A novel porcine kobuvirus emerged in piglets with severe diarrhoea in China

2017 ◽  
Vol 64 (4) ◽  
pp. 1030-1036 ◽  
Author(s):  
S.-L. Zhai ◽  
H. Zhang ◽  
T. Lin ◽  
S.-N. Chen ◽  
X. Zhou ◽  
...  
Keyword(s):  
Porcine Kobuvirus ◽  
Severe Diarrhoea

scholarly journals Factors associated with typical enteropathogenic Escherichia coli infection among children <5 years old with moderate-to-severe diarrhoea in rural western Kenya, 2008–2012

2020 ◽  
Vol 148 ◽  
Author(s):  
K. Fagerli ◽  
R. Omore ◽  
S. Kim ◽  
J. B. Ochieng ◽  
T. L. Ayers ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Severe Diarrhoea ◽  
Western Kenya ◽  
Factors Associated ◽  
Case Comparison ◽  
Escherichia Coli Infection ◽  
Logistic Regressions ◽  
Stool Specimens ◽  
Polymerase Chain

Abstract Typical enteropathogenic Escherichia coli (tEPEC) infection is a major cause of diarrhoea and contributor to mortality in children <5 years old in developing countries. Data were analysed from the Global Enteric Multicenter Study examining children <5 years old seeking care for moderate-to-severe diarrhoea (MSD) in Kenya. Stool specimens were tested for enteric pathogens, including by multiplex polymerase chain reaction for gene targets of tEPEC. Demographic, clinical and anthropometric data were collected at enrolment and ~60-days later; multivariable logistic regressions were constructed. Of 1778 MSD cases enrolled from 2008 to 2012, 135 (7.6%) children tested positive for tEPEC. In a case-to-case comparison among MSD cases, tEPEC was independently associated with presentation at enrolment with a loss of skin turgor (adjusted odds ratio (aOR) 2.08, 95% confidence interval (CI) 1.37–3.17), and convulsions (aOR 2.83, 95% CI 1.12–7.14). At follow-up, infants with tEPEC compared to those without were associated with being underweight (OR 2.2, 95% CI 1.3–3.6) and wasted (OR 2.5, 95% CI 1.3–4.6). Among MSD cases, tEPEC was associated with mortality (aOR 2.85, 95% CI 1.47–5.55). This study suggests that tEPEC contributes to morbidity and mortality in children. Interventions aimed at defining and reducing the burden of tEPEC and its sequelae should be urgently investigated, prioritised and implemented.

scholarly journals Phylogenetic Analysis of Kobuvirus and Astrovirus From Korean Wild Boars: 2016-2018

2021 ◽  
Author(s):  
Jihye Shin ◽  
SeEun Choe ◽  
Bang-Hun Hyun ◽  
Dong-Jun An
Keyword(s):  
Phylogenetic Analysis ◽  
Phylogenetic Tree ◽  
Porcine Kobuvirus ◽  
Phylogenetic Tree Analysis ◽  
Tree Analysis ◽  
Wild Boars ◽  
Porcine Astrovirus ◽  
The One

Abstract The prevalence of porcine kobuvirus (PKoV) and porcine astrovirus (PAstV) in 845 Korean wild boars (KWB) during 2016-2018 were 28.0% and 10.6%, respectively, and co-infection of two viruses showed 5.1%. Phylogenetic tree analysis also revealed that 236 PKoVs from KWB were divided to diverse lineages within Aichivirus C group but the one strain (WKoV16CN-8627) was included the same cluster with bovine kobuvirus (Achivirus B). Eighty-nine PAstVs from KWB was belonged predominantly to lineage PAstV4 and only one strain (WAst17JN-10931) included novel to lineage PAstV2. Two viruses are epidemic more in young (≤ 12 months) than in old pigs (> 12 months).

Prevalence, seasonality and severity of disease caused by pathogenic Escherichia coli in children with diarrhoea in Bolivia

2013 ◽  
Vol 62 (11) ◽  
pp. 1697-1706 ◽  
Author(s):  
Lucia Gonzales ◽  
Enrique Joffre ◽  
Rosario Rivera ◽  
Åsa Sjöling ◽  
Ann-Mari Svennerholm ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Antibiotic Resistance ◽  
Severe Disease ◽  
Severe Diarrhoea ◽  
E Coli ◽  
Number Of Children ◽  
Severity Of Disease ◽  
Positive Stool ◽  
Pathogenic Escherichia Coli ◽  
Stool Samples

