Glycosylation deletion of hemagglutinin head in the H5 subtype avian influenza virus enhances its virulence in mammals by inducing endoplasmic reticulum stress

2020 ◽  
Vol 67 (4) ◽  
pp. 1492-1506
Author(s):  
Yuncong Yin ◽  
Shengqing Yu ◽  
Yingjie Sun ◽  
Tao Qin ◽  
Sujuan Chen ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Influenza Virus ◽  
Endoplasmic Reticulum Stress ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
H5 Subtype

Recombinant duck enteritis virus expressing the HA gene from goose H5 subtype avian influenza virus

Vaccine ◽  
2013 ◽  
Vol 31 (50) ◽  
pp. 5953-5959 ◽  
Author(s):  
Xiaomei Liu ◽  
Shuangshi Wei ◽  
Yan Liu ◽  
Peifen Fu ◽  
Mingchun Gao ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Duck Enteritis Virus ◽  
Ha Gene ◽  
H5 Subtype ◽  
Enteritis Virus

Substitutions in the PB2 methionine 283 residue affect H5 subtype avian influenza virus virulence

2020 ◽  
Vol 67 (6) ◽  
pp. 2554-2563 ◽  
Author(s):  
Sujuan Chen ◽  
Yizhang Xie ◽  
Xiang Su ◽  
Jing Xue ◽  
Xiao Wang ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
H5 Subtype

scholarly journals Global dynamic analysis of H5 subtype avian influenza virus

2021 ◽  
Author(s):  
Ya Chen ◽  
Zhen Jin ◽  
Zhang Juping ◽  
Youming Wang ◽  
Juan Zhang
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Dynamic Model ◽  
Positive Equilibrium ◽  
Global Dynamic ◽  
Live Poultry ◽  
H5 Subtype ◽  
And Control ◽  
Disease Free

In order to study the comprehensive influence of factors such as contact between resident birds and poultry, poultry recruitment, environment and other factors on the transmission and control of H5 subtype avian influenza virus, a dynamic model of resident birds and poultry was developed was established. Firstly, the basic reproduction number R0 was obtained. When R0 > 1, the dynamic model has a unique positive equilibrium and the disease persists. Secondly, the Lyapunov functions was constructed to determine the global stability of the disease-free equilibrium and the endemic equilibrium. The results of numerical simulation show that regular disinfection and sterilization can increase the mortality of virus and effectively prevent the occurrence of epidemic situation. Although closing the live poultry trading market is not the main measure to control the epidemic, but it can control the epidemic to a lower level. Therefore, the regular closure of trading markets and sterilization can prevent and control the spread of the epidemic.

An Impedance Immunosensor for Detection of H5 Subtype Avian Influenza Virus

2013 ◽  
Vol 40 (10) ◽  
pp. 1507-1513
Author(s):  
Xiao-Fei YAN ◽  
Yun-Tao LI ◽  
Rong-Hui WANG ◽  
Jian-Han LIN ◽  
Xin-Hua WEN ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
H5 Subtype ◽  
Impedance Immunosensor

scholarly journals Reverse Transcription Recombinase-aided Amplification Assay for H5 Subtype avian Influenza Virus

2021 ◽  
Author(s):  
Suchun Wang ◽  
Yang Li ◽  
fuyou zhang ◽  
Nan Jiang ◽  
Qingye Zhuang ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Reverse Transcription ◽  
Clinical Sample ◽  
Economic Losses ◽  
Clinical Samples ◽  
Analytical Sensitivity ◽  
Single Temperature ◽  
H5 Subtype

Abstract Background: The H5 subtype avian influenza virus (AIV) has caused huge economic losses to the poultry industry and is a threat to human health. A rapid and simple test is needed to confirm infection in suspected cases during disease outbreaks. Methods: In this study, we developed a reverse transcription recombinase-aided amplification (RT-RAA) assay for the detection of H5 subtype AIV. Assays were performed at a single temperature (39°C), and the results were obtained within 20 min. Results: The assay showed no cross-detection with Newcastle disease virus or infectious bronchitis virus. The analytical sensitivity was 103 RNA copies/μL at a 95% confidence interval according to probit regression analysis, with 100% specificity. Compared with published reverse transcription quantitative real-time polymerase chain reaction assays, the κ value of the RT-RAA assay in 420 avian clinical samples was 0.983 (p < 0.001). The sensitivity for avian clinical sample detection was 97.26% (95% CI, 89.56–99.52%), and the specificity was 100% (95% CI, 98.64–100%). Conclusions: These results indicated that our RT-RAA assay may be a valuable tool for detecting H5 subtype AIV.

scholarly journals Comparison of serological assays for detecting antibodies in ducks exposed to H5 subtype avian influenza virus

2012 ◽  
Vol 8 (1) ◽  
pp. 117 ◽  
Author(s):  
Hendra Wibawa ◽  
Joerg Henning ◽  
Dessie Eri Waluyati ◽  
Tri Bhakti Usman ◽  
Sue Lowther ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
H5 Subtype

scholarly journals Reverse-transcription recombinase-aided amplification assay for H5 subtype avian influenza virus

2020 ◽  
Author(s):  
Suchun Wang ◽  
Yang Li ◽  
Nan Jiang ◽  
Fuyou Zhang ◽  
Qingye Zhuang ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Reverse Transcription ◽  
Economic Losses ◽  
Clinical Samples ◽  
Analytical Sensitivity ◽  
Single Temperature ◽  
Amplification Assay ◽  
H5 Subtype

AbstractThe H5 subtype Avian Influenza Virus has caused huge economic losses to the poultry industry and is a threat to human health. A rapid and simple test is needed to confirm infection in suspected cases during disease outbreaks. In this study, we developed a reverse-transcription recombinase-aided amplification assay for the detection of H5 subtype avian influenza virus. Assays were performed at a single temperature (39°C), and the results were obtained within 20 min. The assay showed no cross-detection with Newcastle disease virus or infectious bronchitis virus. The analytical sensitivity was 103 RNA copies per reaction at a 95% confidence interval according to probit regression analysis, with 100% specificity. Compared with published reverse-transcription quantitative real-time polymerase chain reaction assays, the κ value of the reverse transcription recombinase-aided amplification assay in 365 avian clinical samples was 0.970 (p < 0.001). The sensitivity for avian clinical sample detection was 94.44% (95%CI, 70.63% - 99.71%), and the specificity was 100% (95%CI, 98.64% - 100%). These results indicated that our reverse-transcription recombinase-aided amplification assay may be a valuable tool for detecting H5 subtype avian influenza virus.

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