scholarly journals Longitudinal hypertrophic and transcriptional responses to high‐load eccentric‐concentric vs concentric training in males

2020 ◽  
Vol 30 (11) ◽  
pp. 2101-2115
Author(s):  
Joanne E. Mallinson ◽  
Tariq Taylor ◽  
Dumitru Constantin‐Teodosiu ◽  
Rudolf Billeter‐Clark ◽  
Despina Constantin ◽  
...  
Keyword(s):  
High Load ◽  
Transcriptional Responses ◽  
Concentric Training

CYCLOPS BHT

Alloy Digest ◽  
1965 ◽  
Vol 14 (2) ◽  
Keyword(s):  
Fracture Toughness ◽  
Corrosion Resistance ◽  
Elevated Temperature ◽  
High Speed ◽  
High Speed Steel ◽  
High Strength ◽  
Heat Treating ◽  
High Load ◽  
Structural Components ◽  
Temperature Performance

Abstract Cyclops BHT is a low-alloy martensitic high-speed steel of the molybdenum type recommended for high strength, high load structural components designed for elevated temperature service. This datasheet provides information on composition, physical properties, hardness, elasticity, and tensile properties as well as fracture toughness. It also includes information on high temperature performance and corrosion resistance as well as forming, heat treating, machining, and joining. Filing Code: SA-173. Producer or source: Cyclops Corporation.

VASCO M-50

Alloy Digest ◽  
1974 ◽  
Vol 23 (11) ◽  
Keyword(s):  
Elevated Temperature ◽  
Physical Properties ◽  
Surface Treatment ◽  
High Speed ◽  
High Speed Steel ◽  
High Strength ◽  
Heat Treating ◽  
High Load ◽  
Aisi 52100 ◽  
Aisi 52100 Steel

Abstract VASCO M-50 is a hardenable (martensitic), low-alloy high-speed steel developed primarily for high-strength, high-load components (such as bearings and gears) designed for elevated-temperature service. It may be used at temperatures up to 600 F; this is in contrast to AISI 52100 steel which may be used up to only 350 F. This datasheet provides information on composition, physical properties, hardness, and elasticity. It also includes information on forming, heat treating, machining, joining, and surface treatment. Filing Code: TS-278. Producer or source: Teledyne Vasco.

High Altitude hypoxia

2020 ◽  
Vol 17 ◽  
Author(s):  
Asma Babar ◽  
Kifayatullah Mengal ◽  
Abdul Hanan Babar ◽  
Shixin Wu ◽  
Mujahid Ali Shah ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
High Altitude ◽  
Molecular Mechanisms ◽  
Strong Association ◽  
Haemoglobin Concentration ◽  
Metabolic Reprogramming ◽  
Molecular Networks ◽  
Whole Genome ◽  
Gene Expressions ◽  
Transcriptional Responses

: The world highest and largest altitude area is called the Qinghai-Tibetan plateau (QTB), which harbors unique animal and plant species. Mammals that inhabit the higher altitude regions have adapted well to the hypoxic conditions. One of the main stressors at high altitude is hypoxia. Metabolic responses to hypoxia play important roles in cell survival strategies and some diseases. However, the homeostatic alterations that equilibrate variations in the demand and supply of energy to maintain organismal function in a prolonged low O2 environment persist partly understood, making it problematic to differentiate adaptive from maladaptive responses in hypoxia. Tibetans and yaks are two perfect examples innate to the plateau for high altitude adaptation. By the scan of the whole-genome, EPAS1 and EGLN1 were identified as key genes associated with sustained haemoglobin concentration in high altitude mammals for adaptation. The yak is a much more ancient mammal which has existed on QTB longer than humans, it is, therefore, possible that natural selection represented a diverse group of genes/pathways in yaks. Physiological characteristics are extremely informative in revealing molecular networks associated with inherited adaptation, in addition to the whole-genome adaptive changes at the DNA sequence level. Gene-expression can be changed by a variety of signals originating from the environment, and hypoxia is the main factor amongst them. The hypoxia-inducible factors (HIF-1α and EPAS1/HIF-2α) are the main regulators of oxygen in homeostasis which play a role as maestro regulators of adaptation in hypoxic reaction of molecular mechanisms. (Vague) The basis of this review is to present recent information regarding the molecular mechanism involved in hypoxia that regulates candidate genes and proteins. Many transcriptional responses toward hypoxia are facilitated by HIFs that change the number of gene expressions and help in angiogenesis, erythropoiesis, metabolic reprogramming and metastasis. HIFs also activate several signals highlighting a strong association between hypoxia, the misfolded proteins’ accumulation in the endoplasmic reticulum in stress and activation of unfolded protein response (UPR). It was observed that at high-altitude, pregnancies yield a low birth weight ∼100 g per1000 m of the climb. (Vague) It may involve variation in the events of energy-demanding, like protein synthesis. Prolonged hypobaric hypoxia causes placental ER stress, which in turn, moderates protein synthesis and reduces proliferation. Further, Cardiac hypertrophy by cytosolic Ca2+ raises and Ca2+/calmodulin, calcineurin stimulation, NF-AT3 pathway might be caused by an imbalance in Sarcoplasmic reticulum ER Ca2, might be adaptive in beginning but severe later.

scholarly journals Effects Of High-Load Versus High-Volume Resistance Training On Muscle Sarcoplasmic, Actin, And Myosin Protein Concentrations

2020 ◽  
Vol 52 (7S) ◽  
pp. 828-829
Author(s):  
Christopher G. Vann ◽  
Casey L. Sexton ◽  
Shelby C. Osburn ◽  
Morgan A. Smith ◽  
Carlton D. Fox ◽  
...  
Keyword(s):  
Resistance Training ◽  
High Volume ◽  
High Load ◽  
Volume Resistance

Ga-based liquid metal with good self-lubricity and high load-carrying capacity

2019 ◽  
Vol 129 ◽  
pp. 1-4 ◽  
Author(s):  
Jun Cheng ◽  
Yuan Yu ◽  
Jie Guo ◽  
Shuai Wang ◽  
Shengyu Zhu ◽  
...  
Keyword(s):  
Liquid Metal ◽  
Carrying Capacity ◽  
High Load ◽  
Load Carrying Capacity ◽  
Load Carrying

Biceps Disorder Rehabilitation for the Athlete: A Continuum of Moderate- to High-Load Exercises

2016 ◽  
Vol 45 (3) ◽  
pp. 642-650 ◽  
Author(s):  
Dorien Borms ◽  
Inge Ackerman ◽  
Pieter Smets ◽  
Glen Van den Berge ◽  
Ann M. Cools
Keyword(s):  
High Load
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