scholarly journals A Comparative Study of Conservative versus Surgical Treatment Protocols for 77 Patients with Idiopathic Granulomatous Mastitis

2015 ◽  
Vol 21 (4) ◽  
pp. 363-369 ◽  
Author(s):  
Hakan Yabanoğlu ◽  
Tamer Çolakoğlu ◽  
Sedat Belli ◽  
Huseyin Ozgur Aytac ◽  
Filiz Aka Bolat ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Comparative Study ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis ◽  
Treatment Protocols

scholarly journals Comparison of Conservative versus Surgical Treatment Protocols in Treating Idiopathic Granulomatous Mastitis: A Meta-Analysis

Breast Care ◽  
2019 ◽  
Vol 15 (4) ◽  
pp. 415-420
Author(s):  
Fei Zhou ◽  
Lu Liu ◽  
Liyuan Liu ◽  
Lixiang Yu ◽  
Fei Wang ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Recurrence Rate ◽  
Meta Analysis ◽  
Clinical Effectiveness ◽  
Breast Disease ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis ◽  
Treatment Protocols ◽  
Significant Difference ◽  
Conservative And Surgical Treatment

Background: Idiopathic granulomatous mastitis (IGM) is a rare, benign breast disease without any definitive therapeutic strategy. It is controversial whether to use conservative or surgical treatment of IGM and high-level evidence-based medicine data are lacking. The purpose of this study was to systemically evaluate the clinical effectiveness of the conservative versus surgical treatment for IGM. Methods: In this meta-analysis, we searched PubMed, EMbase, ScienceDirect, and Web of Science for comparative studies about the conservative versus surgical treatment of IGM. Two researchers independently identified reports and extracted data. We used Stata 11 for data analysis. A meta-analysis was performed to investigate the differences in the recurrence rate of conservative and surgical treatment using a random effects model. Results: A total of 10 studies involving 1,101 patients were included. The results demonstrated that there was no significant difference in the recurrence rate among patients who were treated by nonsurgical therapy and surgical treatment. No publication bias was detected. Conclusion: This meta-analysis demonstrates that both the conservative and surgical treatment approaches have appropriate efficacy in IGM treatment and relapse. Further randomized controlled trials with longer follow-up periods are required to confirm the advantages of each approach.

scholarly journals Combined Treatment Method Comparison Of Medical And Surgical Treatment In Idiopathic Granulomatous Mastitis

2018 ◽  
Vol 5 (4) ◽  
pp. 3737-3742
Author(s):  
Ebubekir Gündeş ◽  
Mehmet Aykut Yildirim ◽  
Tevfik Küçükkartallar ◽  
Faruk Aksoy ◽  
Ahmet Tekin ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Combined Treatment ◽  
Granulomatous Mastitis ◽  
Selective Treatment ◽  
Idiopathic Granulomatous Mastitis ◽  
Therapy Algorithm ◽  
Group I ◽  
Significant Difference ◽  
The Mean

Aim:  Our aim in conducting this study was to ascertain the clinical, pathological, and radiological characteristics of patients diagnosed with idiopathic granulomatous mastitis in our clinic and to contribute to related literature by creating a therapy algorithm for granulomatous mastitis. Method: A total of 62 patients diagnosed with granulomatous mastitis in our clinic were classified into three groups as per the mode of treatment they received. Among these, 20 patients who had only been administered corticosteroids were allocated to Group I, while 18 patients who had received surgical treatment in addition to corticosteroid treatment were allocated to Group II, and 24 patients who had only received surgery were allocated to Group III. Results: All the cases were female patients. The mean age of the patients was 33.67 ± 6.35 (21-48). No statistically significant difference was found among the groups as per the mean age figures, pregnancy, breastfeeding, oral contraceptive administration, smoking and alcohol use, and family history (p>0.05). 49 (77.4%) patients were diagnosed with granulomatous mastitis by thick-needle biopsy, 7 (11.2%) by incisional biopsy, 4 (6.4%) by excisional biopsy, and 3 (4.8%) by fine-needle aspiration biopsy (FNAB) before the onset of treatment. The median value for the follow-up of the patients was 40 (6-81) months and there was no statistically significant difference among follow-up periods (p: 0.51). 15 (24.1%) patients among all the cases had recurrence. There was a statistically significant difference among the groups with regards to recurrence (p: 0.015). Conclusion:  Granulomatous mastitis may simulate breast cancer both clinically and radiologically. Recurrence is observed in patients who only received corticosteroid or surgical treatment. The combination of corticosteroid and surgical treatment significantly reduces the rate of recurrence. Therefore, this combination can be recommended as selective treatment.

scholarly journals Idiopathic granulomatous mastitis - new approach in operative treatment

