Clinical Interest of Ambulatory Assessment of Physical Activity and Walking Capacity in Peripheral Artery Disease

2015 ◽  
Vol 26 (7) ◽  
pp. 716-730 ◽  
Author(s):  
P.-Y. de Müllenheim ◽  
S. Chaudru ◽  
G. Mahé ◽  
J. Prioux ◽  
A. Le Faucheur
Keyword(s):  
Physical Activity ◽  
Peripheral Artery Disease ◽  
Ambulatory Assessment ◽  
Peripheral Artery ◽  
Walking Capacity ◽  
Clinical Interest ◽  
Artery Disease

scholarly journals Association between physical activity and walking capacity with cognitive function in peripheral artery disease patients

2018 ◽  
Vol 55 (5) ◽  
pp. 672-678 ◽  
Author(s):  
Bruno Remigio Cavalcante ◽  
Antonio H. Germano-Soares ◽  
Aline M. Gerage ◽  
Anthony Leicht ◽  
Rafael M. Tassitano ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cognitive Function ◽  
Peripheral Artery Disease ◽  
Peripheral Artery ◽  
Walking Capacity ◽  
Artery Disease

scholarly journals Influence of Peripheral Artery Disease and Statin Therapy on Apolipoprotein Profiles

2013 ◽  
Vol 2013 ◽  
pp. 1-7
Author(s):  
Andrew W. Gardner ◽  
Petar Alaupovic ◽  
Donald E. Parker ◽  
Polly S. Montgomery ◽  
Omar L. Esponda ◽  
...  
Keyword(s):  
Physical Activity ◽  
Myocardial Infarction ◽  
Statin Therapy ◽  
Peripheral Artery Disease ◽  
Apolipoprotein B ◽  
Ldl Cholesterol ◽  
Risk Profile ◽  
Peripheral Artery ◽  
Artery Disease ◽  
Plasma Apolipoprotein

Apolipoprotein B is a stronger predictor of myocardial infarction than LDL cholesterol, and it is inversely related to physical activity and modifiable with exercise training. As such, apolipoprotein measures may be of particular relevance for subjects with PAD and claudication. We compared plasma apolipoprotein profiles in 29 subjects with peripheral artery disease (PAD) and intermittent claudication and in 39 control subjects. Furthermore, we compared the plasma apolipoprotein profiles of subjects with PAD either treated (n=17) or untreated (n=12) with statin medications. For the apolipoprotein subparticle analyses, subjects with PAD had higher age-adjusted Lp-B:C (P<0.05) and lower values of Lp-A-I:A-II (P<0.05) than controls. The PAD group taking statins had lower age-adjusted values for apoB (P<0.05), Lp-A-II:B:C:D:E (P<0.05), Lp-B:E + Lp-B:C:E (P<0.05), Lp-B:C (P<0.05), and Lp-A-I (P<0.05) than the untreated PAD group. Subjects with PAD have impaired apolipoprotein profiles than controls, characterized by Lp-B:C and Lp-A-I:A-II. Furthermore, subjects with PAD on statin medications have a more favorable risk profile, particularly noted in multiple apolipoprotein subparticles. The efficacy of statin therapy to improve cardiovascular risk appears more evident in the apolipoprotein sub-particle profile than in the more traditional lipid profile of subjects with PAD and claudication. This trial is registered with ClinicalTrials.govNCT00618670.

Abstract 17026: Effects of Supervised Exercise Therapy on Free-Living Physical Activity Among Patients With Symptomatic Peripheral Artery Disease

Circulation ◽  
2018 ◽  
Vol 138 (Suppl_1) ◽  
Author(s):  
Erica Schorr ◽  
Mary Whipple ◽  
Diane Treat-Jacobson
Keyword(s):  
Physical Activity ◽  
Peripheral Artery Disease ◽  
Exercise Therapy ◽  
Sedentary Time ◽  
Peripheral Artery ◽  
Activity Tracking ◽  
Free Living ◽  
Supervised Exercise ◽  
Artery Disease ◽  
Tracking Devices

