Hidradenoma of the Breast: A Source of Diagnostic Confusion

2015 ◽  
Vol 21 (6) ◽  
pp. 681-682 ◽  
Author(s):  
Inês Vasconcelos ◽  
Cornelia Radke ◽  
Óscar Tellechea ◽  
Winfried Schoenegg
Keyword(s):  
Diagnostic Confusion

Diagnostic confusion in paediatric respiratory pathology. Case report

ORL ro ◽  
2016 ◽  
Vol 1 (1) ◽  
pp. 48-50
Author(s):  
Adina A. Zamfir-Chiru-Anton ◽  
D.C. Gheorghe
Keyword(s):  
Case Report ◽  
Foreign Body ◽  
Clinical Picture ◽  
Foreign Body Aspiration ◽  
Effective Therapy ◽  
Partial Loss ◽  
Detailed History ◽  
Therapy Approach ◽  
Diagnostic Confusion ◽  
Respiratory Pathology

The authors present the case of a 4-year-old child admitted to the ENT Department with possible pulmonary foreign body aspiration. A detailed history revealed a clinical picture that seemed to depict an absence episode (with partial loss of conscience and cianosis) occured when eating, less the symptomes of a respiratory foreign body. Diagnosis needed full respiratory endoscopy and neurologic evaluation for correct assesment and effective therapy approach.

Aberrant β-catenin activity in hepatoid adenocarcinoma of the stomach

2020 ◽  
Vol 20 ◽  
Author(s):  
Nan Wang ◽  
Rui Kong ◽  
Wei Han ◽  
Jie Lu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Pearson Correlation ◽  
Clinicopathological Characteristics ◽  
Cancer Tissue ◽  
Hepatoid Adenocarcinoma ◽  
Tumor Initiating Cells ◽  
Significant Difference ◽  
Diagnostic Confusion ◽  
Hematoxylin And Eosin ◽  
Cancer Tissues

Background: Hepatoid adenocarcinoma of the stomach (HAS) has been recognized as a rare primary gastric tumor characterized by hepatocellular carcinoma-like histology. HAS often causes diagnostic confusion with conventional gastric adenocarcinoma (CGA) due to the difficulty to detect hepatoid differentiation solely based on findings from hematoxylin and eosin (H&E) staining. Hence, HAS should be distinguished from solid-type CGA based on their different biological behaviors. β-catenin is highly expressed in hepatocellular carcinoma (HCC), which is involved in the maintenance of tumor initiating cells, drug resistance, tumor progression, and metastasis. Methods and Results: Given the dearth of HAS cases, systematic examination of the expression of β-catenin in HAS remains under-explored. In this study, 14 cases were subjected to immunostaining with with AFP, β-catenin, glypican3, hepar-1 and CerbB-2. In parallel, the clinicopathological characteristics of these patients were collected. We detected statistically significant difference in the expression of β-catenin (P = 0.000), glypican3 (P = 0.019), and hepar-1 (P = 0.007) between HAS cancer tissues and the adjacent non-cancerous tissues. Furthermore, a significant correlation was observed between the expression of β-catenin in HAS cancer tissue and adjacent tissue (Pearson correlation coefficient: 0.686, P = 0.007). Moreover, in cancer tissues, a significant correlation was observed between the expression of β-catenin and survival time (Spearman correlationcoefficient= - 0.482, P = 0.003). However, we found the expression of β-catenin did not correlate with the degree of tumor differentiation and tumor size, age, gender, serum AFP levels, microinvasion, and metastasis (P > 0.05). Conclusion: Our findings establish β-catenin as a useful marker that can distinguish HAS from CGA and may improve the early diagnosis to guide the appropriate and timely treatment of HAS patients.

Posterior Scleritis A Cause of Diagnostic Confusion

1979 ◽  
Vol 97 (8) ◽  
pp. 1482-1486 ◽  
Author(s):  
W. E. Benson ◽  
J. A. Shields ◽  
W. Tasman ◽  
A. S. Crandall
Keyword(s):  
Posterior Scleritis ◽  
Diagnostic Confusion

scholarly journals Biological Markers and Alzheimer Disease: A Canadian Perspective

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Hyman M. Schipper
Keyword(s):  
Alzheimer Disease ◽  
Biological Markers ◽  
Primary Care Physicians ◽  
Biomarker Discovery ◽  
Consensus Conference ◽  
Csf Biomarkers ◽  
Protein Levels ◽  
Canadian Perspective ◽  
Diagnostic Confusion ◽  
With Memory

