The clinical and prognostic significance of CD14 (+) HLA‐DR (‐/low) myeloid‐derived suppressor cells in patients with hepatocellular carcinoma received transarterial radioembolization with Yttrium‐90

2021 ◽  
Author(s):  
Barış Boral ◽  
Hüseyin Tuğsan Ballı ◽  
Sinan Sözütok ◽  
Umur Anıl Pehlivan ◽  
Kairgeldy Aikimbaev
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Significance ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Transarterial Radioembolization ◽  
Hla Dr ◽  
Yttrium 90

Increased circulating Lin−/lowCD33+HLA-DR−myeloid-derived suppressor cells in hepatocellular carcinoma patients

2013 ◽  
Vol 44 (6) ◽  
pp. 639-650 ◽  
Author(s):  
Peng Shen ◽  
Aijuan Wang ◽  
Mengye He ◽  
Qingqing Wang ◽  
Shusen Zheng
Keyword(s):  
Hepatocellular Carcinoma ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Hla Dr

scholarly journals Increase in CD14+HLA-DR−/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis

2013 ◽  
Vol 62 (8) ◽  
pp. 1421-1430 ◽  
Author(s):  
Fumitaka Arihara ◽  
Eishiro Mizukoshi ◽  
Masaaki Kitahara ◽  
Yoshiko Takata ◽  
Kuniaki Arai ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Hla Dr

Circulating CD14+ HLA-DR−/low myeloid-derived suppressor cells predicted early recurrence of hepatocellular carcinoma after surgery

2017 ◽  
Vol 47 (10) ◽  
pp. 1061-1071 ◽  
Author(s):  
Xing-Hui Gao ◽  
Lu Tian ◽  
Jiong Wu ◽  
Xiao-Lu Ma ◽  
Chun-Yan Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Suppressor Cells ◽  
Early Recurrence ◽  
Myeloid Derived Suppressor Cells ◽  
Hla Dr

scholarly journals Myeloid phenotypes in severe COVID-19 predict secondary infection and mortality: a pilot study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Clémence Marais ◽  
Caroline Claude ◽  
Nada Semaan ◽  
Ramy Charbel ◽  
Simon Barreault ◽  
...  
Keyword(s):  
Critically Ill ◽  
Host Response ◽  
Secondary Infection ◽  
Myeloid Cells ◽  
Suppressor Cells ◽  
Human Leukocyte ◽  
Myeloid Derived Suppressor Cells ◽  
Phenotypic Characteristics ◽  
Leukocyte Antigen ◽  
Hla Dr

Abstract Background De-regulated host response to severe coronavirus disease 2019 (COVID-19), directly referring to the concept of sepsis-associated immunological dysregulation, seems to be a strong signature of severe COVID-19. Myeloid cells phenotyping is well recognized to diagnose critical illness-induced immunodepression in sepsis and has not been well characterized in COVID-19. The aim of this study is to review phenotypic characteristics of myeloid cells and evaluate their relations with the occurrence of secondary infection and mortality in patients with COVID-19 admitted in an intensive care unit. Methods Retrospective analysis of the circulating myeloid cells phenotypes of adult COVID-19 critically ill patients. Phenotyping circulating immune cells was performed by flow cytometry daily for routine analysis and twice weekly for lymphocytes and monocytes subpopulations analysis, as well as monocyte human leukocyte antigen (mHLA)-DR expression. Results Out of the 29 critically ill adult patients with severe COVID-19 analyzed, 12 (41.4%) developed secondary infection and six patients died during their stay. Monocyte HLA-DR kinetics was significantly different between patients developing secondary infection and those without, respectively, at day 5–7 and 8–10 following admission. The monocytes myeloid-derived suppressor cells to total monocytes ratio was associated with 28- and 60-day mortality. Those myeloid characteristics suggest three phenotypes: hyperactivated monocyte/macrophage is significantly associated with mortality, whereas persistent immunodepression is associated with secondary infection occurrence compared to transient immunodepression. Conclusions Myeloid phenotypes of critically ill COVID-19 patients may be associated with development of secondary infection, 28- and 60-day mortality.

scholarly journals Transarterial Radioembolization with Yttrium-90 for the Treatment of Hepatocellular Carcinoma

2016 ◽  
Vol 33 (5) ◽  
pp. 699-714 ◽  
Author(s):  
Joseph Ralph Kallini ◽  
Ahmed Gabr ◽  
Riad Salem ◽  
Robert J. Lewandowski
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transarterial Radioembolization ◽  
Yttrium 90
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