Prevalence and molecular epidemiology of West Nile and Usutu virus infections in Croatia in the ‘One health’ context, 2018

2019 ◽  
Vol 66 (5) ◽  
pp. 1946-1957 ◽  
Author(s):  
Tatjana Vilibic‐Cavlek ◽  
Vladimir Savic ◽  
Dario Sabadi ◽  
Ljiljana Peric ◽  
Ljubo Barbic ◽  
...  
Keyword(s):  
Molecular Epidemiology ◽  
One Health ◽  
Virus Infections ◽  
West Nile ◽  
Usutu Virus ◽  
The One

West Nile and Usutu virus infections in wild birds admitted to rehabilitation centres in Extremadura, western Spain, 2017–2019

2021 ◽  
Vol 255 ◽  
pp. 109020
Author(s):  
Daniel Bravo-Barriga ◽  
Pilar Aguilera-Sepúlveda ◽  
Fátima Guerrero-Carvajal ◽  
Francisco Llorente ◽  
David Reina ◽  
...  
Keyword(s):  
Wild Birds ◽  
Virus Infections ◽  
West Nile ◽  
Usutu Virus ◽  
Western Spain

scholarly journals Increase in human West Nile and Usutu virus infections, Austria, 2018

2018 ◽  
Vol 23 (43) ◽  
Author(s):  
Stephan W. Aberle ◽  
Jolanta Kolodziejek ◽  
Christof Jungbauer ◽  
Karin Stiasny ◽  
Judith H. Aberle ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Blood Donors ◽  
Blood Donation ◽  
Virus Infections ◽  
West Nile Fever ◽  
West Nile ◽  
Usutu Virus ◽  
Neuroinvasive Disease ◽  
Human West Nile Virus ◽  
Imported Cases

Between 28 June and 17 September 2018, 27 cases of human West Nile virus infections were recorded in Austria; four cases of West Nile neuroinvasive disease, 11 cases of West Nile fever, six infections detected by blood donation screening and six imported cases. In addition, 18 cases of human Usutu virus infections (all blood donors) were recorded. This is the highest number of annual infections recorded in Austria since the introduction of both viruses.

scholarly journals Importance of Multidisciplinary and Regional Collaboration in Integrated West Nile Virus Surveillance - the „One Health” Concept

2020 ◽  
Vol 39 (2) ◽  
pp. 40-47 ◽  
Author(s):  
Tatjana Vilibić-Čavlek ◽  
Dejan Vidanović ◽  
Ljubo Barbić ◽  
Pavle Jeličić ◽  
Sava Lazić ◽  
...  
Keyword(s):  
West Nile Virus ◽  
One Health ◽  
West Nile ◽  
Virus Surveillance ◽  
Regional Collaboration ◽  
Health Concept ◽  
The One

West Nile virus (WNV) danas je jedan od najrasprostranjenijih arbovirusa. U posljednja se dva desetljeća WNV infekcije kontinuirano pojavljuju na području Europe u obliku manjih ili većih epidemija i epizootija. U ovom preglednom radu prikazujemo epidemiološke značajke WNV infekcija koje su dokazane na području Hrvatske i Srbije u kontekstu “Jednog zdravlja”. Prikazani rezultati potvrđuju značaj multidisciplinarne i regionalne suradnje u dijagnostici i praćenju ove (re-)emergentne virusne zoonoze.

scholarly journals Emerging Trends in the Epidemiology of West Nile and Usutu Virus Infections in Southern Europe

2019 ◽  
Vol 6 ◽  
Author(s):  
Tatjana Vilibic-Cavlek ◽  
Vladimir Savic ◽  
Tamas Petrovic ◽  
Ivan Toplak ◽  
Ljubo Barbic ◽  
...  
Keyword(s):  
Southern Europe ◽  
Virus Infections ◽  
West Nile ◽  
Usutu Virus ◽  
Emerging Trends

scholarly journals Strengthening the One Health Agenda: The Role of Molecular Epidemiology in Aspergillus Threat Management

