Characterization of two new human leukocyte antigen alleles: HLA‐A *02:982 and HLA‐C*04:441

HLA ◽  
2021 ◽  
Author(s):  
Maria Loginova ◽  
Daria Smirnova ◽  
Svetlana Kutyavina ◽  
Konstanin Kashin ◽  
Igor Paramonov
Keyword(s):  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Leukocyte Antigen

Characterization of a novel human leukocyte antigen-DQB1 allele, DQB1*030504+

2006 ◽  
Vol 68 (2) ◽  
pp. 189-190 ◽  
Author(s):  
M. C. Visschedijk ◽  
P. van den Boomgaard ◽  
N. Kouprie ◽  
S. P. M. Lems ◽  
B. G. Hepkema
Keyword(s):  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Dqb1 Allele

Identification and characterization of human leukocyte antigen class I ligands in renal cell carcinoma cells

2011 ◽  
Vol 5 (9-10) ◽  
pp. 569-569
Author(s):  
Barbara Seliger ◽  
Sven P. Dressler ◽  
Chiara Massa ◽  
Christian V. Recktenwald ◽  
Florian Altenberend ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Human Leukocyte Antigen ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Human Leukocyte Antigen Class ◽  
Human Leukocyte ◽  
Carcinoma Cells ◽  
Leukocyte Antigen ◽  
Identification And Characterization

Characterization of two new human leukocyte antigen class I alleles B*0829 and Cw*0736

2006 ◽  
Vol 68 (3) ◽  
pp. 267-268 ◽  
Author(s):  
A. Balas ◽  
M. Alonso-Nieto ◽  
F. García-Sánchez ◽  
J. L. Vicario
Keyword(s):  
Human Leukocyte Antigen ◽  
Human Leukocyte Antigen Class ◽  
Human Leukocyte ◽  
Class I ◽  
Leukocyte Antigen ◽  
Leukocyte Antigen Class I

scholarly journals Identification and characterization of human leukocyte antigen class I ligands in renal cell carcinoma cells

PROTEOMICS ◽  
2011 ◽  
Vol 11 (12) ◽  
pp. 2528-2541 ◽  
Author(s):  
Barbara Seliger ◽  
Sven P. Dressler ◽  
Chiara Massa ◽  
Christian V. Recktenwald ◽  
Florian Altenberend ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Human Leukocyte Antigen ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Human Leukocyte Antigen Class ◽  
Human Leukocyte ◽  
Carcinoma Cells ◽  
Leukocyte Antigen ◽  
Identification And Characterization

Immunoglobulin isotype-specific characterization of anti-human leukocyte antigen antibodies eluted from explanted renal allografts

2007 ◽  
Vol 68 (6) ◽  
pp. 500-506 ◽  
Author(s):  
Falko M. Heinemann ◽  
Ioana Roth ◽  
Vera Rebmann ◽  
Marie-Luise Arnold ◽  
Oliver Witzke ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Renal Allografts ◽  
Immunoglobulin Isotype ◽  
Leukocyte Antigen

P094 Human leukocyte antigen characterization of a Kumeyaay ethnic group community in Baja California, Mexico

2016 ◽  
Vol 77 ◽  
pp. 107
Author(s):  
Brenda L. Alvarado ◽  
Karol Carrillo ◽  
Horacio Almanza ◽  
Hilario Flores ◽  
Carmen Alaez
Keyword(s):  
Human Leukocyte Antigen ◽  
Ethnic Group ◽  
Baja California ◽  
Human Leukocyte ◽  
Leukocyte Antigen

scholarly journals Characterization of 108 Genomic DNA Reference Materials for 11 Human Leukocyte Antigen Loci

2018 ◽  
Vol 20 (5) ◽  
pp. 703-715 ◽  
Author(s):  
Maria P. Bettinotti ◽  
Deborah Ferriola ◽  
Jamie L. Duke ◽  
Timothy L. Mosbruger ◽  
Nikolaos Tairis ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Reference Materials ◽  
Genomic Dna ◽  
Human Leukocyte ◽  
Leukocyte Antigen

scholarly journals Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens.

1992 ◽  
Vol 176 (2) ◽  
pp. 327-337 ◽  
Author(s):  
E Baixeras ◽  
B Huard ◽  
C Miossec ◽  
S Jitsukawa ◽  
M Martin ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Nk Cells ◽  
Lymphocyte Activation ◽  
Human Leukocyte ◽  
Class Ii ◽  
Hla Class Ii ◽  
Leukocyte Antigen ◽  
Initial Characterization ◽  
Lymphocyte Activation Gene

The lymphocyte activation gene 3 (LAG-3), expressed in human activated T and natural killer (NK) cells, is closely related to CD4 at the gene and protein levels. We report here the initial characterization of the LAG-3-encoded protein. We have generated two monoclonal antibodies after immunization of mice with a 30-amino acid peptide that corresponds to an exposed extra loop region present in the LAG-3 immunoglobulin-like first domain. The reactivity of these reagents is directed against LAG-3 since they recognize both membrane-expressed and soluble recombinant LAG-3 molecules produced in a baculovirus expression system. The two antibodies are likely to react with the same or closely related epitope (termed LAG-3.1) exposed on the LAG-3 first domain extra loop, as assessed in competition experiments on LAG-3-expressing activated lymphocytes. Cellular distribution analysis indicated that the LAG-3.1 epitope is expressed on activated T (both CD4+ and CD8+ subsets) and NK cells, and not on activated B cells or monocytes. In immunoprecipitation experiments performed on activated T and NK cell lysates, a 70-kD protein was detected after SDS-PAGE analysis. 45-kD protein species were also immunoprecipitated. Both the 70- and 45-kD proteins were shown to be N-glycosylated. In Western blot analysis, only the former molecule was recognized by the anti-LAG-3 antibodies, demonstrating that it is LAG-3 encoded. These anti-LAG-3 antibodies were used to investigate whether the LAG-3 protein interacts with the CD4 ligands. By using a high-level expression cellular system based on COS-7 cell transfection with recombinant CDM8 vectors and a quantitative cellular adhesion assay, we demonstrate that rosette formation between LAG-3-transfected COS-7 cells and human leukocyte antigen (HLA) class II-bearing B lymphocytes is specifically dependent on LAG-3/HLA class II interaction. In contrast to CD4, LAG-3 does not bind the human immunodeficiency virus gp120. This initial characterization will guide further studies on the functions of this molecule, which may play an important role in immune responses mediated by T and NK lymphocytes.

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