scholarly journals Circulation and genetic diversity of Feline coronavirus type I andIIfrom clinically healthy andFIP‐suspected cats in China

2018 ◽  
Vol 66 (2) ◽  
pp. 763-775 ◽  
Author(s):  
Chunqiu Li ◽  
Qiujin Liu ◽  
Fanzhi Kong ◽  
Donghua Guo ◽  
Junjun Zhai ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Type I ◽  
Feline Coronavirus

scholarly journals Genetic diversity and correlation with feline infectious peritonitis of feline coronavirus type I and II: A 5-year study in Taiwan

2009 ◽  
Vol 136 (3-4) ◽  
pp. 233-239 ◽  
Author(s):  
Chao-Nan Lin ◽  
Bi-Ling Su ◽  
Ching-Ho Wang ◽  
Ming-Wei Hsieh ◽  
Ti-Jen Chueh ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Type I ◽  
Feline Infectious Peritonitis ◽  
Feline Coronavirus

scholarly journals Virulence, Molecular Diversity, and Mating Type of Curvularia lunata in China

Plant Disease ◽  
2019 ◽  
Vol 103 (7) ◽  
pp. 1728-1737 ◽  
Author(s):  
Dan Zhang ◽  
Fen Wang ◽  
Jiamei Zhao ◽  
Jiaying Sun ◽  
Dandan Fu ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Mating Type ◽  
Molecular Diversity ◽  
Fragment Length Polymorphism ◽  
Selective Pressure ◽  
Phenotypic Expression ◽  
Curvularia Lunata ◽  
Type I ◽  
Resistant Varieties ◽  
Differential Hosts

Curvularia leaf spot (CuLS), caused by Curvularia lunata, is a devasting foliar disease in the maize-growing regions of China. Resistant varieties were widely planted in these regions in response to CuLS. However, over time, C. lunata has gradually adapted to the selective pressure and, in recent years, the incidence of CuLS has increased. To assess the correlation between virulence and genetic diversity, a total of 111 isolates was collected from 15 maize-growing regions located in nine provinces in China. These isolates were evaluated for virulence on maize using nine differential hosts: Shen135, CN165, Mo17, Luyuan92, 78599, Ye478, B73, E28, and Huangzaosi. To evaluate the genetic diversity, 657 polymorphic amplified fragment length polymorphism markers were generated. Results showed that the isolates could be grouped into three pathotypes according to the phenotypic expression of the differential inbred lines. Isolates were clustered into two genetic diversity groups and further divided into subgroups. However, the correlation between virulence and genetic diversity grouping was low. Also, there was a low correlation observed between pathotype and geographic distribution. The ratio of mating type I to mating type II for all isolates was close to 3:4.

scholarly journals Antiviral Effects of Hydroxychloroquine and Type I Interferon on In Vitro Fatal Feline Coronavirus Infection

Viruses ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 576 ◽  
Author(s):  
Tomomi Takano ◽  
Kumi Satoh ◽  
Tomoyoshi Doki ◽  
Taishi Tanabe ◽  
Tsutomu Hohdatsu
Keyword(s):  
Viral Infections ◽  
Viral Disease ◽  
High Morbidity ◽  
Type I ◽  
Feline Infectious Peritonitis ◽  
Antiviral Effects ◽  
Immune Mediated ◽  
Coronavirus Infection ◽  
Feline Coronavirus

Feline infectious peritonitis (FIP) is a viral disease with a high morbidity and mortality by the FIP virus (FIPV, virulent feline coronavirus). Several antiviral drugs for FIP have been identified, but many of these are expensive and not available in veterinary medicine. Hydroxychloroquine (HCQ) is a drug approved by several countries to treat malaria and immune-mediated diseases in humans, and its antiviral effects on other viral infections (e.g., SARS-CoV-2, dengue virus) have been confirmed. We investigated whether HCQ in association with interferon-ω (IFN-ω) is effective for FIPV in vitro. A total of 100 μM of HCQ significantly inhibited the replication of types I and II FIPV. Interestingly, the combination of 100 μM of HCQ and 104 U/mL of recombinant feline IFN-ω (rfIFN-ω, veterinary registered drug) increased its antiviral activity against type I FIPV infection. Our study suggested that HCQ and rfIFN-ω are applicable for treatment of FIP. Further clinical studies are needed to verify the combination of HCQ and rIFN-ω will be effective and safe treatment for cats with FIP.

scholarly journals Origin and transmission of Feline coronavirus type I in domestic cats from Northern Italy: a phylogeographic approach

2020 ◽  
Vol 244 ◽  
pp. 108667 ◽  
Author(s):  
Stefania Lauzi ◽  
Angelica Stranieri ◽  
Alessia Giordano ◽  
Camilla Luzzago ◽  
Gianguglielmo Zehender ◽  
...  
Keyword(s):  
Northern Italy ◽  
Type I ◽  
Domestic Cats ◽  
Feline Coronavirus

scholarly journals Importance of the Host Phenotype on the Preservation of the Genetic Diversity in Codling Moth Granulovirus

Viruses ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 621 ◽  
Author(s):  
Graillot ◽  
Blachere-López ◽  
Besse ◽  
Siegwart ◽  
López-Ferber
Keyword(s):  
Genetic Diversity ◽  
Cydia Pomonella ◽  
Codling Moth ◽  
Type I ◽  
Host Genotype ◽  
Host Colony ◽  
Type I Resistance ◽  
Cydia Pomonella Granulovirus ◽  
Marker Virus ◽  
Mexican Isolate