Genes ◽  
2018 ◽  
Vol 9 (7) ◽  
pp. 359 ◽  
Author(s):  
Eta Ashu ◽  
Jianping Xu
Keyword(s):  
Public Health ◽  
Molecular Epidemiology ◽  
One Health ◽  
Species Level ◽  
Aspergillus Species ◽  
Diagnostic Tools ◽  
Health Initiative ◽  
Threat Management ◽  
The One

The United Nations’ One Health initiative advocates the collaboration of multiple sectors within the global and local health authorities toward the goal of better public health management outcomes. The emerging global health threat posed by Aspergillus species is an example of a management challenge that would benefit from the One Health approach. In this paper, we explore the potential role of molecular epidemiology in Aspergillus threat management and strengthening of the One Health initiative. Effective management of Aspergillus at a public health level requires the development of rapid and accurate diagnostic tools to not only identify the infecting pathogen to species level, but also to the level of individual genotype, including drug susceptibility patterns. While a variety of molecular methods have been developed for Aspergillus diagnosis, their use at below-species level in clinical settings has been very limited, especially in resource-poor countries and regions. Here we provide a framework for Aspergillus threat management and describe how molecular epidemiology and experimental evolution methods could be used for predicting resistance through drug exposure. Our analyses highlight the need for standardization of loci and methods used for molecular diagnostics, and surveillance across Aspergillus species and geographic regions. Such standardization will enable comparisons at national and global levels and through the One Health approach, strengthen Aspergillus threat management efforts.

scholarly journals First neuroinvasive human case of West Nile Disease in Southern Italy: Results of the ‘One Health’ approach

2021 ◽  
Author(s):  
Giusi Macaluso ◽  
Francesca Gucciardi ◽  
Annalisa Guercio ◽  
Valeria Blanda ◽  
Francesco La Russa ◽  
...  
Keyword(s):  
One Health ◽  
Southern Italy ◽  
Human Case ◽  
West Nile ◽  
The One

Serologic evidence of West Nile virus and Usutu virus infections in Eurasian coots in the Netherlands

2017 ◽  
Vol 65 (1) ◽  
pp. 96-102 ◽  
Author(s):  
S. M. Lim ◽  
M. Geervliet ◽  
J. H. Verhagen ◽  
G. J. D. M. Müskens ◽  
F. A. Majoor ◽  
...  
Keyword(s):  
West Nile Virus ◽  
The Netherlands ◽  
Virus Infections ◽  
West Nile ◽  
Usutu Virus ◽  
Serologic Evidence

scholarly journals First Autochthonous West Nile Lineage 2 and Usutu Virus Infections in Humans, July to October 2018, Czech Republic

Pathogens ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 651
Author(s):  
Hana Zelená ◽  
Jana Kleinerová ◽  
Silvie Šikutová ◽  
Petra Straková ◽  
Hana Kocourková ◽  
...  
Keyword(s):  
Czech Republic ◽  
West Nile Virus ◽  
Fatal Case ◽  
First Record ◽  
Virus Infections ◽  
West Nile ◽  
Laboratory Findings ◽  
The Czech Republic ◽  
Usutu Virus ◽  
Lineage 2

We present epidemiological, clinical and laboratory findings of five Czech patients diagnosed with autochthonous mosquito-borne disease—four patients with confirmed West Nile virus (WNV) and one patient with Usutu virus (USUV) infections, from July to October 2018, including one fatal case due to WNV. This is the first documented human outbreak caused by WNV lineage 2 in the Czech Republic and the first record of a neuroinvasive human disease caused by USUV, which illustrates the simultaneous circulation of WNV and USUV in the country.

scholarly journals Pathology of fatal lineage 1 and 2 West Nile virus infections in horses in South Africa

