Genetic variants of 17q21 are associated with childhood-onset asthma and related phenotypes in a northeastern Han Chinese population: a case-control study

2014 ◽  
Vol 83 (5) ◽  
pp. 330-336 ◽  
Author(s):  
X. Yu ◽  
C. Yu ◽  
Z. Ren ◽  
Y. Deng ◽  
J. Song ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Chinese Population ◽  
Case Control Study ◽  
Case Control ◽  
Han Chinese ◽  
Childhood Onset ◽  
Han Chinese Population ◽  
Control Study

scholarly journals Association study between genetic variants and the risk of schizophrenia in the Chinese population based on GWAS-implicated 6p21.3–23.1 human genome region: a case-control study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Gangqin Li ◽  
Jie Dai ◽  
Hao Liu ◽  
Yushan Lin ◽  
Qiaoni Liu ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Chinese Population ◽  
Protective Factor ◽  
Case Control Study ◽  
Genetic Model ◽  
Disease Risk ◽  
Case Control ◽  
Han Chinese ◽  
Han Chinese Population ◽  
Control Study

Abstract Background Schizophrenia is a polygenic disease; however, the specific risk genetic variants of schizophrenia are still largely unknown. Single nucleotide polymorphism (SNP) is important genetic factor for the susceptibility of schizophrenia. Investigating individual candidate gene contributing to disease risk remains important. Methods In a case-control study, five SNPs located in 6p21.3-p23.1 including rs2021722 in human leukocyte antigen (HLA) locus and rs107822, rs383711, rs439205 and rs421446 within the upstream of microRNA-219a-1 were genotyped in 454 schizophrenia patients and 445 healthy controls to investigate the possible association between the loci and schizophrenia in a Han Chinese population. Results Our results showed significant associations between the rs2021722 and schizophrenia in allele (A vs. G: adjusted OR = 1.661, 95%CI = 1.196–2.308), co-dominant (AG vs. GG: OR = 1.760, 95%CI = 1.234–2.510) and dominant genetic model (AG + AA vs. GG: OR = 1.756, 95%CI = 1.237–2.492), respectively. Haplotype analysis showed that TGGT and CAAC were protective factor for schizophrenia compared with TAAC haplotype (OR = 0.324, 95% CI = 0.157–0.672; OR = 0.423, 95% CI = 0.199–0.900). Conclusions These findings indicate that rs2021722 in HLA locus might be involved in pathogenesis of schizophrenia and that genotypes AG and allele A of the locus are risk factors for schizophrenia in the Han Chinese population, confirming the association between immune system and schizophrenia.

scholarly journals Association between Two Resistin Gene Polymorphisms and Metabolic Syndrome in Jilin, Northeast China: A Case-Control Study

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Yingli Fu ◽  
Yaqin Yu ◽  
Yanhua Wu ◽  
Yueyue You ◽  
Yangyu Zhang ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Case Control Study ◽  
International Diabetes Federation ◽  
Case Control ◽  
Han Chinese ◽  
Jilin Province ◽  
Han Chinese Population ◽  
Control Study

Metabolic syndrome (MetS) is a significant health care problem worldwide and is characterized by increased fasting glucose and obesity. Resistin is a protein hormone produced both by adipocytes and immunocompetent cells, including those residing in adipose tissue, and is believed to modulate glucose tolerance and insulin action. This study examined the association of resistin gene polymorphisms, rs1862513 and rs3745368, and related haplotypes with the development of metabolic syndrome in a Han Chinese population. This case-control study was performed on 3792 subjects, including 1771 MetS cases and 2021 healthy controls from the Jilin province of China. Metabolic syndrome was defined according to the criteria of the International Diabetes Federation (IDF). Logistic regression analysis was used to estimate the relationship between gene polymorphism and MetS. Our results showed that there were no significant associations between MetS and the genotype distributions in four kinds of inheritance models, allele frequencies, and related haplotypes of resistin gene polymorphisms rs1862513 and rs3745368 (allpvalues > 0.05). Based on our study findings, we concluded that mutations in resistin genes are not associated with the presence of MetS in a Han Chinese population from Jilin province in China.

A Case-Control Study of ABCB1, ABCB6, and ABCG1 Polymorphisms and Schizophrenia in a Han Chinese Population

2019 ◽  
Vol 78 (3) ◽  
pp. 113-117 ◽  
Author(s):  
Gaini Ma ◽  
Xiaoye Huang ◽  
Yan Bi ◽  
Fei Xu ◽  
Weibo Niu ◽  
...  
Keyword(s):  
Chinese Population ◽  
Case Control Study ◽  
Case Control ◽  
Han Chinese ◽  
Han Chinese Population ◽  
Control Study

scholarly journals Genetic polymorphisms of NOS2 and predisposition to fracture non-union: A case control study based on Han Chinese population

PLoS ONE ◽  
2018 ◽  
Vol 13 (3) ◽  
pp. e0193673 ◽  
Author(s):  
Wei Huang ◽  
Kun Zhang ◽  
Yangjun Zhu ◽  
Zhan Wang ◽  
Zijun Li ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Chinese Population ◽  
Case Control Study ◽  
Case Control ◽  
Han Chinese ◽  
Han Chinese Population ◽  
Non Union ◽  
Control Study
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