scholarly journals Influence of HLA-DR polymorphism and allergic sensitization on humoral immune responses to intact pneumococcus in a transgenic mouse model

HLA ◽  
2016 ◽  
Vol 88 (1-2) ◽  
pp. 25-34 ◽  
Author(s):  
Y. H. Sheen ◽  
G. Rajagopalan ◽  
C. M. Snapper ◽  
H. Kita ◽  
C.-I. Wi ◽  
...  
Keyword(s):  
Mouse Model ◽  
Immune Responses ◽  
Transgenic Mouse ◽  
Allergic Sensitization ◽  
Transgenic Mouse Model ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Hla Dr

The role of mouse strain and Th1/Th2 immune responses in the α1,2-fucosyltransferase transgenic mouse model of colitis

2001 ◽  
Vol 120 (5) ◽  
pp. A123
Author(s):  
Ashley M. Miller ◽  
Peter R. Elliott ◽  
William Connell ◽  
Steven Brown ◽  
Paul V. Desmond ◽  
...  
Keyword(s):  
Mouse Model ◽  
Immune Responses ◽  
Transgenic Mouse ◽  
Mouse Strain ◽  
Transgenic Mouse Model

HLA-DR polymorphisms influencein vivoresponses to staphylococcal toxic shock syndrome toxin-1 in a transgenic mouse model

HLA ◽  
2016 ◽  
Vol 89 (1) ◽  
pp. 20-28 ◽  
Author(s):  
A. Krogman ◽  
A. Tilahun ◽  
C. S. David ◽  
V. R. Chowdhary ◽  
M. P. Alexander ◽  
...  
Keyword(s):  
Mouse Model ◽  
Transgenic Mouse ◽  
Toxic Shock Syndrome ◽  
Transgenic Mouse Model ◽  
Toxic Shock ◽  
Hla Dr ◽  
Toxic Shock Syndrome Toxin ◽  
Staphylococcal Toxic Shock Syndrome

scholarly journals The effect of sex on immune responses to a homocitrullinated peptide in the DR4-transgenic mouse model of Rheumatoid Arthritis

2020 ◽  
Vol 3 ◽  
pp. 100053
Author(s):  
Ewa Cairns ◽  
Sheri Saunders ◽  
David A. Bell ◽  
Garth Blackler ◽  
Patrick Lac ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Mouse Model ◽  
Immune Responses ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model

scholarly journals Anti-Human CD4 Induces Peripheral Tolerance in a Human CD4+, Murine CD4−, HLA-DR+Advanced Transgenic Mouse Model

2002 ◽  
Vol 169 (6) ◽  
pp. 2947-2955 ◽  
Author(s):  
Rüdiger Laub ◽  
Rene Brecht ◽  
Martina Dorsch ◽  
Ulrich Valey ◽  
Kerstin Wenk ◽  
...  
Keyword(s):  
Mouse Model ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Peripheral Tolerance ◽  
Hla Dr

scholarly journals Strong anti-viral responses in pediatric COVID-19 patients in South Brazil

2021 ◽  
Author(s):  
Tiago Fazolo ◽  
Karina Lima ◽  
Julia C. Fontoura ◽  
Priscila Oliveira de Souza ◽  
Gabriel Hilario ◽  
...  
Keyword(s):  
T Cell ◽  
Immune Responses ◽  
T Cell Responses ◽  
Humoral Immune ◽  
Cell Responses ◽  
Humoral Immune Responses ◽  
Hla Dr ◽  
Data Points ◽  
Viral Responses ◽  
Immune Profiling

AbstractEpidemiological evidence that COVID-19 manifests as a milder disease in children compared to adults has been reported by numerous studies, but the mechanisms underlying this phenomenon have not been characterized. It is still unclear how frequently children get infected, and/or generate immune responses to SARS-CoV-2. We have performed immune profiling of pediatric and adult COVID-19 patients in Brazil, producing over 38 thousand data points, asking if cellular or humoral immune responses could help explain milder disease in children. In this study, pediatric COVID-19 patients presented high viral titers. Though their non-specific immune profile was dominated by naive, non-activated lymphocytes, their dendritic cells expressed high levels of HLA-DR and were low in CX3CR1, indicating competence to generate immune responses that are not targeted to inflamed tissue. Finally, children formed strong specific antibody and T cell responses for viral structural proteins. Children’s T cell responses differed from adults in that their CD8+ TNFα+ T cell responses were low for S peptide but significantly higher against N and M peptide pools. Altogether, our data support a scenario in which SARS-CoV-2 infected children may contribute to transmission, though generating strong and differential responses to the virus that might associate with protection in pediatric COVID-19 presentation.

The role of mouse strain and Th1/Th2 immune responses in the α1,2-fucosyltransferase transgenic mouse model of colitis

2001 ◽  
Vol 120 (5) ◽  
pp. A123-A123
Author(s):  
A MILLER ◽  
P ELLIOTT ◽  
W CONNELL ◽  
S BROWN ◽  
P DESMOND ◽  
...  
Keyword(s):  
Mouse Model ◽  
Immune Responses ◽  
Transgenic Mouse ◽  
Mouse Strain ◽  
Transgenic Mouse Model
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