Author(s):  
Icro Meattini ◽  
Livia Marrazzo ◽  
Calogero Saieva ◽  
Isacco Desideri ◽  
Vieri Scotti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Breast Cancer ◽  
Phase Iii ◽  
Accelerated Partial Breast Irradiation ◽  
Long Term Results ◽  
Partial Breast Irradiation ◽  
Whole Breast Irradiation ◽  
Breast Irradiation ◽  
Once Daily

PURPOSE To report the long-term results of external-beam accelerated partial-breast irradiation (APBI) intensity-modulated radiation therapy (IMRT) Florence phase III trial comparing whole-breast irradiation (WBI) to APBI in early-stage breast cancer. PATIENTS AND METHODS The primary end point was to determine the 5-year difference in ipsilateral breast tumor recurrence (IBTR) between 30 Gy in 5 once-daily fractions (APBI arm) and 50 Gy in 25 fractions with a tumor bed boost (WBI arm) after breast-conserving surgery. RESULTS Five hundred twenty patients, more than 90% of whom had characteristics associated with low recurrence risk, were randomly assigned (WBI, n = 260; APBI, n = 260) between 2005 and 2013. Median follow-up was 10.7 years. The 10-year cumulative incidence of IBTR was 2.5% (n = 6) in the WBI and 3.7% (n = 9) in the APBI arm (hazard ratio [HR], 1.56; 95% CI, 0.55 to 4.37; P = .40). Overall survival at 10 years was 91.9% in both arms (HR, 0.95; 95% CI, 0.50 to 1.79; P = .86). Breast cancer–specific survival at 10 years was 96.7% in the WBI and 97.8% in the APBI arm (HR, 0.65; 95% CI, 0.21 to 1.99; P = .45). The APBI arm showed significantly less acute toxicity ( P = .0001) and late toxicity ( P = .0001) and improved cosmetic outcome as evaluated by both physician ( P = .0001) and patient ( P = .0001). CONCLUSION The 10-year cumulative IBTR incidence in early breast cancer treated with external APBI using IMRT technique in 5 once-daily fractions is low and not different from that after WBI. Acute and late treatment-related toxicity and cosmesis outcomes were significantly in favor of APBI.

scholarly journals Long-term results of hypofractionation with concomitant boost in patients with early breast cancer: A prospective study

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0258186
Author(s):  
Kitwadee Saksornchai ◽  
Thitiporn Jaruthien ◽  
Chonnipa Nantavithya ◽  
Kanjana Shotelersuk ◽  
Prayuth Rojpornpradit
Keyword(s):  
Breast Cancer ◽  
Local Recurrence ◽  
Early Breast Cancer ◽  
Long Term Results ◽  
Whole Breast Irradiation ◽  
Breast Irradiation ◽  
Sequential Boost ◽  
Concomitant Boost ◽  
Hypofractionated Whole Breast Irradiation

Aim To report the long-term local control and survival of patients with early breast cancer who had hypofractionated whole breast irradiation with concomitant boost (Hypo-CB). Methods and materials Between October 2009 and June 2010, 73 patients with early breast cancer (T1-3N0-1M0) who underwent breast conserving surgery were enrolled into the study. Thirty-six of these participants received 50 Gy of conventional irradiation in 25 fractions over 5 weeks to the whole breast with a sequential boost to the tumor bed with 10–16 Gy in 5–8 fractions (Conv-SEQ). The other 37 participants received a hypofractionated dose of 43.2 Gy in 16 fractions with an additional daily concomitant boost (CB) of 0.6 Gy over 3 weeks (Hypo-CB). Results At a median follow-up time of 123 months, ipsilateral local recurrence (ILR) was found in 3 participants, 1 of whom was in the hypofractionated group. All 3 ILR were true local recurrence (TR). There were no significant differences in the 10-year disease free survival (DFS) and 10-year overall survival rates (OS) between the conventional and hypofractionated groups (93.9% vs. 94.4%, p = 0.96 and 91.9% vs. 91.6%, p = 0.792, respectively). Conclusion This study showed that the effectiveness, DFS and OS were comparable between hypofractionated whole breast irradiation with a CB and the conventional irradiation with a sequential boost.

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