Functional immune reconstitution early after allogeneic haematopoietic cell transplantation: A comparison of pre‐ and post‐transplantation cytokine responses in stimulated whole blood

2021 ◽  
Author(s):  
Lars Klingen Gjærde ◽  
Patrick Terrence Brooks ◽  
Niels Smedegaard Andersen ◽  
Lone Smidstrup Friis ◽  
Brian Kornblit ◽  
...  
Keyword(s):  
Cell Transplantation ◽  
Whole Blood ◽  
Immune Reconstitution ◽  
Post Transplantation ◽  
Cytokine Responses ◽  
Haematopoietic Cell ◽  
Allogeneic Haematopoietic Cell Transplantation

scholarly journals Immune Reconstitution After Allogeneic Haematopoietic Cell Transplantation: From Observational Studies to Targeted Interventions

2022 ◽  
Vol 9 ◽  
Author(s):  
Asaf Yanir ◽  
Ansgar Schulz ◽  
Anita Lawitschka ◽  
Stefan Nierkens ◽  
Matthias Eyrich
Keyword(s):  
T Cells ◽  
Cell Transplantation ◽  
Immune Reconstitution ◽  
Immune Cell ◽  
Infectious Complications ◽  
Cell Recovery ◽  
Targeted Interventions ◽  
Post Transplant ◽  
Haematopoietic Cell ◽  
Allogeneic Haematopoietic Cell Transplantation

Immune reconstitution (IR) after allogeneic haematopoietic cell transplantation (HCT) represents a central determinant of the clinical post-transplant course, since the majority of transplant-related outcome parameters such as graft-vs.-host disease (GvHD), infectious complications, and relapse are related to the velocity, quantity and quality of immune cell recovery. Younger age at transplant has been identified as the most important positive prognostic factor for favourable IR post-transplant and, indeed, accelerated immune cell recovery in children is most likely the pivotal contributing factor to lower incidences of GvHD and infectious complications in paediatric allogeneic HCT. Although our knowledge about the mechanisms of IR has significantly increased over the recent years, strategies to influence IR are just evolving. In this review, we will discuss different patterns of IR during various time points post-transplant and their impact on outcome. Besides IR patterns and cellular phenotypes, recovery of antigen-specific immune cells, for example virus-specific T cells, has recently gained increasing interest, as certain threshold levels of antigen-specific T cells seem to confer protection against severe viral disease courses. In contrast, the association between IR and a possible graft-vs. leukaemia effect is less well-understood. Finally, we will present current concepts of how to improve IR and how this could change transplant procedures in the near future.

Allogeneic haematopoietic cell transplantation for patients with myelodysplastic syndrome (MDS)

2007 ◽  
Vol 33 ◽  
pp. S6-S10 ◽  
Author(s):  
Martin Bornhäuser ◽  
Uwe Platzbecker ◽  
Michelle Meredyth Stewart ◽  
Gerhard Ehninger
Keyword(s):  
Myelodysplastic Syndrome ◽  
Cell Transplantation ◽  
Haematopoietic Cell ◽  
Allogeneic Haematopoietic Cell Transplantation
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