2014 ◽  
Vol 85 (1) ◽  
Author(s):  
June H. Williams ◽  
Stephanie Van Niekerk ◽  
Stacey Human ◽  
Erna Van Wilpe ◽  
Marietjie Venter
Keyword(s):  
West Nile Virus ◽  
South African ◽  
Viral Entry ◽  
Plasma Cells ◽  
Ventral Horn ◽  
Virus Infections ◽  
Rt Pcr ◽  
West Nile ◽  
Lineage 2 ◽  
The One

Since 2007, West Nile virus (WNV) has been reported in South African horses, causing severe neurological signs. All cases were of lineage 2, except for one case that clustered with lineage 1 viruses. In the present study, gross and microscopic lesions of six South African lineage 2-infected horses and the one lineage 1 case are described. Diagnoses were confirmed by real-time reverse-transcriptase polymerase chain reaction (RT-PCR) of central nervous system (CNS) tissue and one by RT-PCR of a brain virus isolate. The CNS of all cases was negative by RT-PCR or immunohistochemistry (IHC) for African horse sickness (AHS), equine encephalosis virus, equine herpes viruses 1 and 4, other zoonotic flaviviruses, alphaviruses, and shunivirus, and either by immunofluorescence or IHC for rabies. Gross visceral lesions were nonspecific but often mimicked those of AHS. The CNS histopathology of WNV lineage 2 cases resembled the nonsuppurative polioencephalomyelitis reported in the Northern Hemisphere lineage 1 and recent Hungarian lineage 2 cases. Occasional meningitis, focal spinal ventral horn poliomalacia, dorsal and lateral horn poliomyelitis, leucomyelitis, asymmetrical ventral motor spinal neuritis and frequent olfactory region involvement were also seen. Lineage 2 cases displayed marked variations in CNS lesion severity, type and distribution, and suggested various viral entry routes into the CNS, based on findings in experimental mice and hamsters. Lineage 1 lesions were comparable to the milder lineage 2 cases. West Nile virus IHC on CNS sections with marked lesions from all cases elicited only two antigen-positive cells in the olfactory cortex of one case. The presence in the CNS of T-lymphocytes, B-lymphocytes, plasma cells and macrophage-monocytes was confirmed by cluster of differentiation (CD) 3, CD20, multiple myeloma oncogene 1 (MUM1) and macrophage (MAC) 387 IHC.

scholarly journals Evidence for West Nile Virus and Usutu Virus Infections in Wild and Resident Birds in Germany, 2017 and 2018

Viruses ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 674 ◽  
Author(s):  
Friederike Michel ◽  
Michael Sieg ◽  
Dominik Fischer ◽  
Markus Keller ◽  
Martin Eiden ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Migratory Birds ◽  
Bird Species ◽  
Neutralizing Antibody ◽  
Positive Sample ◽  
Virus Infections ◽  
Northern Germany ◽  
West Nile ◽  
Usutu Virus ◽  
Eastern Germany

Wild birds play an important role as reservoir hosts and vectors for zoonotic arboviruses and foster their spread. Usutu virus (USUV) has been circulating endemically in Germany since 2011, while West Nile virus (WNV) was first diagnosed in several bird species and horses in 2018. In 2017 and 2018, we screened 1709 live wild and zoo birds with real-time polymerase chain reaction and serological assays. Moreover, organ samples from bird carcasses submitted in 2017 were investigated. Overall, 57 blood samples of the live birds (2017 and 2018), and 100 organ samples of dead birds (2017) were positive for USUV-RNA, while no WNV-RNA-positive sample was found. Phylogenetic analysis revealed the first detection of USUV lineage Europe 2 in Germany and the spread of USUV lineages Europe 3 and Africa 3 towards Northern Germany. USUV antibody prevalence rates were high in Eastern Germany in both years. On the contrary, in Northern Germany, high seroprevalence rates were first detected in 2018, with the first emergence of USUV in this region. Interestingly, high WNV-specific neutralizing antibody titers were observed in resident and short-distance migratory birds in Eastern Germany in 2018, indicating the first signs of a local WNV circulation.

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