scholarly journals The effect of exercise on the protein profile of rat knee joint intra‐ and extra‐articular ligaments

2021 ◽  
Author(s):  
Yalda A. Kharaz ◽  
Helen Birch ◽  
Alexandra Chester ◽  
Eleanor Alchorne ◽  
Deborah Simpson ◽  
...  
Keyword(s):  
Knee Joint ◽  
Protein Profile ◽  
Articular Ligaments

scholarly journals The effect of exercise on the protein profile of rat knee joint intra- and extra-articular ligaments

2018 ◽  
Vol 26 ◽  
pp. S171
Author(s):  
Y. Ashraf Kharaz ◽  
H. Birch ◽  
E. Allchorne ◽  
A. Chester ◽  
P. Clegg ◽  
...  
Keyword(s):  
Knee Joint ◽  
Protein Profile ◽  
Articular Ligaments

scholarly journals Correlation of Synovial Tissues Protein Abundance With Age and Menopause in Osteoarthritis and Knee Joint Injury of Female Patients

2021 ◽  
Author(s):  
Xiao Yang ◽  
Zhe Fu ◽  
qiuyu ren ◽  
Shuang Wang ◽  
Shuai Yin ◽  
...  
Keyword(s):  
Knee Joint ◽  
Clinical Outcomes ◽  
Knee Injury ◽  
Protein Profile ◽  
Joint Function ◽  
Joint Injury ◽  
Female Patients ◽  
Knee Oa ◽  
Epidemiological Surveys ◽  
Menopausal Women

Abstract BackgroundKnee injury and osteoarthritis (OA) are common articular disorders that affect numerous people of different ages, particularly menopausal women. Epidemiological surveys conclude that ladies gain a higher prevalence of OA than men, the menopausal women even get higher morbidity. However, studies about OA animal models suggest that the animals could remain a good joint function regardless of aging and menopause; age and menopause seem to have little effect on joint function. Thus, the study aimed to explore whether age and menopause will influence the clinical recovery of a knee joint in OA and injury women and the relevant mechanism by analyzing the proteome profile of synovial tissue (ST) samples.MethodsThe routine blood test and hormone levels were detected before the surgery. The ST samples of participants were collected during the surgery and 8 ST samples were used for proteome analysis. Just the day before and one month after the surgery, scores of Visual Analogue Score (VAS), Lysholm, The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) were used for assessing the functions of the affected knee. The relationship among proteome data, aging, estrogen level, and affected knee function were analyzed. ResultsAge, menopause and disorders of the knee were related to the clinical outcomes of knee OA and injuries of female patients. Proteome data revealed that the abundance of 174 proteins in old women was statistically different from those of young women. Similarly, compared to the menopausal women, about 120 proteins were significantly changed in the samples taken from premenopausal women. 58 proteins were shown to be insignificant different amounts in ST from knee OA women compared to knee injury ones. The reactions and pathways of these proteins were analyzed and visualized.ConclusionsAge and menopause showed a certain correlation with the protein profile of ST from OA or knee injury female patients, which indicated that the protein components might be affected by age and menopause. Besides, age and menopause also influenced the clinical outcomes of these patients after surgery therapy. Aging and menopause might take part in the regulation of remaining knee joint functions via modeling the ST protein expression.

Effects of Osmium Tetroxide on the Rabbit Knee Joint Normal Synovial Membrane

1987 ◽  
Vol 16 (1) ◽  
pp. 121-129
Author(s):  
M. Möttönen ◽  
M. Pantio ◽  
T. Nevalainen
Keyword(s):  
Knee Joint ◽  
Synovial Membrane ◽  
Osmium Tetroxide ◽  
Rabbit Knee

Protein profile of human perilymph: In search of markers for the diagnosis of perilymph fistula and other inner ear disease

1994 ◽  
Vol 111 (3) ◽  
pp. 273-280 ◽  
Author(s):  
I THALMANN ◽  
R KOHUT ◽  
J RYU ◽  
T COMEGYS ◽  
M SENARITA ◽  
...  
Keyword(s):  
Inner Ear ◽  
Protein Profile ◽  
Inner Ear Disease

Radiation synovectomy of the knee joint

2006 ◽  
Vol 45 (01) ◽  
pp. 57-61
Author(s):  
M. Puille ◽  
D. Steiner ◽  
R. Bauer ◽  
R. Klett
Keyword(s):  
Knee Joint ◽  
Lymph Nodes ◽  
Geometric Mean ◽  
Radiation Synovectomy ◽  
Real Activity ◽  
Anterior View ◽  
Inguinal Lymph Nodes ◽  
The Real ◽  
Therapeutic Modalities ◽  
Real Value

