Does blood flow restriction result in skeletal muscle damage? A critical review of available evidence

2014 ◽  
Vol 24 (6) ◽  
pp. e415-422 ◽  
Author(s):  
J. P. Loenneke ◽  
R. S. Thiebaud ◽  
T. Abe
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Muscle Damage ◽  
Critical Review ◽  
Blood Flow Restriction ◽  
Skeletal Muscle Damage ◽  
Flow Restriction

scholarly journals Effects of combined treatment with blood flow restriction and low-current electrical stimulation on muscle hypertrophy in rats

2019 ◽  
Vol 127 (5) ◽  
pp. 1288-1296
Author(s):  
Madoka Yoshikawa ◽  
Takeshi Morifuji ◽  
Tomohiro Matsumoto ◽  
Noriaki Maeshige ◽  
Minoru Tanaka ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Electrical Stimulation ◽  
Muscle Hypertrophy ◽  
Combined Treatment ◽  
Blood Flow Restriction ◽  
Sectional Area ◽  
Cross Sectional ◽  
Flow Restriction ◽  
Skeletal Muscle Hypertrophy

This study aimed to clarify the effects of a combined treatment comprising blood flow restriction and low-current electrical stimulation on skeletal muscle hypertrophy in rats. Male Wistar rats were divided into control (Cont), blood flow restriction (Bfr), electrical stimulation (Es), or Bfr with Es (Bfr + Es) groups. Pressure cuffs (80 mmHg) were placed around the thighs of Bfr and Bfr + Es rats. Low-current Es was applied to calf muscles in the Es and Bfr + Es rats. In experiment 1, a 1-day treatment regimen (5-min stimulation, followed by 5-min rest) was delivered four times to study the acute effects. In experiment 2, the same treatment regimen was delivered three times/wk for 8 wk. Body weight, muscle mass, changes in maximal isometric contraction, fiber cross-sectional area of the soleus muscle, expression of phosphorylated and total-ERK1/2, phosphorylated-rpS6 Ser235/236, phosphorylated and total Akt, and phosphorylated-rpS6 Ser240/244 were measured. Bfr and Es treatment alone failed to induce muscle hypertrophy and increase the expression of phosphorylated rpS6 Ser240/244. Combined Bfr + Es upregulated muscle mass, increased the fiber cross-sectional area, and increased phosphorylated rpS6 Ser240/244 expression and phosphorylated rpS6 Ser235/236 expression compared with controls. Combined treatment with Bfr and low-current Es can induce muscle hypertrophy via activation of two protein synthesis signaling pathways. This treatment should be introduced for older patients with sarcopenia and others with muscle weakness. NEW & NOTEWORTHY We investigated the acute and chronic effect of low-current electrical stimulation with blood flow restriction on skeletal muscle hypertrophy and the mechanisms controlling the hypertrophic response. Low-current electrical stimulation could not induce skeletal muscle hypertrophy, but a combination treatment did. Blood lactate and growth hormone levels were increased in the early response. Moreover, activation of ERK1/2 and mTOR pathways were observed in both the acute and chronic response, which contribute to muscle hypertrophy.

Does a resistance exercise session with continuous or intermittent blood flow restriction promote muscle damage and increase oxidative stress?

2017 ◽  
Vol 36 (1) ◽  
pp. 104-110 ◽  
Author(s):  
Gabriel R. Neto ◽  
Jefferson S. Novaes ◽  
Verônica P. Salerno ◽  
Michel M. Gonçalves ◽  
Gilmário R. Batista ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Flow ◽  
Resistance Exercise ◽  
Muscle Damage ◽  
Blood Flow Restriction ◽  
Exercise Session ◽  
Flow Restriction ◽  
Resistance Exercise Session

scholarly journals The effects of practical vascular blood flow restriction training on skeletal muscle hypertrophy

2014 ◽  
Vol 11 (Suppl 1) ◽  
pp. P18 ◽  
Author(s):  
John O'Halloran ◽  
Bill Campbell ◽  
Nicholas Martinez ◽  
Shane O’Connor ◽  
Jonathan Fuentes ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Muscle Hypertrophy ◽  
Blood Flow Restriction ◽  
Flow Restriction ◽  
Skeletal Muscle Hypertrophy
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