To test the importance of the host genotype in maintaining virus genetic diversity, five experimental populations were constructed by mixing two Cydia pomonella granulovirus isolates, the Mexican isolate CpGV-M and the CpGV-R5, in ratios of 99% M + 1% R, 95% M + 5% R, 90% M + 10% R, 50% M + 50% R, and 10% M + 90% R. CpGV-M and CpGV-R5 differ in their ability to replicate in codling moth larvae carrying the type I resistance. This ability is associated with a genetic marker located in the virus pe38 gene. Six successive cycles of replication were carried out with each virus population on a fully-permissive codling moth colony (CpNPP), as well as on a host colony (RGV) that carries the type I resistance, and thus blocks CpGV-M replication. The infectivity of offspring viruses was tested on both hosts. Replication on the CpNPP leads to virus lineages preserving the pe38 markers characteristic of both isolates, while replication on the RGV colony drastically reduces the frequency of the CpGV-M pe38 marker. Virus progeny obtained after replication on CpNPP show consistently higher pathogenicity than that of progeny viruses obtained by replication on RGV, independently of the host used for testing.

scholarly journals Global Biodiversity Patterns of the Photobionts Associated with the Genus Cladonia (Lecanorales, Ascomycota)

2020 ◽  
Author(s):  
Raquel Pino-Bodas ◽  
Soili Stenroos
Keyword(s):  
Genetic Diversity ◽  
Genetic Variation ◽  
Sexual Reproduction ◽  
Geographical Distribution ◽  
Type I ◽  
Generalist Species ◽  
Climatic Regions ◽  
The World ◽  
Global Biodiversity ◽  
High Diversity

Abstract The diversity of lichen photobionts is not fully known. We studied here the diversity of the photobionts associated with Cladonia, a sub-cosmopolitan genus ecologically important, whose photobionts belong to the green algae genus Asterochloris. The genetic diversity of Asterochloris was screened by using the ITS rDNA and actin type I regions in 223 specimens and 135 species of Cladonia collected all over the world. These data, added to those available in GenBank, were compiled in a dataset of altogether 545 Asterochloris sequences occurring in 172 species of Cladonia. A high diversity of Asterochloris associated with Cladonia was found. The commonest photobiont lineages associated with this genus are A. glomerata, A. italiana, and A. mediterranea. Analyses of partitioned variation were carried out in order to elucidate the relative influence on the photobiont genetic variation of the following factors: mycobiont identity, geographic distribution, climate, and mycobiont phylogeny. The mycobiont identity and climate were found to be the main drivers for the genetic variation of Asterochloris. The geographical distribution of the different Asterochloris lineages was described. Some lineages showed a clear dominance in one or several climatic regions. In addition, the specificity and the selectivity were studied for 18 species of Cladonia. Potentially specialist and generalist species of Cladonia were identified. A correlation was found between the sexual reproduction frequency of the host and the frequency of certain Asterochloris OTUs. Some Asterochloris lineages co-occur with higher frequency than randomly expected in the Cladonia species.

scholarly journals Isolation and molecular characterization of type I and type II feline coronavirus in Malaysia

2012 ◽  
Vol 9 (1) ◽  
pp. 278 ◽  
Author(s):  
Amer Alazawy ◽  
Siti Suri Arshad ◽  
Abdul Rahman Omar ◽  
Mohd Hair Bejo ◽  
Faruku Bande ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Type I ◽  
Type Ii ◽  
Feline Coronavirus

scholarly journals Differential effect of cholesterol on type I and II feline coronavirus infection

2015 ◽  
Vol 161 (1) ◽  
pp. 125-133 ◽  
Author(s):  
Tomomi Takano ◽  
Yui Satomi ◽  
Yuu Oyama ◽  
Tomoyoshi Doki ◽  
Tsutomu Hohdatsu
Keyword(s):  
Differential Effect ◽  
Type I ◽  
Coronavirus Infection ◽  
Feline Coronavirus

scholarly journals Comparative Genomic Analyses and CRISPR-Cas Characterization of Cutibacterium acnes Provide Insights Into Genetic Diversity and Typing Applications

2021 ◽  
Vol 12 ◽  
Author(s):  
Natalia Cobian ◽  
Allison Garlet ◽  
Claudio Hidalgo-Cantabrana ◽  
Rodolphe Barrangou
Keyword(s):  
Genetic Diversity ◽  
Critical Role ◽  
Gene Families ◽  
Comparative Genomic ◽  
Type I ◽  
Skin Microbiome ◽  
Competitive Growth ◽  
Key Factors ◽  
Cutibacterium Acnes ◽  
Health And Disease

Cutibacterium acnes is an important member of the human skin microbiome and plays a critical role in skin health and disease. C. acnes encompasses different phylotypes that have been found to be associated with different skin phenotypes, suggesting a genetic basis for their impact on skin health. Here, we present a comprehensive comparative analysis of 255 C. acnes genomes to provide insights into the species genetic diversity and identify unique features that define various phylotypes. Results revealed a relatively small and open pan genome (6,240 genes) with a large core genome (1,194 genes), and three distinct phylogenetic clades, with multiple robust sub-clades. Furthermore, we identified several unique gene families driving differences between distinct C. acnes clades. Carbohydrate transporters, stress response mechanisms and potential virulence factors, potentially involved in competitive growth and host colonization, were detected in type I strains, which are presumably responsible for acne. Diverse type I-E CRISPR-Cas systems and prophage sequences were detected in select clades, providing insights into strain divergence and adaptive differentiation. Collectively, these results enable to elucidate the fundamental differences among C. acnes phylotypes, characterize genetic elements that potentially contribute to type I-associated dominance and disease, and other key factors that drive the differentiation among clades and sub-clades. These results enable the use of comparative genomics analyses as a robust method to differentiate among the C. acnes genotypes present in the skin microbiome, opening new avenues for the development of biotherapeutics to manipulate the skin microbiota.

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