Apocrine Metaplasia Found at MR Biopsy: Is There Something to be Learned?

2017 ◽  
Vol 23 (4) ◽  
pp. 429-435 ◽  
Author(s):  
Yiming Gao ◽  
Vandana Dialani ◽  
Carolynn DeBenedectis ◽  
Nicole Johnson ◽  
Elena Brachtel ◽  
...  
Keyword(s):  
Apocrine Metaplasia

Hormonal characterization and classification of breast cyst fluid in gross cystic mastopathy

1994 ◽  
Vol 1 (2) ◽  
pp. 49-55 ◽  
Author(s):  
I Számel ◽  
B Budai ◽  
K Daubner ◽  
J Kralovánszky ◽  
Sz Ottó ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Sex Steroids ◽  
Linear Regression Analysis ◽  
Cyst Fluid ◽  
Type I ◽  
Breast Cyst Fluid ◽  
Breast Cyst ◽  
Apocrine Metaplasia ◽  
Endocrine Parameters

ABSTRACT Gross cystic disease (GCD) of the breast may be associated with a higher risk for the development of breast cancer. High levels of sex steroids, steroid hormone precursors, prolactin and cations have been found in breast cyst fluid (BCF) by several investigators. Accordingly, endocrine parameters and the cationic composition of BCF may be considered as useful characteristics to follow patients bearing macrocysts. In this study we have investigated the concentrations of estradiol (E2), progesterone, testosterone, dehydroepiandrosterone (DHA) and DHA-3-sulfate (DHA-S), prolactin, potassium (K+) and sodium (Na+) in BCF aspirated from 99 women. The mean age of the patients was 49.8 years (range 32-58). The hormone levels were measured by RIA methods; K+ and Na+ were determined by flame photometry. Estradiol, progesterone, testosterone, DHA, DHA-S, prolactin and K+ showed significant accumulation in the BCF compared with their respective serum values. The K+/Na+ ratio proved to be useful in dividing cysts into type I (≥1), type II (<1 but ≥0.1) and type III (<0.1) subgroups. For type I BCF, higher DHA, DHA-S and prolactin concentrations were detected. Linear regression analysis established a highly significant (P<0.001) correlation between the concentrations of E2 and DHA-S (r=0.686), and also between testosterone and DHA-S (r=0.711). These findings indicate that type I BCF might be a marker for 'active' GCD of the breast, and suggest that it may be associated with an increased breast cancer risk, since this group of patients is supposed to have cysts with apocrine metaplasia. It is suggested therefore that when BCF is aspirated, sex steroids, steroid precursors and cations should be routinely measured, and women with type I cysts should be regularly examined.

Cell turnover in apocrine metaplasia and apocrine adenosis of the breast

2010 ◽  
Vol 14 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Ghada Elayat ◽  
Abdel-Ghani A Selim ◽  
Clive A Wells
Keyword(s):  
Cell Turnover ◽  
Apocrine Metaplasia

Significance of Apocrine Metaplasia in Mammary Carcinogenesis.

1990 ◽  
Vol 586 (1 Biochemistry) ◽  
pp. 238-251 ◽  
Author(s):  
J. TÖTH ◽  
I. SZÁMEL ◽  
E. SVASTICS ◽  
E. R. DeSOMBRE
Keyword(s):  
Mammary Carcinogenesis ◽  
Apocrine Metaplasia

scholarly journals Apocrine Carcinoma of Breast: A Case Report with Review of the Literature

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Jyotsna V. Wader ◽  
Akash Jain ◽  
Suresh J. Bhosale ◽  
Pandurang G. Chougale ◽  
Sujata S. Kumbhar
Keyword(s):  
Case Report ◽  
Androgen Receptor ◽  
Breast Carcinoma ◽  
Invasive Breast Carcinoma ◽  
Apocrine Carcinoma ◽  
Review Of The Literature ◽  
Rare Form ◽  
Breast Malignancy ◽  
Apocrine Metaplasia

Apocrine carcinoma is a very rare form of breast malignancy with an incidence of <1% of female invasive breast carcinoma. We report a case of apocrine carcinoma in a 42-year female with marked adenosis showing apocrine metaplasia and discuss the criteria to diagnose apocrine carcinoma with the emerging concept of androgen receptor positivity with its implication on treatment and management of the patient.

Apocrine metaplasia in phyllodes tumours of the breast

1986 ◽  
Vol 10 (11) ◽  
pp. 1211-1211 ◽  
Author(s):  
J.R. Salisbury ◽  
L.N. Singh
Keyword(s):  
Apocrine Metaplasia ◽  
Phyllodes Tumours

Histologic Correlation of Breast Biopsies Presenting as Non-Mass Enhancing Lesions on Magnetic Resonance Imaging: A Contemporary Single Institutional Series

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S155-S155
Author(s):  
J Gruenberg ◽  
A Ravindran ◽  
D Visscher ◽  
E Valencia ◽  
M Wickre
Keyword(s):  
High Risk ◽  
Core Biopsy ◽  
Ductal Carcinoma ◽  
Excisional Biopsy ◽  
Primary Diagnosis ◽  
High Rate ◽  
Radial Scar ◽  
Apocrine Metaplasia ◽  
Ductal Hyperplasia ◽  
Benign Mass

Abstract Introduction/Objective Non-mass enhancement (NME) in breast tissue is an area of enhancement on MRI that appears distinct from background breast parenchyma, but lacks definitive features of a mass. NME is characterized by its internal enhancement pattern and distribution, and can represent benign, high risk, or malignant pathology. Given this considerable overlap, a core biopsy is often necessary for diagnosis and management. We aimed to elucidate the most frequent histologic findings found on breast biopsies for MRI NME. Methods Using our institutional database we identified 70 female patients with high risk status for breast cancer with MRI screen detected NME (BIRADS-4-suspicious for malignancy) that underwent subsequent biopsy procedure during the period of 01/2016-12/2017. Primary pathologic diagnoses were subcategorized as follows: malignant, atypical, benign mass-like lesions, fibrocystic changes (proliferative, nonproliferative), or “other” primary diagnoses. Results The median age of patients was 48 years (range: 22-76 years). Of the 70 patients, 66 underwent MRI-guided core biopsy, 3 underwent ultrasound-guided core biopsy and 1 underwent excisional biopsy. The primary diagnosis was analyzed. Of these 70 cases, 8 (11.4%) were malignant (7 with ductal carcinoma in situ and 1 with invasive ductal carcinoma), 1 (1.4%) had atypical lobular hyperplasia, and the remaining 61 (87.1%) showed benign findings (36 with fibrocystic changes (FCC), 22 benign mass-like lesions, 3 with other non-specific findings). The FCC were subcategorized as proliferative (usual ductal hyperplasia, columnar cell change, incidental radial scar, incidental intraductal papilloma, sclerosing adenosis, focal pseudoangiomatous stromal hyperplasia (PASH)) or nonprolifeative (stromal fibrosis, duct ectasia, apocrine metaplasia). Majority (61.1%) of FCC were both proliferative and nonproliferative, 22.2% proliferative only and 16.7% nonproliferative only. Benign mass-like lesions included PASH (45.4%), fibroadenomatoid nodule (22.7%), fat necrosis (18.2 %) and remaining had the diagnosis of clustered apocrine cysts, papillomatosis, and radial sclerosing lesion. Conclusion Less than a third of cases showed malignant findings and more than two-third of cases showed benign findings with a high rate of detection of proliferative lesions and PASH.

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