“Easy” and “hard” issues: Attitude extremity and a role of the need to evaluate

2021 ◽  
Author(s):  
Heysung Lee
Keyword(s):  
Need To Evaluate ◽  
Attitude Extremity

scholarly journals Eat Tasty and Healthy: Role of Polyphenols in Functional Foods

2021 ◽  
Author(s):  
Catarina Bessa-Pereira ◽  
Ricardo Dias ◽  
Elsa Brandão ◽  
Nuno Mateus ◽  
Victor de Freitas ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Phenolic Compounds ◽  
Functional Foods ◽  
Unmet Need ◽  
Protective Effects ◽  
Immune Reactions ◽  
Public Health Burden ◽  
Organoleptic Characteristics ◽  
Need To Evaluate

Adverse reactions to food such as allergies and celiac disease are increasingly recognized as a growing public health burden. There is currently no cure for these diseases so that there is an unmet need to evaluate different nutritional approaches aiming at improving the quality of life of affected patients and their families. In this context, healthy promising nature-derived compounds, most of which contained in fruits and vegetables, have been studied as an alternative to attenuate the epidemic. Indeed, phenolic compounds have become an emerging field of interest in nutrition in the last decades. A growing build of research suggests that phenolic compounds inhibit pro-inflammatory transcription factors by interacting with proteins involved in gene expression and cell signaling, leading to protective effects against many inflammation-mediated chronic diseases. However, the use of phenolic compounds as attenuating agents of immune reactions to food has to be aligned to the organoleptic characteristics of food, since many compounds present unpleasant taste properties, namely bitter taste and astringency. In this framework, tasty but healthy phenolic compounds arise as attractive ingredients in the design and formulation of functional foods. This book chapter is focused on revisiting the organoleptic properties of phenolic compounds while evaluating the role of these compounds in health promoting actions, namely the management of immune reactions to food such as Food Allergies and Celiac Disease.

scholarly journals Role of biomarkers in predicting the occurrence of thyroid neoplasms in radiation-exposed children

2018 ◽  
Vol 25 (4) ◽  
pp. 481-491
Author(s):  
Joseph M Shulan ◽  
Leonid Vydro ◽  
Arthur B Schneider ◽  
Dan V Mihailescu
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Nodules ◽  
Subsequent Development ◽  
Thyroid Neoplasms ◽  
Childhood Cancer Survivors ◽  
Malignant Neoplasms ◽  
Increased Risk ◽  
Need To Evaluate

With increasing numbers of childhood cancer survivors who were treated with radiation, there is a need to evaluate potential biomarkers that could signal an increased risk of developing thyroid cancer. We aimed to examine the relationships between thyrotropin and thyroglobulin levels and the risk of developing thyroid nodules and cancer in a cohort of radiation-exposed children. 764 subjects who were irradiated in the neck area as children were examined and followed for up to 25 years. All subjects underwent a clinical examination, measurements of thyrotropin, thyroglobulin levels and thyroid imaging. At baseline, 216 subjects had thyroid nodules and 548 did not. Of those with nodules, 176 underwent surgery with 55 confirmed thyroid cancers. During the follow-up, 147 subjects developed thyroid nodules including 22 with thyroid cancer. Thyroglobulin levels were higher in subjects with prevalent thyroid nodules (26.1 ng/mL vs 9.37 ng/mL; P < 0.001) and in those who had an initial normal examination but later developed thyroid nodules (11.2 ng/mL vs 8.87 ng/mL; P = 0.017). There was no relationship between baseline thyrotropin levels and the prevalent presence or absence of thyroid nodules, whether a prevalent neoplasm was benign or malignant, subsequent development of thyroid nodules during follow-up or whether an incident nodule was benign or malignant. In conclusion, in radiation-exposed children, higher thyroglobulin levels indicated an increased risk of developing thyroid nodules but did not differentiate between benign and malignant neoplasms. There was no association between the baseline TSH level and the risk of developing thyroid nodules or cancer.

i2Flex and the Community of Inquiry Framework

2016 ◽  
pp. 115-129
Author(s):  
Antonia Fyrigou
Keyword(s):  
Best Practices ◽  
Student Learning ◽  
Community Of Inquiry ◽  
Teaching Methodology ◽  
Need To Evaluate ◽  
Community Of Inquiry Framework ◽  
French Class ◽  
New Generation ◽  
Unique Potential

