Intraoperative Radiotherapy of Early Breast Cancer Using Low-Kilovoltage X-Rays-Reasons for Omission of Planned Intraoperative Irradiation

2013 ◽  
Vol 19 (3) ◽  
pp. 325-328 ◽  
Author(s):  
Benjamin Tuschy ◽  
Sebastian Berlit ◽  
Christiane Nasterlack ◽  
Karin Tomé ◽  
Elena Blank ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Breast Cancer ◽  
Intraoperative Radiotherapy ◽  
X Rays ◽  
Intraoperative Irradiation ◽  
Low Kilovoltage

scholarly journals Intraoperative Boost Radiotherapy during Targeted Oncoplastic Breast Surgery: Overview and Single Center Experiences

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Wolfram Malter ◽  
Verena Kirn ◽  
Lisa Richters ◽  
Claudius Fridrich ◽  
Birgid Markiefka ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Local Recurrence ◽  
Early Breast Cancer ◽  
Breast Surgery ◽  
Intraoperative Radiotherapy ◽  
Local Therapy ◽  
Breast Conserving Surgery ◽  
Resection Margins ◽  
X Rays ◽  
Oncoplastic Breast Surgery

Breast-conserving surgery followed by whole-breast irradiation is the standard local therapy for early breast cancer. The international discussion of reduced importance of wider tumor-free resection margins than “tumor not touching ink” leads to the development of five principles in targeted oncoplastic breast surgery. IORT improves local recurrence risk and diminishes toxicity since there is less irradiation of healthy tissue. Intraoperative radiotherapy (IORT) can be delivered in two settings: an IORT boost followed by a conventional regimen of external beam radiotherapy or a single IORT dose. The data from TARGIT-A and ELIOT reinforce the conviction that intraoperative radiotherapy during breast-conserving surgery is a reliable alternative to conventional postoperative fractionated irradiation, but only in a carefully selected population at low risk of local recurrence. We describe our experiences with IORT boost (50 kV energy X-rays; 20 Gy) in combination with targeted oncoplastic breast surgery in a routine clinical setting. Our experiences demonstrate the applicability and reliability of combining IORT boost with targeted oncoplastic breast surgery in breast-conserving therapy of early breast cancer.

Intraoperative Radiation Using Low-Kilovoltage X-Rays for Early Breast Cancer: A Single Site Trial

2017 ◽  
Vol 24 (10) ◽  
pp. 3082-3087 ◽  
Author(s):  
Melvin J. Silverstein ◽  
Melinda S. Epstein ◽  
Kevin Lin ◽  
Peter Chen ◽  
Sadia Khan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Breast Cancer ◽  
Single Site ◽  
X Rays ◽  
Intraoperative Radiation ◽  
Low Kilovoltage

Multicenter Phase II Study of Intraoperative Radiotherapy of Early Breast Cancer: Ipsilateral Tumor Recurrence

2019 ◽  
Vol 26 (8) ◽  
pp. 2428-2434 ◽  
Author(s):  
Masataka Sawaki ◽  
Takeshi Miyamoto ◽  
Tomomi Fujisawa ◽  
Yoshiyuki Itoh ◽  
Takeshi Ebara ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Breast Cancer ◽  
Phase Ii ◽  
Tumor Recurrence ◽  
Phase Ii Study ◽  
Intraoperative Radiotherapy ◽  
Multicenter Phase

Intraoperative radiotherapy for early breast cancer and age: clinical characteristics and outcomes

2015 ◽  
Vol 210 (4) ◽  
pp. 624-628 ◽  
Author(s):  
Andrea M. Abbott ◽  
Lesly A. Dossett ◽  
Loretta Loftus ◽  
Weihong Sun ◽  
William Fulp ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Breast Cancer ◽  
Clinical Characteristics ◽  
Intraoperative Radiotherapy

Intraoperative radiotherapy for early breast cancer

The Lancet ◽  
2010 ◽  
Vol 376 (9747) ◽  
pp. 1142 ◽  
Author(s):  
David Cameron ◽  
Ian Kunkler ◽  
Mike Dixon ◽  
Wilma Jack ◽  
Jeremy Thomas ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Breast Cancer ◽  
Intraoperative Radiotherapy

scholarly journals Effect of intraoperative radiotherapy on wound healing in breast cancer patient post breast conserving surgery, KSUMC, Riyadh, Saudi Arabia: Case series and review of literature.

2019 ◽  
Vol 6 (06) ◽  
pp. 4505-4510
Author(s):  
Dr. Maha Alamodi Alghamdi ◽  
Abdulaziz Saleh Altwjri ◽  
Abdullah Alsuhaibani ◽  
Abdulaziz Alsaif
Keyword(s):  
Breast Cancer ◽  
Hormone Receptor ◽  
External Beam Radiotherapy ◽  
Intraoperative Radiotherapy ◽  
Breast Conserving Surgery ◽  
Hormone Receptor Status ◽  
Wound Complications ◽  
External Beam ◽  
X Rays ◽  
Receptor Status

Intraoperative radiotherapy during breast-conserving surgery is being studied as an alternative to 6 weeks of external beam radiotherapy (EBRT) for low-risk women; it can be delivered using electrons (intraoperative electron radiotherapy, IOERT) or 50-kV X-rays. Intraoperative radiation therapy (IORT) may pose a risk for wound complications.  Between March 2018 and June 2018, 5 breast cancer patients, all eligible for breast conserving surgery (BCS), were treated at the King Saud Medical city with IORT using the IOERT. Complete data sets for age, stage (T, N, and M), and histology and hormone receptor status were available in 5 cases. Parameters to identify eligible patients are as follows: ESTRO: >50 years, invasive ductal carcinoma/other favourable histology (IDC), T1-2 (≤3 cm), N0, any hormone receptor status, M0; ASTRO: ≥60 years, IDC, T1, N0, positive estrogen hormone receptor status, M0; TARGIT E “elderly”, risk adapted radiotherapy with IORT followed by external beam radiotherapy in case of risk factors in final histopathology. Consecutive patients operated on with the same surgical technique and given IORT were included. Wound complications were evaluated.

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