Summary Aim: Multiple procedures for the quantification of activity leakage in radiation synovectomy of the knee joint have been described in the literature. We compared these procedures considering the real conditions of dispersion and absorption using a corpse phantom. Methods: We simulated different distributions of the activity in the knee joint and a different extra-articular spread into the inguinal lymph nodes. The activity was measured with a gammacamera. Activity leakage was calculated by measuring the retention in the knee joint only using an anterior view, using the geometric mean of anterior and posterior views, or using the sum of anterior and posterior views. The same procedures were used to quantify the activity leakage by measuring the activity spread into the inguinal lymph nodes. In addition, the influence of scattered rays was evaluated. Results: For several procedures we found an excellent association with the real activity leakage, shown by an r² between 0.97 and 0.98. When the real value of the leakage is needed, e. g. in dosimetric studies, simultaneously measuring of knee activity and activity in the inguinal lymph nodes in anterior and posterior views and calculation of the geometric mean with exclusion of the scatter rays was found to be the procedure of choice. Conclusion: When measuring of activity leakage is used for dosimetric calculations, the above-described procedure should be used. When the real value of the leakage is not necessary, e. g. for comparing different therapeutic modalities, several of the procedures can be considered as being equivalent.

Load-Bearing in the Ovine Medial Tibial Condyle: Effect of Meniscectomy

1993 ◽  
Vol 06 (02) ◽  
pp. 100-104 ◽  
Author(s):  
D. M. Pickles ◽  
C. R. Bellenger
Keyword(s):  
Knee Joint ◽  
Contact Area ◽  
Mammalian Species ◽  
Total Removal ◽  
Load Bearing ◽  
Human Knee ◽  
Biochemical Effects ◽  
Pressure Sensitive ◽  
Medial Meniscectomy ◽  
Tibial Condyle

SummaryTotal removal of a knee joint meniscus is followed by osteoarthritis in many mammalian species. Altered load-bearing has been observed in the human knee following meniscectomy but less is known about biochemical effects of meniscectomy in other species. Using pressure sensitive paper in sheep knee (stifle) joints it was found that, for comparable loads, the load-bearing area on the medial tibial condyle was significantly reduced following medial meniscectomy. Also, for loads of between 50 N and 500 N applied to the whole joint, the slope of the regression of contact area against load was much smaller. Following medial meniscectomy, the ability to increase contact area as load increased was markedly reduced.The load bearing area on the medial tibial condyle was reduced following meniscectomy.

The Analysis of Proprioception Alteration during First Five Months after Anterior Cruciate Ligament Reconstruction

2018 ◽  
Vol 1 (84) ◽  
Author(s):  
Vilma Jurevičienė ◽  
Albertas Skurvydas ◽  
Juozas Belickas ◽  
Giedra Bušmanienė ◽  
Dovilė Kielė ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
Angular Velocity ◽  
Knee Joint ◽  
Cruciate Ligament ◽  
Position Sense ◽  
Joint Position Sense ◽  
Joint Position ◽  
Starting Position ◽  
Angular Velocities ◽  
Anterior Cruciate

Research  background  and  hypothesis.  Proprioception  is  important  in  the  prevention  of  injuries  as  reduced proprioception  is  one  of  the  factors  contributing  to  injury  in  the  knee  joint,  particularly  the  ACL.  Therefore, proprioception appears not only important for the prevention of ACL injuries, but also for regaining full function after ACL reconstruction.Research aim. The aim of this study was to understand how proprioception is recovered four and five months after anterior cruciate ligament (ACL) reconstruction.Research methods. The study included 15 male subjects (age – 33.7 ± 2.49 years) who had undergone unilateral ACL reconstruction with a semitendinosus/gracilis (STG) graft in Kaunas Clinical Hospital. For proprioceptive assessment, joint position sense (JPS) was measured on both legs using an isokinetic dynamometer (Biodex), at knee flexion of 60° and 70°, and at different knee angular velocities of 2°/s and 10°/s. The patients were assessed preoperatively and after 4 and 5 months, postoperatively.Research results. Our study has shown that the JPS’s (joint position sense) error scores  to a controlled active movement is significantly higher in injured ACL-deficient knee than in the contralateral knee (normal knee) before surgery and after four and five months of rehabilitation.  After 4 and 5 months of rehabilitation we found significantly lower values in injured knees compared to the preoperative data. Our study has shown that in injured knee active angle reproduction errors after 4 and 5 months of rehabilitation were higher compared with the ones of the uninjured knee. Proprioceptive ability on the both legs was  independent of all differences angles for target and starting position for movement. The knee joint position sense on both legs depends upon the rate of two different angular velocities and the mean active angle reproduction errors at the test of angular velocity slow speed was the highest compared with the fast angular velocity. Discussion and conclusions. In conclusion, our study shows that there was improvement in mean JPS 4 and 5 months after ACL reconstruction, but it did not return to normal indices.Keywords: knee joint, joint position sense, angular velocity, starting position for movement.

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