The ADH gene cluster SNP rs1789891 and temperamental dimensions in patients with alcohol dependence and affective disorders

2015 ◽  
Vol 56 (4) ◽  
pp. 420-427 ◽  
Author(s):  
Włodzimierz Oniszczenko ◽  
Janusz K. Rybakowski ◽  
Wojciech Ł. Dragan ◽  
Anna Grzywacz ◽  
Jerzy Samochowiec
Keyword(s):  
Alcohol Dependence ◽  
Gene Cluster ◽  
Affective Disorders ◽  
Adh Gene

scholarly journals Diplotype Trend Regression Analysis of the ADH Gene Cluster and the ALDH2 Gene: Multiple Significant Associations with Alcohol Dependence

2006 ◽  
Vol 78 (6) ◽  
pp. 973-987 ◽  
Author(s):  
Xingguang Luo ◽  
Henry R. Kranzler ◽  
Lingjun Zuo ◽  
Shuang Wang ◽  
Nicholas J. Schork ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Alcohol Dependence ◽  
Gene Cluster ◽  
Adh Gene ◽  
Aldh2 Gene

scholarly journals Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster

2011 ◽  
Vol 17 (1) ◽  
pp. 171-180 ◽  
Author(s):  
Josef Frank ◽  
Sven Cichon ◽  
Jens Treutlein ◽  
Monika Ridinger ◽  
Manuel Mattheisen ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Gene Cluster ◽  
Genome Wide ◽  
Adh Gene

scholarly journals PIP5K2A (rs10828317) polymorphism in patients with alcohol dependence and affective disorders

2021 ◽  
Vol 13 (3) ◽  
pp. 48-52
Author(s):  
E. V. Mikhalitskaya ◽  
N. M. Vyalova ◽  
O. Yu. Fedorenko ◽  
O. V. Roshchina ◽  
G. G. Simutkin ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Conformational Changes ◽  
Affective Disorders ◽  
Rating Scale ◽  
Modern Society ◽  
Structured Interview ◽  
Depression Symptoms ◽  
Obsessive Compulsive ◽  
Atypical Depression ◽  
Phosphatidylinositol 4

Alcohol dependence (AD) and affective disorders (ADs) are serious medical and socio-economic problems of modern society. It is hypothesized that both disorders share a common neurobiological basis. Phosphatidylinositol-4-phosphate-5-kinase type 2 alpha (PIP5K2A) plays an essential role in neuronal phosphoinositide signaling pathways. Nonsynonymous rs10828317 mutation of the PIP5K2A gene leads to conformational changes of the PIP5K2A protein and a decrease in the functional activity of this enzyme. In this study, we assessed the possibility of using the rs10828317 polymorphic variant of the PIP5K2A gene as a marker of AD and ADs.Objective: to study the associations of the PIP5K2A (rs10828317) polymorphism with AD and ADs clinical course.Patients and methods. We enrolled 255 patients with AD and 325 patients with ADs. 126 patients with AD and 71 patients with ADs underwent a comprehensive clinical, clinical-dynamic, psychodiagnostic assessment using a set of clinical scales and tests, including Structured Interview Guide For The Hamilton Depression Rating Scale, Seasonal Affective Disorders Version (SIGH-SAD), Alcohol Use Disorders Identification Test (AUDIT), The Obsessive-Compulsive Drinking Scale for craving in alcohol (OCDS).Results and discussion. PIP5K2A (rs10828317) polymorphism in patients with AD was associated with the OCDS mean score after the inpatient treatment; in patients with ADs - with the severity of atypical depression symptoms assessed by SIGH-SAD at the time of admission.Conclusion. The results of our pilot study indicate the involvement of PIP5K2A (rs10828317) polymorphism in the AD and ADs pathophysiology.

scholarly journals Association between variants at the GABAAβ2, GABAAα6 and GABAAγ2 gene cluster and alcohol dependence in a Scottish population

1999 ◽  
Vol 4 (6) ◽  
pp. 539-544 ◽  
Author(s):  
E-W Loh ◽  
I Smith ◽  
R Murray ◽  
M McLaughlin ◽  
S McNulty ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Gene Cluster ◽  
Scottish Population

Association Analysis of Sequence Variants of the GABAA alpha6, beta2, and gamma2 Gene Cluster and Alcohol Dependence

1999 ◽  
Vol 23 (3) ◽  
pp. 427-431 ◽  
Author(s):  
Thomas Sander ◽  
David Ball ◽  
Robin Murray ◽  
Jaimin Patel ◽  
Jerzy Samochowiec ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Gene Cluster ◽  
Association Analysis ◽  
Sequence Variants

Affective Disorders with or Without Comorbid Alcohol Dependence: a Longitudinal Neuropsychological and Neuroimaging Investigation in Young Adults

2015 ◽  
Vol 30 ◽  
pp. 1238
Author(s):  
R.S.C. Lee ◽  
G. Dore ◽  
L. Juckes ◽  
J. Lagopoulos ◽  
S. Hatton ◽  
...  
Keyword(s):  
Young Adults ◽  
Alcohol Dependence ◽  
Affective Disorders

Clinical-Dynamic Features of Affective Disorders Comorbid with Alcohol Dependence

2020 ◽  
Author(s):  
Svetlana N. Vasilieva ◽  
German G. Simutkin ◽  
Evgeny D. Schastnyy ◽  
Nikolay A. Bokhan
Keyword(s):  
Alcohol Dependence ◽  
Affective Disorders ◽  
Dynamic Features
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