2022 ◽  
pp. 6-6
Author(s):  
Milan Ranisavljevic ◽  
Nenad Solajic ◽  
Ferenc Vicko
Keyword(s):  
Breast Cancer ◽  
Surgical Treatment ◽  
Breast Reconstruction ◽  
Needle Biopsy ◽  
Locally Advanced ◽  
Clinical Problem ◽  
Granulomatous Mastitis ◽  
Childbearing Age ◽  
Idiopathic Granulomatous Mastitis ◽  
Operative Specimen

Introduction. Idiopathic granulomatous mastitis (GM) is described as a very rare, non-lactating, chronic mastitis that occurs primarily in women of childbearing age. Significant clinical problem related to GM is the diagnostic differentiation from breast cancer. Less advanced forms of GM can be successfully treated with limited surgical excisions and radical treatment is recommended only for the most extensive forms. Case report. First examination of the patient, by the surgeon at Oncology Institute of Vojvodina was in December 2018., when initial suspicion of breast cancer was set up. Core needle biopsy was performed and after histopathological (HP) analysis, confirmation of GM was obtained. The patient was initially offered Prednisone and Methotrexate therapy, which she refused and accepted only surgical treatment. Surgical treatment was performed few weeks after needle biopsy and consisted of performing a nipple spearing mastectomy with excision of the orifices of all fistulous ducts and their primary sutures. The HP findings of the operative specimen confirmed the diagnosis of GM. While there were no signs of dieses relapse, patient was suggested secondary reconstruction of the left breast. Twelve months after the primary operation, secondary breast reconstruction was performed with the interposition of a contoured silicone implant into a muscle pocket in a standard manner. Conclusion. Nipple spearing mastectomy with secondary breast reconstruction is aesthetically satisfactory treatment for patients with locally advanced GM.

scholarly journals Efficacy of surgical treatment in the management of idiopathic granulomatous mastitis: an institutional experience in Sri Lanka

2020 ◽  
Vol 38 (3) ◽  
pp. 21
Author(s):  
Ranali Perera ◽  
Chatura Ratnasooriya ◽  
Naomal Perera ◽  
Nishani Fernando ◽  
Bimalka Senevirathne
Keyword(s):  
Surgical Treatment ◽  
Sri Lanka ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis ◽  
Institutional Experience

scholarly journals AB1053 EFFECTIVENESS OF METHOTREXATE IN IDIOPATHIC GRANULOMATOUS MASTITIS TREATMENT

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1816.1-1817
Author(s):  
D. Yalcin Kehribar ◽  
T. Izci Duran ◽  
A. Kamali Polat ◽  
M. Ozgen
Keyword(s):  
Surgical Treatment ◽  
Nipple Discharge ◽  
Treatment Protocol ◽  
Post Treatment ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis ◽  
Clin Pathol ◽  
Methotrexate Treatment

Background:Idiopathic granulomatous mastitis (IGM) is a rare inflammatory disease of the breast [1], for which there is a lack of consensus on the treatment protocol [2, 3]; it requires long-term follow-up and is associated with a high rate of relapse after surgical treatment. In this study, we report on the largest single-center cohort of idiopathic granulomatous mastitis treated with steroids + methotrexate.Objectives:We present this study believing that our experience with patients with IGM and use of steroid + methotrexate treatment in them will contribute to the literature.Methods:We retrospectively examined the data of 33 patients histopathologically diagnosed with idiopathic granulomatous mastitis who were evaluated by our Rheumatology or General Surgery Clinics between 2013 and 2016.Results:Of the 33 female patients (age: 38.64 ± 6.9 years), 24 were admitted with an initial diagnosis of Idiopathic granulomatous mastitis, whereas 9 were admitted after surgical treatment. The breast symptoms and laboratory values of the patients before and after the steroid and methotrexate treatment are shown in Table 1. Remission was achieved in 87.9% patients with steroid + methotrexate treatment, and there were no relapses during the 24-month follow-up.Table 2.Pre- and post-treatment laboratuary and clinical findings.Pre-treatmentPost-treatmentP valueESR (mm/h)42.45±28.8817.24±11.31<0.001*CRP (mg/L)24.72±35.325.37±6.50.004*Mass Size (mm)36.94±16.4010.79±15.01<0.001*Fistula (n)15/33 (45%)2/33(6%)<0.001**Nipple discharge(n)17/33(52%)1/33(3%)<0.001**ESR: Erythrocyte sedimentation rate; CRP: C-reactive protein; *Paired T Test;**Chi-Square test.Conclusion:Methotrexate has so far been added to IGM treatment in order to decrease steroid dosage or to treat relapses, and it has been reported to be effective in case study and a limited number of studies with few patients [2, 4, 5]. Steroid + methotrexate treatment used by us in patients with IGM, which is a rare disease and for which no consensus exists regarding the treatment protocol, is effective and reliable in providing clinical improvement and long-term remission. Therefore, this treatment appears to be successful owing to long-term remission outcomes and very low relapse rates, without the patients having to undergo a surgical procedure and experience the associated anxiety and complications.References:[1]Kessler, E. and Y. Wolloch, Granulomatous mastitis: a lesion clinically simulating carcinoma. Am J Clin Pathol, 1972. 58(6): p. 642-6.[2]Schmajuk, G. and M.C. Genovese, First report of idiopathic granulomatous mastitis treated with methotrexate monotherapy. J Rheumatol, 2009. 36(7): p. 1559-60.[3]Patel, R.A., et al., Idiopathic granulomatous mastitis: case reports and review of literature. J Gen Intern Med, 2010. 25(3): p. 270-3.[4]Sheybani, F., et al., Treatment for and clinical characteristics of granulomatous mastitis. Obstet Gynecol, 2015. 125(4): p. 801-7.[5]Aghajanzadeh, M., et al., Granulomatous mastitis: Presentations, diagnosis, treatment and outcome in 206 patients from the north of Iran. Breast, 2015. 24(4): p. 456-60.Disclosure of Interests:None declared