In this chapter the goal is to describe my implementation of the i2Flex in two consecutive academic years in an attempt to meet more effectively the educational needs of the new generation students. Starting with the description of the i2Flex methodology in an IB French class as a member of the pilot i2Flex faculty at ACS Athens, I will present the instructional (re-)design of my Moodle shell to reflect the new teaching methodology, and the need to evaluate this pilot year via an appropriate framework. Then, I will describe the same class in the second year, from how i2Flex was at this point implemented to how it was evaluated and what data was collected from the students. Finally, the goal is to share under the umbrella of best practices how meaningful and efficient the i2Flex is, taking in consideration the new role of the teacher in and out of class and its unique potential for student learning.

scholarly journals Role of Piezoelectric Elements in Finding the Mechanical Properties of Solid Industrial Materials

2018 ◽  
Vol 8 (10) ◽  
pp. 1737 ◽  
Author(s):  
Arshed Mohammed ◽  
Sallehuddin Haris ◽  
Mohd Nuawi
Keyword(s):  
Mechanical Properties ◽  
State Of The Art ◽  
New Technology ◽  
Material Testing ◽  
Current Status ◽  
Piezoelectric Elements ◽  
Need To Evaluate ◽  
Recent Developments ◽  
The Many

Recent developments in ultrasonic material testing have increased the need to evaluate the current status of the different applications of piezoelectric elements (PEs). This research have reviewed state-of-the-art emerging new technology and the role of PEs in tests for a number of mechanical properties, such as creep, fracture toughness, hardness, and impact toughness, among others. In this field, importance is given to the following variables, namely, (a) values of the natural frequency to PEs, (b) type and dimensions of specimens, and (c) purpose of the tests. All these variables are listed in three tables to illustrate the nature of their differences in these kinds of tests. Furthermore, recent achievements in this field are emphasized in addition to the many important studies that highlight the role of PEs.

scholarly journals A stone down below: a urethral stone causing acute urinary retention and renal failure

CJEM ◽  
2010 ◽  
Vol 12 (04) ◽  
pp. 377-380 ◽  
Author(s):  
Hanna Bielawska ◽  
Norman L. Epstein
Keyword(s):  
Case Reports ◽  
Disease Process ◽  
Common Disease ◽  
Initial Management ◽  
Tomographic Images ◽  
Computed Tomographic ◽  
Need To Evaluate ◽  
Urethral Stone ◽  
Therapeutic Considerations

ABSTRACTImpaction of a kidney stone in the male urethra is a rare sequela of an otherwise common disease process. Case reports of urethral stones in the recent literature are scarce. We report a case of a 48-year-old man who presented with an impacted urethral stone as a complication of nephrolithiasis. The pathology was twice missed, even with computed tomography showing the stone in the prostatic urethra, which highlights the challenges of making this diagnosis. We review the existing literature outlining the pathogenesis, clinical features and therapeutic considerations as they relate to urethral stones. We underscore the role of the emergency physician in the diagnosis and initial management of this entity, and draw attention to the need to evaluate not just the upper but also the lower genitourinary tracts when interpreting computed tomographic images obtained for the diagnosis of renal colic.

scholarly journals The Origins of the Stalingrad Victory: Psychological Aspect

2019 ◽  
pp. 155-164
Author(s):  
Aleksandr Strizoe
Keyword(s):  
Early Modern Period ◽  
Radical Change ◽  
Personal Initiative ◽  
The Everyday ◽  
Need To Evaluate ◽  
Active Defence ◽  
Red Army ◽  
Long Time ◽  
Rational Organization

Introduction. The article points out the need for a special study of psychological aspects of the reasons for the victory of the Red Army at Stalingrad, which for a long time remained undervalued due to the traditional attention of researchers paid to the role of ideological factors. These aspects are revealed in the process of radical change in the moods of soldiers and commanders of the Red Army in the period between the issuance of Order No. 227 in July 1942 and the formation of new urban combat tactics in the winter of 1942-1943. The author notes the need to evaluate measures of command and practices of soldiers’ and commanders’ behaviour in war, taking into account the achievements of modern psychology. Methods. The author presents a methodological scheme for analysing the process of changing moods, the transition from confusion and panic to the formation of readiness for active defence and attack. Its elements include studying adaptation to the everyday difficulties of war, interpersonal trust and rational organization of various aspects of life in war as prerequisites for a psychological break in the moods of soldiers and commanders. Analysis and results. The article emphasizes the role of formation of self-organization and liberation of personal initiative of soldiers as one of the manifestations of positive psychological changes. These changes are conceptualized in a new understanding of courage. Along with the ‘courage of self-sacrifice’ characteristic of archaic culture and traditional society, the ‘courage of self-affirmation’, which is rooted in the values of the Renaissance and the early modern period and focused on success in military confrontation and preservation of the lives of soldiers and commanders, arises and spreads. The emergence and spread of new psychological attitudes and orientations during the Stalingrad battle can be assessed as the beginning of moral and psychological break in the Red Army, the beginning of the formation of the ‘psychology of victory’ as a powerful mobilizing factor.

