Properties of virulence emergence of Leishmania infantum isolates from Phlebotomus perniciosus collected during the human leishmaniosis outbreak in Madrid, Spain. Hepatic histopathology and immunological parameters as virulence markers in the mouse model

2020 ◽  
Author(s):  
Alicia Mas ◽  
Abel Martínez‐Rodrigo ◽  
José Antonio Orden ◽  
Ricardo Molina ◽  
Maribel Jiménez ◽  
...  
Keyword(s):  
Mouse Model ◽  
Leishmania Infantum ◽  
Immunological Parameters ◽  
Phlebotomus Perniciosus ◽  
Virulence Markers ◽  
Hepatic Histopathology

scholarly journals Investigations on Mediterranean kala azar IX—Feeding experiment with phlebotomus perniciosus and other species on animals infected with leishmania infantum

1935 ◽  
Vol 116 (801) ◽  
pp. 516-542 ◽  
Keyword(s):  
Small Proportion ◽  
Leishmania Infantum ◽  
Short Form ◽  
Chinese Hamster ◽  
Large Majority ◽  
Feeding Experiment ◽  
Phlebotomus Perniciosus ◽  
Short Forms ◽  
Feeding Experiments ◽  
Kala Azar

In the present paper it is intended to analyse the results of feeding experiments with Phlebotomus perniciosus on animals infected with various strains of Leishmania infantum carried out during 1930, 1931, 1932 and 1933. In a previous paper (1931) the results of feeding experiments carried out on a Chinese hamster from June 18 to October 22, 1930, were discussed. Only 330 sandflies infected by feeding on a Chinese hamster inoculated with Catania strains of L. infantum were included, and the results obtained appeared fairly uniform but for one point. A large majority of sandflies had an infection in which flagellates described as "long forms" predominated and only a small proportion (5%) were infected with "short forms" Proboscis infections ( i. e ., infections in the epipharynx) were observed mainly among the latter. The "short form infections" were observed from September 20 till the end of the sandfly season in 1930.

scholarly journals Immunologic Indicators of Clinical Progression during Canine Leishmania infantum Infection

2009 ◽  
Vol 17 (2) ◽  
pp. 267-273 ◽  
Author(s):  
Paola M. Boggiatto ◽  
Amanda E. Ramer-Tait ◽  
Kyle Metz ◽  
Erin E. Kramer ◽  
Katherine Gibson-Corley ◽  
...  
Keyword(s):  
Leishmania Infantum ◽  
Progressive Disease ◽  
The United States ◽  
Interleukin 10 ◽  
Clinical Disease ◽  
Immunological Parameters ◽  
Peripheral Blood Mononuclear ◽  
Dramatic Rise ◽  
Ifn Γ ◽  
First Time

ABSTRACT In both dogs and humans Leishmania infantum infection is more prevalent than disease, as infection often does not equate with clinical disease. Previous studies additively indicate that advanced clinical visceral leishmaniasis is characterized by increased production of anti-Leishmania antibodies, Leishmania-specific lymphoproliferative unresponsiveness, and decreased production of gamma interferon (IFN-γ) with a concomitant increase of interleukin-10 (IL-10). In order to differentiate infection versus progressive disease for better disease prognostication, we temporally evaluated humoral and cellular immunologic parameters of naturally infected dogs. The work presented here describes for the first time the temporal immune response to natural autochthonous L. infantum infection in foxhounds within the United States. Several key changes in immunological parameters should be considered when differentiating infection versus clinical disease, including a dramatic rise in IgG production, progressive increases in antigen-specific peripheral blood mononuclear cell proliferation, and IFN-γ production. Polysymptomatic disease is precluded by increased IL-10 production and consistent detection of parasite kinetoplast DNA in whole blood. This clinical presentation and the immuno-dysregulation mirror those observed in human patients, indicating that this animal model will be very useful for testing immunomodulatory anti-IL-10 and other therapies.

scholarly journals Vaccination with LiESP/QA-21 (CaniLeish®) reduces the intensity of infection in Phlebotomus perniciosus fed on Leishmania infantum infected dogs—A preliminary xenodiagnosis study

2013 ◽  
Vol 197 (3-4) ◽  
pp. 691-695 ◽  
Author(s):  
Gioia Bongiorno ◽  
Rosa Paparcone ◽  
Valentina Foglia Manzillo ◽  
Gaetano Oliva ◽  
Anne-Marie Cuisinier ◽  
...  
Keyword(s):  
Leishmania Infantum ◽  
Intensity Of Infection ◽  
Phlebotomus Perniciosus

Leishmania infantum nicotinamidase is required for late-stage development in its natural sand fly vector, Phlebotomus perniciosus

2012 ◽  
Vol 42 (4) ◽  
pp. 323-327 ◽  
Author(s):  
Elodie Gazanion ◽  
Veronika Seblova ◽  
Jan Votypka ◽  
Baptiste Vergnes ◽  
Déborah Garcia ◽  
...  
Keyword(s):  
Late Stage ◽  
Leishmania Infantum ◽  
Sand Fly ◽  
Natural Sand ◽  
Phlebotomus Perniciosus ◽  
Stage Development
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