VP2 virus‐like particles elicit protective immunity against duckling short beak and dwarfism syndrome in ducks

2021 ◽  
Author(s):  
Shifeng Xiao ◽  
Shao Wang ◽  
Dandan Jiang ◽  
Xiaoxia Cheng ◽  
Xiaoli Zhu ◽  
...  
Keyword(s):  
Protective Immunity ◽  
Virus Like Particles ◽  
Short Beak

scholarly journals Recombinant virus-like particles elicit protective immunity against avian influenza A(H7N9) virus infection in ferrets

Vaccine ◽  
2015 ◽  
Vol 33 (18) ◽  
pp. 2152-2158 ◽  
Author(s):  
Ye V. Liu ◽  
Michael J. Massare ◽  
Melissa B. Pearce ◽  
Xiangjie Sun ◽  
Jessica A. Belser ◽  
...  
Keyword(s):  
Virus Infection ◽  
Avian Influenza ◽  
Recombinant Virus ◽  
Protective Immunity ◽  
Influenza A ◽  
H7n9 Virus ◽  
Virus Like Particles

scholarly journals Influenza Virus-Like Particles Containing M2 Induce Broadly Cross Protective Immunity

PLoS ONE ◽  
2011 ◽  
Vol 6 (1) ◽  
pp. e14538 ◽  
Author(s):  
Jae-Min Song ◽  
Bao-Zhong Wang ◽  
Kyoung-Mi Park ◽  
Nico Van Rooijen ◽  
Fu-Shi Quan ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Protective Immunity ◽  
Virus Like Particles

scholarly journals Rotavirus virus-like particles administered mucosally induce protective immunity.

1997 ◽  
Vol 71 (11) ◽  
pp. 8707-8717 ◽  
Author(s):  
C M O'Neal ◽  
S E Crawford ◽  
M K Estes ◽  
M E Conner
Keyword(s):  
Protective Immunity ◽  
Virus Like Particles

Virus-like particles produced in Saccharomyces cerevisiae elicit protective immunity against Coxsackievirus A16 in mice

2013 ◽  
Vol 97 (24) ◽  
pp. 10445-10452 ◽  
Author(s):  
Hui Zhao ◽  
Hao-Yang Li ◽  
Jian-Feng Han ◽  
Yong-Qiang Deng ◽  
Yue-Xiang Li ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Protective Immunity ◽  
Coxsackievirus A16 ◽  
Virus Like Particles

scholarly journals Epicutaneous immunization using synthetic virus-like particles efficiently boosts protective immunity to respiratory syncytial virus

Vaccine ◽  
2021 ◽  
Author(s):  
Pierre-Louis Hervé ◽  
Véronique Dhelft ◽  
Armando Zuniga ◽  
Arin Ghasparian ◽  
Oliver Rassek ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Protective Immunity ◽  
Virus Like Particles ◽  
Syncytial Virus

scholarly journals A Novel Recombinant Virus-Like Particles Displaying B and T Cell Epitopes of Japanese Encephalitis Virus Offers Protective Immunity in Mice and Guinea Pigs

Vaccines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 980
Author(s):  
Muhammad Naveed Anwar ◽  
Chunying Jiang ◽  
Di Di ◽  
Junjie Zhang ◽  
Shuang Guo ◽  
...  
Keyword(s):  
Japanese Encephalitis Virus ◽  
Japanese Encephalitis ◽  
Guinea Pigs ◽  
Neutralizing Antibodies ◽  
Protective Immunity ◽  
Vaccine Development ◽  
Amino Acid Sequences ◽  
Encephalitis Virus ◽  
Potential Candidate ◽  
Virus Like Particles

Virus-like particles (VLPs) are non-replicative vectors for the delivery of heterologous epitopes and are considered one of the most potent inducers of cellular and humoral immune responses in mice and guinea pigs. In the present study, VLP-JEVe was constructed by the insertion of six Japanese encephalitis virus (JEV) envelope protein epitopes into different surface loop regions of PPV VP2 by the substitution of specific amino acid sequences without altering the assembly of the virus; subsequently, the protective efficacy of this VLP-JEVe was evaluated against JEV challenge in mice and guinea pigs. Mice immunized with the VLP-JEVe antigen developed high titers of neutralizing antibodies and 100% protection against lethal JEV challenge. The neutralizing and hemagglutination inhibition (HI) antibody responses were also induced in guinea pigs vaccinated with VLP-JEVe. In addition, immunization with VLP-JEVe in mice induced effective neutralizing antibodies and protective immunity against PPV (porcine parvovirus) challenge in guinea pigs. These studies suggest that VLP-JEVe produced as described here could be a potential candidate for vaccine development.

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