A bacterial stimulation assay for bronchoalveolar lavage immune cells from young children with cystic fibrosis

2021 ◽  
Author(s):  
Haipei Liu ◽  
Sohinee Sarkar ◽  
Kristy Azzopardi ◽  
Sophie Day ◽  
Serene Yeow ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Young Children ◽  
Bronchoalveolar Lavage ◽  
Immune Cells ◽  
Bacterial Stimulation

scholarly journals Pseudomonas aeruginosa eradication therapy and risk of acquiring Aspergillus in young children with cystic fibrosis

Thorax ◽  
2019 ◽  
Vol 74 (8) ◽  
pp. 740-748 ◽  
Author(s):  
Sabariah Noor Harun ◽  
Nicholas H G Holford ◽  
Keith Grimwood ◽  
Claire E Wainwright ◽  
Stefanie Hennig
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Young Children ◽  
Bronchoalveolar Lavage ◽  
Eradication Therapy ◽  
Positive Culture ◽  
Cross Sectional ◽  
Cross Sectional Analysis ◽  
Increased Risk ◽  
Sectional Analysis

BackgroundWhile Aspergillus detection rates in adults, adolescents and older children with cystic fibrosis (CF) have increased, the risk of acquiring this fungal pathogen in young children is unknown.AimTo determine the risk and explanatory factors of acquiring Aspergillus in children with CF by age 5 years.MethodsCross-sectional analysis of clinical, bronchoalveolar lavage and treatment data from the Australasian Cystic Fibrosis Bronchoalveolar Lavage study was used to identify predictive factors for detecting Aspergillus at age 5 years. A parametric repeated time-to-event model quantitatively described the risk and factors associated with acquiring Aspergillus and Pseudomonas aeruginosa from birth until age 5 years.ResultsCross-sectional analysis found that the number of P. aeruginosa eradication courses increased the odds of detecting Aspergillus at age 5 years (OR 1.61, 95% CI 1.23 to 2.12). The median (IQR) age for the first P. aeruginosa positive culture was 2.38 (1.32–3.79) years and 3.69 (1.68–4.74) years for the first Aspergillus positive culture. The risk of P. aeruginosa and Aspergillus events changes with time after the first year of study entry. It also decreases for P. aeruginosa after completing P. aeruginosa eradication (HR 0.15, 95% CI 0.00 to 0.79), but increases for Aspergillus events (HR 2.75, 95% CI 1.45 to 5.41). The risk of acquiring both types of events increases after having had a previous event.ConclusionIn young children with CF, completing P. aeruginosa eradication therapy and previous Aspergillus events are associated with increased risk of acquiring Aspergillus.

Safety of bronchoalveolar lavage in young children with cystic fibrosis

2008 ◽  
Vol 43 (10) ◽  
pp. 965-972 ◽  
Author(s):  
Claire E. Wainwright ◽  
Keith Grimwood ◽  
John B. Carlin ◽  
Suzanna Vidmar ◽  
Peter J. Cooper ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Young Children ◽  
Bronchoalveolar Lavage

Regional differences in infection and structural lung disease in infants and young children with cystic fibrosis

2020 ◽  
Vol 19 (6) ◽  
pp. 917-922 ◽  
Author(s):  
Rosemary Carzino ◽  
Katherine B. Frayman ◽  
Louise King ◽  
Suzanna Vidmar ◽  
Sarath Ranganathan
Keyword(s):  
Cystic Fibrosis ◽  
Young Children ◽  
Lung Disease ◽  
Regional Differences ◽  
Infants And Young Children

Nontuberculous mycobacterial infection in young children with cystic fibrosis

2005 ◽  
Vol 40 (1) ◽  
pp. 39-44 ◽  
Author(s):  
Charles R. Esther ◽  
Marianna M. Henry ◽  
Paul L. Molina ◽  
Margaret W. Leigh
Keyword(s):  
Cystic Fibrosis ◽  
Young Children ◽  
Mycobacterial Infection ◽  
Nontuberculous Mycobacterial Infection
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