Decreased -amyloid1-42and increased phospho-tau protein levels in the cerebrospinal fluid (CSF) are currently the most accurate chemical neurodiagnostics of sporadic Alzheimer disease (AD). A report (2007) of the Third Canadian Consensus Conference on the Diagnosis and Treatment of Dementia (2006) recommended that biological markers shouldnotbe currently requisitioned by primary care physicians in the routine investigation of subjects with memory complaints. Consideration for such testing should prompt patient referral to a specialist engaged in dementia evaluations or a Memory Clinic. The specialist should consider having CSF biomarkers (-amyloid1-42and phospho-tau) measured at a reputable facility in restricted cases presenting with atypical features and diagnostic confusion, but not as a routine procedure in all individuals with typical sporadic AD phenotypes. We submit that developments in the field of AD biomarker discovery since publication of the 3rd CCCDTD consensus data do not warrant revision of the 2007 recommendations.

scholarly journals P.097 Subarachnoid hemorrhage associated with a thromboembolic ischemic stroke- an unexpected observation

2018 ◽  
Vol 45 (s2) ◽  
pp. S42-S42
Author(s):  
A Almutlaq ◽  
S Alhusaini ◽  
C Chalk ◽  
R Cote
Keyword(s):  
Ischemic Stroke ◽  
Subarachnoid Hemorrhage ◽  
Ct Scan ◽  
Inferior Frontal Gyrus ◽  
Brain Mri ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Ct Angiogram ◽  
External Capsule ◽  
Diagnostic Confusion

Atherosclerosis is a significant risk factor for ischemic stroke, and is a frequent cause for extra- and intra-cranial vessels stenosis. Here, we present an unusual case of ischemic stroke associated with intra-cranial vessel stenosis and subarachnoid hemorrhage (SAH) secondary to carotid artery atheroma. A 64-year old female known for hypertension and dyslipidemia presented with a three-day history of three transient episodes (< 30 minutes) of dysarthria and right hand weakness. An initial brain CT scan revealed left frontal SAH. She was admitted to our Stroke Unit for observation and management. CT-angiogram revealed 90% ICAs stenosis bilaterally with several short focal stenotic lesions, involving several left MCA branches. Brain MRI revealed acute infarcts in the left insula, external capsule and inferior frontal gyrus. The clinical picture was attributed to a thromboembolic left MCA ischemic stroke. She was managed with maximum medical therapy, and later underwent successful left carotid endarterectomy. The presence of SAH on our patient’s presenting CT scan lead to an initial radiological diagnosis of RCVS. However, subsequent imaging studies indicated that SAH had occurred in association with a thromboembolic ischemic stroke. Despite its rarity, this clinical association is important to recognize to avoid diagnostic confusion and guide appropriate management.

Non-inflammatory myopathies

2013 ◽  
pp. 1033-1040
Author(s):  
Mark Roberts
Keyword(s):  
Structural Integrity ◽  
Genetic Disorders ◽  
Inflammatory Myopathies ◽  
Muscle Enzyme ◽  
Diagnostic Odyssey ◽  
Diagnostic Confusion ◽  
Myopathic Change ◽  
Future Treatments ◽  
And Function ◽  
Inflammatory Changes

Non-inflammatory myopathies (NIM) are a diverse group of genetic disorders, characterized by neuromuscular weakness, fatigue, muscle wasting, and pain, due to inherited defects in proteins critical in the structural integrity and function of muscle fibre or in enzymes involved in energy production in this most metabolic tissue. The shared clinical and laboratory features (including elevated muscle enzyme levels, myopathic change on electromyography, and even inflammatory changes on muscle biopsy) of myositis and NIM frequently cause diagnostic confusion. Failure to distinguish these disorders will result in unnecessary immunosuppression, lack of screening for cardiorespiratory and other associations of NIM, and a missed opportunity for genetic counselling and potential future treatments. A strong index of suspicion is required in all patients presenting with neuromuscular syndromes if a long diagnostic odyssey is to be avoided. A clinically focused multidisciplinary approach, with a working knowledge of subtypes of NIM, is outlined in this chapter.

scholarly journals Testicular vasculitis: a diagnostic conundrum

2020 ◽  
Vol 2020 (4-5) ◽  
Author(s):  
Alice M Malpas ◽  
Richard Y Ball ◽  
Chetan Mukhtyar ◽  
James W MacKay ◽  
Mohammed Omer
Keyword(s):  
Rheumatoid Arthritis ◽  
Patient Care ◽  
Inflammatory Process ◽  
Biologic Therapy ◽  
Autoimmune Disorder ◽  
Diagnostic Bias ◽  
Diagnostic Confusion ◽  
Testicular Lesions ◽  
Single Organ

Abstract Vasculitis is rare in the context of testicular lesions but, when found, can be classified as a single organ vasculitis or part of a multi-organ inflammatory process. In the context of a patient with a pre-existing autoimmune disorder, this finding might cause diagnostic confusion and preferentially bias a physician towards attributing the condition to the known diagnosis or its treatment. This diagnostic bias can interfere with patient care and lead to over caution, resulting in a worse outcome for the patient involved. We describe such a patient with rheumatoid arthritis on biologic therapy.

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