Introduction: Evidence supporting the effects of supervised exercise therapy (SET) on alleviating symptoms and improving walking ability for patients with symptomatic peripheral artery disease (PAD) is robust and well recognized. However, little is known about the impact of SET on free-living physical activity (PA). The aim of this study was to examine the relationship between participation in SET and changes in free-living PA among individuals in the the EX ercise Training to Reduce Claudication: Arm ER gometry versus T readmill Walking ( EXERT ) trial. Methods: In this randomized, controlled trial, 104 participants (mean age 68±9; 29% female) were allocated to receive treadmill (TM) exercise (n=41), upper body ergometry (UBE) exercise (n=42), or usual-care (UC) (n=21) for 12 weeks. Exercise participants attended SET three times per week; UC participants met with study staff weekly. PA was measured over 7 days via waist-worn ActiGraph accelerometers at baseline, 6, and 12 weeks. Steps per day was the primary outcome. Secondary outcomes were proportion of time in light and moderate to vigorous physical activity (MVPA), and sedentary time. PA was controlled for in TM participants by using SET logs. Results were analyzed using descriptive statistics, two-sample t-tests, and analysis of variance. Results: Regardless of randomization, average daily steps were low at baseline and 6 weeks (4,013 steps, p =.72; and 3,911 steps, p =.84, respectively), and slightly higher at 12 weeks (4,307 steps; p =.93). Although not statistically significant but perhaps clinically relevant, UBE participants exhibited greater increases in MVPA over 12 weeks (0.9% to 1.3%; F =.48, p =.62) compared to TM (1.2% to 1.3%; F =.35, p =.71) and UC (1.3% to 1.5%, F =.03, p =.97); similarly all participants exhibited reductions in sedentary time and increases in free-living PA between baseline and 12 weeks. Conclusions: These data suggest individuals with PAD attending SET replace sedentary time with light or moderate intensity PA regardless of exercise modality. Despite study participants meeting the recommended daily steps for adults with chronic conditions (3,500-5,500 steps), it is suspected that they did not reach the daily goal of 30 minutes of enhanced PA to reduce health risks. Future research should incorporate activity tracking devices that can provide feedback on PA as an approach to meet daily PA goals. Activity tracking devices used in conjunction with SET may further improve walking distance, symptom management, and quality of life among patients with symptomatic PAD.

scholarly journals Leg heat therapy improves perceived physical function but does not enhance walking capacity or vascular function in patients with peripheral artery disease

2020 ◽  
Vol 129 (6) ◽  
pp. 1279-1289
Author(s):  
Jacob C. Monroe ◽  
Chen Lin ◽  
Susan M. Perkins ◽  
Yan Han ◽  
Brett J. Wong ◽  
...  
Keyword(s):  
Physical Function ◽  
Peripheral Artery Disease ◽  
Vascular Function ◽  
Controlled Study ◽  
Peripheral Artery ◽  
Walking Capacity ◽  
Heat Therapy ◽  
Walking Performance ◽  
Artery Disease ◽  
Potent Vasoconstrictor

This is the first sham-controlled study to investigate the effects of leg heat therapy (HT) on walking performance, vascular function, and quality of life in patients with peripheral artery disease (PAD). Adherence to HT was high, and the treatment was well tolerated. Our findings revealed that HT applied with water-circulating trousers evokes a clinically meaningful increase in perceived physical function and reduces the serum concentration of the potent vasoconstrictor endothelin-1 in patients with PAD.

scholarly journals Physical activity and peripheral artery disease: Two prospective cohort studies and a systematic review

2019 ◽  
Vol 286 ◽  
pp. 114-120 ◽  
Author(s):  
Katriina Heikkilä ◽  
Patrick A. Coughlin ◽  
Jaana Pentti ◽  
Mika Kivimäki ◽  
Jaana I. Halonen
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Cohort Studies ◽  
Peripheral Artery Disease ◽  
Prospective Cohort ◽  
Peripheral Artery ◽  
Prospective Cohort Studies ◽  
Artery Disease

Evaluation of the clinical relevance and limitations of current pre-clinical models of peripheral artery disease

2015 ◽  
Vol 130 (3) ◽  
pp. 127-150 ◽  
Author(s):  
Smriti Murali Krishna ◽  
Safraz Mohamed Omer ◽  
Jonathan Golledge
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Animal Models ◽  
Peripheral Artery Disease ◽  
Clinical Relevance ◽  
Peripheral Artery ◽  
Advantages And Disadvantages ◽  
Clinical Models ◽  
Artery Disease

Peripheral artery disease (PAD) has recognized treatment deficiencies requiring the discovery of novel interventions. This article describes current animal models of PAD and discusses their advantages and disadvantages. There is a need for models which more directly simulate the characteristics of human PAD, such as acute-on-chronic presentation, presence of established risk factors and impairment of physical activity.

Effects of Clustered Comorbid Conditions on Walking Capacity in Patients with Peripheral Artery Disease

2014 ◽  
Vol 28 (2) ◽  
pp. 279-283 ◽  
Author(s):  
Breno Quintella Farah ◽  
Raphael Mendes Ritti-Dias ◽  
Gabriel Grizzo Cucato ◽  
Marcel da Rocha Chehuen ◽  
João Paulo dos Anjos Souza Barbosa ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Comorbid Conditions ◽  
Peripheral Artery ◽  
Walking Capacity ◽  
Artery Disease
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