Paraneoplastic syndrome as the initial presentation for a mammographically occult breast cancer

2020 ◽  
Vol 26 (3) ◽  
pp. 522-523
Author(s):  
Jason Messinger ◽  
Michelle V. Lee
Keyword(s):  
Breast Cancer ◽  
Paraneoplastic Syndrome ◽  
Initial Presentation ◽  
Occult Breast Cancer

scholarly journals Diffuse Bone Marrow Metastasis as the Initial Presentation of an Occult Breast Cancer

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Frank S. Fan ◽  
Chung-Fan Yang ◽  
Yi-Fen Wang
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Interleukin 1 ◽  
Growth Factor Receptor ◽  
Metastatic Potential ◽  
Initial Presentation ◽  
Unknown Primary ◽  
Bone Marrow Metastasis ◽  
Mucin 1 ◽  
Occult Breast Cancer

Introduction. Breast cancer is one of the malignancies which tend to involve the bone marrow, but initial presentation with diffuse bone marrow metastasis from an occult breast cancer is very rare. Prognosis is generally very poor for marrow metastasis from solid tumors except that breast cancer is a treatable disease even in such a dismal condition. Case. A 64-year-old woman’s headache was found to result from diffuse adenocarcinoma metastasis in the bone marrow from an unknown primary site. Intensive immunohistochemistry study of bone marrow biopsy specimen confirmed the disease nature to be an estrogen receptor-positive/human epidermal growth factor receptor 2-negative breast cancer. Mammography and magnetic resonance imaging of breasts revealed a suspicious primary lesion in the right breast. Treatment with tamoxifen alone achieved a sustained response. Discussion. Mucin 1 (MUC1), also known as cancer antigen 15-3 (CA 15-3), facilitates motility and metastatic potential of breast cancer cells. Interleukin-1β (IL-1β) drives breast cancer cell growth and colonization in bone marrow adipose tissue niche. Receptor activator of nuclear factor kappa-B (RANK) and its ligand (RANKL) activate osteoclasts to make a favorable bone marrow microenvironment for tumor cells. Agents against MUC1, IL-1β, and RANKL might be of therapeutic effect for patients like ours.

Magnetic resonance imaging detection and wire localization of an ‘occult’ breast cancer

1994 ◽  
Vol 32 (3) ◽  
pp. 327-330 ◽  
Author(s):  
Peter L. Davis ◽  
Thomas B. Julian ◽  
Melinda Staiger ◽  
Kathleen B. Harris ◽  
Dennis Borochovitz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Wire Localization ◽  
Resonance Imaging ◽  
Occult Breast Cancer ◽  
Imaging Detection

scholarly journals Clinically Occult Breast Cancer

1980 ◽  
Vol 191 (1) ◽  
pp. 8-12 ◽  
Author(s):  
GORDON F. SCHWARTZ ◽  
ARTHUR S. PATCHEFSKY ◽  
STEPHEN A. FEIG ◽  
GARY S. SHABER ◽  
AMORY B. SCHWARTZ
Keyword(s):  
Breast Cancer ◽  
Occult Breast Cancer

scholarly journals Paraneoplastic polymyositis presenting as a clinically occult breast cancer

2017 ◽  
Vol 99 (2) ◽  
pp. e40-e43 ◽  
Author(s):  
N Merali ◽  
M Yousuff ◽  
V Pronisceva ◽  
A Poddar
Keyword(s):  
Paraneoplastic Syndrome ◽  
Rare Case ◽  
Primary Tumour ◽  
Imaging Studies ◽  
Occult Breast Cancer ◽  
Symptom Stability ◽  
Underlying Malignancy ◽  
Neurological Presentation ◽  
Complete History ◽  
Metaplastic Breast Carcinoma

Paraneoplastic syndrome affects less than 1% of cancer patients. Diagnosis of paraneoplastic syndrome with neurological presentation requires screening for an underlying malignancy, including a complete history, physical examination and imaging studies. Treatment often results in symptom stability, rather than improvement. Paraneoplastic polymyositis can precede or instantaneously occur at diagnosis or treatment of a primary tumour, while neurological symptoms can persist even following cancer treatment. We report a rare case of metaplastic breast carcinoma with an unusual presentation of paraneoplastic polymyositis.

Occult breast cancer: Case report and literature revision

2020 ◽  
Author(s):  
Inês Morais Rodrigues ◽  
Fernando Igreja ◽  
Isabel Riscado ◽  
Rosa Madureira ◽  
Ana Nobre Pinto
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Breast Cancer Case ◽  
Cancer Case ◽  
Occult Breast Cancer
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