scholarly journals Comparison of conservative therapy with steroids and surgical treatment for idiopathic granulomatous mastitis: Our clinical experience

2012 ◽  
Vol 28 (3) ◽  
pp. 134-138
Author(s):  
Alper Parlakgumus ◽  
Sedat Yildirim ◽  
Filiz Bolat ◽  
Aysin Purbager ◽  
Tamer Colakoglu ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Clinical Experience ◽  
Conservative Therapy ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis

scholarly journals Surgical Treatment for Idiopathic Granulomatous Mastitis

2009 ◽  
Vol 77 (3) ◽  
pp. 153 ◽  
Author(s):  
Soon-Young Tae ◽  
Seung-Won Lee ◽  
Sun-uk Han ◽  
Hee-doo Woo ◽  
Doo-Min Son ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis

PREDICTIVE FACTORS IN THE CHOICE OF SURGICAL TREATMENT FOR COLORECTAL CANCER WITH LAPAROSCOPIC OR "OPEN" ACCESS

2017 ◽  
Vol 63 (3) ◽  
pp. 470-474
Author(s):  
Rustem Topuzov ◽  
Georgiy Manikhas ◽  
Eskender Topuzov ◽  
Mikhail Khanevich ◽  
Magomed Abdulaev ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Surgical Treatment ◽  
Postoperative Complications ◽  
Open Access ◽  
Comparative Study ◽  
Retrospective Analysis ◽  
Predictive Factors

There are presented results of surgical treatment of 347 patients with colorectal cancer. Based on the retrospective analysis a comparative study of results of surgical treatment for colorectal cancer using laparoscopic technologies and “open” access was carried out. Predictive factors that correlate with the risk of postoperative complications with laparoscopic and “open” access at the surgical stage of treatment for colorectal cancer were determined.

scholarly journals Serum C-Reactive Protein and Interleukin-6 Levels as Biomarkers for Disease Severity and Clinical Outcomes in Patients with Idiopathic Granulomatous Mastitis

2021 ◽  
Vol 10 (10) ◽  
pp. 2077
Author(s):  
Yi-Min Huang ◽  
Chiao Lo ◽  
Chiao-Feng Cheng ◽  
Cheng-Hsun Lu ◽  
Song-Chou Hsieh ◽  
...  
Keyword(s):  
Disease Severity ◽  
Severe Disease ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Serum Biomarkers ◽  
Healthy Controls ◽  
Granulomatous Mastitis ◽  
C Reactive Protein ◽  
Idiopathic Granulomatous Mastitis ◽  
Reactive Protein

Idiopathic granulomatous mastitis (IGM) is a rare inflammatory breast disease mimicking breast cancer. Limited research has been conducted on the application of serum biomarkers. This study aims to investigate the association of serum biomarkers with disease severity in patients with IGM. From November 2011 to March 2020, medical records of patients with IGM were reviewed. Serum cytokine levels were measured in patients and healthy controls between July 2018 and March 2020. A total of 41 patients with histologically proven IGM were found. Serum interleukin (IL)-6 level was significantly higher in patients with IGM (n = 11) than healthy controls (n = 7). Serum IL-6 and C-reactive protein (CRP) levels were significantly higher in patients with severe disease than mild and moderate disease. Serum IL-6 (Spearman’s ρ = 0.855; p < 0.001) and CRP (Spearman’s ρ = 0.838; p = 0.001) levels were associated with time to resolution. A higher serum CRP level was associated with a longer time to resolution (B = 0.322; p < 0.001) in multiple linear regression analysis. Serum IL-6 and CRP levels can be used as biomarkers for the evaluation of disease severity in IGM. IL-6 may play a crucial role in the immunopathology of IGM.

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