The prevalence of infection caused by different categories of diarrhoeagenic E. coli (DEC) strains, including enteroaggregative (EAEC), enteropathogenic (EPEC), enterotoxigenic (ETEC), enteroinvasive (EIEC) and enterohaemorrhagic (EHEC) E. coli, in children who suffered from diarrhoea (n = 3943) or did not have diarrhoea (n = 1026) were analysed in two areas in Bolivia over a period of 4 years. We also analysed the seasonality of DEC infections and severity of diarrhoea in children with DEC infection and compared antibiotic resistance in DEC strains isolated from children with and without diarrhoea. Stool samples were analysed for the presence of DEC by culturing followed by PCR. The most prevalent DEC categories in samples from the children were: EAEC (11.2 %); ETEC (6.6 %); EPEC (5.8 %); and EIEC and EHEC (<1 %). DEC strains were isolated significantly more often from diarrhoea cases (21.6 %) than from controls (17.6 %; P = 0.002). The number of children with diarrhoea associated with EAEC, EPEC and ETEC infections peaked in the Bolivian winter (April–September), although the proportion of DEC-positive stool samples was higher during the warm rainy season (October–March). High levels of antibiotic resistance were detected among the DEC strains. In particular, resistance to tetracycline and sulfamethoxazole–trimethoprim was significantly higher in strains isolated from individuals with diarrhoea than in samples from controls. The severity of disease in children infected with EAEC, EPEC and ETEC varied from mild to severe diarrhoea, although disease severity did not differ significantly between the different DEC categories. ETEC, EPEC and EAEC are commonly found in Bolivia and may cause severe disease in children.

The Use of a Soy Isolate Based Formula in the Treatment of Infantile Diarrhoea

1981 ◽  
Vol 9 (3) ◽  
pp. 232-235 ◽  
Author(s):  
B T Naidoo ◽  
I Chunterpurshad ◽  
A B G Mahyoodeen ◽  
G Pather
Keyword(s):  
Lactose Intolerance ◽  
Response Rate ◽  
Recovery Phase ◽  
Cow’S Milk ◽  
Intravenous Therapy ◽  
Severe Diarrhoea ◽  
Infantile Diarrhoea ◽  
Cow's Milk ◽  
Soy Isolate

Lactose intolerance interferes with the recovery phase in patients with severe diarrhoea. A controlled comparison of a lactose-free soy isolate formula (Isomil®) and a standard cow's milk-based formula in 112 infants with severe diarrhoea showed a significant advantage for the lactose-free formula. All the infants were dehydrated on admission and required initial intravenous therapy. The response rate in the two groups was, respectively, 93% and 75%.

scholarly journals Pathogen‐specific risk of seizure in children with moderate‐to‐severe diarrhoea: Case control study with follow‐up

2020 ◽  
Vol 25 (8) ◽  
pp. 1032-1042
Author(s):  
Farzana Afroze ◽  
Sumon Kumar Das ◽  
Shahnawaz Ahmed ◽  
Monira Sarmin ◽  
Nusrat Jahan Shaly ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Severe Diarrhoea ◽  
Specific Risk ◽  
Control Study

Microsporidiosis

2011 ◽  
Author(s):  
Louis M. Weiss
Keyword(s):  
Cerebrospinal Fluid ◽  
Human Disease ◽  
Male Infant ◽  
Organ System ◽  
Ocular Infection ◽  
Encephalitozoon Cuniculi ◽  
Severe Diarrhoea ◽  
Wide Range ◽  
Tract Involvement ◽  
The Brain

The class or order Microsporidia was elevated in to the phylum Microspora by Sprague and Vavra (1997) and Sprague and Becnel (1998) subsequently suggested that the term Microsporidia instead be used for the phylum name. Miicrosporidia, i.e. Nosema bombycis, were first described about 150 years ago as the cause of the disease pebrine in silkworms. In 1922, there were descriptions of gram-positive spores consistent with microspordiosis in the brain of rabbits that were being used for investigations on poliomyelitis (Wright and Craighead 1922). From 1923 to 1926, Levaditi and colleagues studied the organisms seen by Wright and Craighead, which they named Encephalitozoon cuniculi, recognizing them as Microsporidia and demonstrating their lack of host specificity by transmitting infections from rabbits to mice, rats and dogs (Levaditi et al. 1923). Microsporidia were clearly confirmed of being a cause of human disease in 1959 (Matsubayashi et al. 1959), when they were isolated from the cerebrospinal fluid of a 9 year old boy with encephalitis with seizures, coma, and fever lasting about 25 days. Bergquist et al. (1984) reported a 2 year old child with encephalitis and seizures who had Encephalitozoon spores in urine and Margileth et al. (1973) isolated the microsporidium Anncaliia (Nosema) connori from a 4 month old athymic male infant who died with severe diarrhoea and malabsorption. Microsporidia can produce a wide range of clinical diseases. A diarrhoeal syndrome associated with microsporidiosis and HIV infection was reported by Desportes et al. (1985) and the number of articles describing human disease increased rapidly after 1990. In addition to gastrointestinal tract involvement, it has been recognized that Microsporidia can infect virtually any organ system; and patients with encephalitis, ocular infection, sinusitis, myositis, and disseminated infection are well described in the literature.

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