scholarly journals Counterpossible Reasoning in Physics

2021 ◽  
Vol 88 (5) ◽  
pp. 1113-1124
Author(s):  
Alastair Wilson
Keyword(s):  
Causal Structure ◽  
Third Way ◽  
The Third ◽  
The World ◽  
Need To Evaluate ◽  
Metaphysical Dependence

This article explores three ways in which physics may involve counterpossible reasoning. The first way arises when evaluating false theories: to say what the world would be like if the theory were true, we need to evaluate counterfactuals with physically impossible antecedents. The second way relates to the role of counterfactuals in characterizing causal structure: to say what causes what in physics, we need to make reference to physically impossible scenarios. The third way is novel: to model metaphysical dependence in physics, we need to consider counterfactual consequences of metaphysical impossibilities. Physics accordingly bears substantial and surprising counterpossible commitments.

i2Flex and the Community of Inquiry Framework

2016 ◽  
pp. 334-348
Author(s):  
Antonia Fyrigou
Keyword(s):  
Best Practices ◽  
Student Learning ◽  
Community Of Inquiry ◽  
Teaching Methodology ◽  
Need To Evaluate ◽  
Community Of Inquiry Framework ◽  
French Class ◽  
New Generation ◽  
Unique Potential

In this chapter the goal is to describe my implementation of the i2Flex in two consecutive academic years in an attempt to meet more effectively the educational needs of the new generation students. Starting with the description of the i2Flex methodology in an IB French class as a member of the pilot i2Flex faculty at ACS Athens, I will present the instructional (re-)design of my Moodle shell to reflect the new teaching methodology, and the need to evaluate this pilot year via an appropriate framework. Then, I will describe the same class in the second year, from how i2Flex was at this point implemented to how it was evaluated and what data was collected from the students. Finally, the goal is to share under the umbrella of best practices how meaningful and efficient the i2Flex is, taking in consideration the new role of the teacher in and out of class and its unique potential for student learning.

scholarly journals The Role of Epigenetic Functionalization of Implants and Biomaterials in Osseointegration and Bone Regeneration—A Review

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 5879
Author(s):  
Farah Asa’ad ◽  
Goda Pelanyte ◽  
Jincy Philip ◽  
Christer Dahlin ◽  
Lena Larsson
Keyword(s):  
Bone Regeneration ◽  
Alveolar Bone ◽  
Inflammatory Diseases ◽  
Standards Of Care ◽  
Epigenetic Mechanisms ◽  
Implant Surface ◽  
The Past ◽  
Need To Evaluate ◽  
Specific Search

The contribution of epigenetic mechanisms as a potential treatment model has been observed in cancer and autoimmune/inflammatory diseases. This review aims to put forward the epigenetic mechanisms as a promising strategy in implant surface functionalization and modification of biomaterials, to promote better osseointegration and bone regeneration, and could be applicable for alveolar bone regeneration and osseointegration in the future. Materials and Methods: Electronic and manual searches of the literature in PubMed, MEDLINE, and EMBASE were conducted, using a specific search strategy limited to publications in the last 5 years to identify preclinical studies in order to address the following focused questions: (i) Which, if any, are the epigenetic mechanisms used to functionalize implant surfaces to achieve better osseointegration? (ii) Which, if any, are the epigenetic mechanisms used to functionalize biomaterials to achieve better bone regeneration? Results: Findings from several studies have emphasized the role of miRNAs in functionalizing implants surfaces and biomaterials to promote osseointegration and bone regeneration, respectively. However, there are scarce data on the role of DNA methylation and histone modifications for these specific applications, despite being commonly applied in cancer research. Conclusions: Studies over the past few years have demonstrated that biomaterials are immunomodulatory rather than inert materials. In this context, epigenetics can act as next generation of advanced treatment tools for future regenerative techniques. Yet, there is a need to evaluate the efficacy/cost effectiveness of these techniques in comparison to current standards of care.

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