Genetically modified rabies virus vector‐based bovine ephemeral fever virus vaccine induces protective immune responses against BEFV and RABV in mice

2020 ◽  
Author(s):  
Wenwen Zheng ◽  
Zhongxin Zhao ◽  
Li Tian ◽  
Lele Liu ◽  
Tong Xu ◽  
...  
Keyword(s):  
Immune Responses ◽  
Rabies Virus ◽  
Virus Vaccine ◽  
Genetically Modified ◽  
Fever Virus ◽  
Virus Vector ◽  
Bovine Ephemeral Fever Virus ◽  
Bovine Ephemeral Fever

The protective effectiveness of an inactivated bovine ephemeral fever virus vaccine

2014 ◽  
Vol 173 (1-2) ◽  
pp. 1-8 ◽  
Author(s):  
Orly Aziz-Boaron ◽  
Dan Gleser ◽  
Hagai Yadin ◽  
Boris Gelman ◽  
Maor Kedmi ◽  
...  
Keyword(s):  
Virus Vaccine ◽  
Fever Virus ◽  
Bovine Ephemeral Fever Virus ◽  
Bovine Ephemeral Fever ◽  
Protective Effectiveness

scholarly journals A Senescence-Like Cellular Response Inhibits Bovine Ephemeral Fever Virus Proliferation

Vaccines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 601
Author(s):  
Yu-Jing Zeng ◽  
Min-Kung Hsu ◽  
Chiao-An Tsai ◽  
Chun-Yen Chu ◽  
Hsing-Chieh Wu ◽  
...  
Keyword(s):  
Virus Infection ◽  
Cellular Response ◽  
Cell Clone ◽  
Fever Virus ◽  
Gene Set Enrichment Analysis ◽  
Host Cells ◽  
Scale Production ◽  
Bovine Ephemeral Fever Virus ◽  
Virus Growth ◽  
Bovine Ephemeral Fever

During industrial-scale production of viruses for vaccine manufacturing, anti-viral response of host cells can dampen maximal viral antigen yield. In addition to interferon responses, many other cellular responses, such as the AMPK signaling pathway or senescence-like response may inhibit or slow down virus amplification in the cell culture system. In this study, we first performed a Gene Set Enrichment Analysis of the whole-genome mRNA transcriptome and found a senescence-like cellular response in BHK-21 cells when infected with bovine ephemeral fever virus (BEFV). To demonstrate that this senescence-like state may reduce virus growth, BHK-21 subclones showing varying degrees of a senescence-like state were infected with BEFV. The results showed that the BHK-21 subclones showing high senescence staining could inhibit BEFV replication while low senescence-staining subclones are permissive to virus replication. Using a different approach, a senescence-like state was induced in BHK-21 using a small molecule, camptothecin (CPT), and BEFV susceptibility were examined. The results showed that CPT-treated BHK-21 is more resistant to virus infection. Overall, these results indicate that a senescence-like response may be at play in BHK-21 upon virus infection. Furthermore, cell clone selection and modulating treatments using small molecules may be tools in countering anti-viral responses.

Isolation and genetic characterization of bovine ephemeral fever virus from epidemic-2020 in Turkey

2021 ◽  
Vol 53 (2) ◽  
Author(s):  
Ilke Karayel-Hacioglu ◽  
Selda Duran Yelken ◽  
Yaser Vezir ◽  
Nilay Unal ◽  
Feray Alkan
Keyword(s):  
Genetic Characterization ◽  
Fever Virus ◽  
Bovine Ephemeral Fever Virus ◽  
Bovine Ephemeral Fever

Inhibitors of phosphatidylinositol 3-kinase and mTOR but not Akt enhance replication of bovine ephemeral fever virus

2011 ◽  
Vol 187 (1) ◽  
pp. 119-123 ◽  
Author(s):  
Wen T. Ji ◽  
Ying C. Wang ◽  
Feng L. Lin ◽  
Ming H. Liao ◽  
Wen L. Shih ◽  
...  
Keyword(s):  
Fever Virus ◽  
Phosphatidylinositol 3 Kinase ◽  
Bovine Ephemeral Fever Virus ◽  
Bovine Ephemeral Fever ◽  
Phosphatidylinositol 3

Genetic characterization of bovine ephemeral fever virus in southern China, 2013–2017

Virus Genes ◽  
2020 ◽  
Vol 56 (3) ◽  
pp. 390-395 ◽  
Author(s):  
Jia Kun ◽  
Jia Rongrong ◽  
Wang Xiangbin ◽  
Zhao Yan ◽  
Dou Yiping ◽  
...  
Keyword(s):  
Genetic Characterization ◽  
Southern China ◽  
Fever Virus ◽  
Bovine Ephemeral Fever Virus ◽  
Bovine Ephemeral Fever
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