scholarly journals The monocyte locomotion inhibitory factor inhibits the expression of inflammation-induced cytokines following experimental contusion in rat tibia

2018 ◽  
Vol 88 (3) ◽  
pp. e12702 ◽  
Author(s):  
Sara Rojas-Dotor ◽  
Víctor Manuel Araujo-Monsalvo ◽  
Marco Julio Sánchez-Rojas ◽  
Víctor Manuel Domínguez-Hernández
Keyword(s):  
Inhibitory Factor ◽  
Rat Tibia ◽  
Monocyte Locomotion Inhibitory Factor

Monocyte Locomotion Inhibitory Factor confers neuroprotection and prevents the development of murine cerebral malaria

2021 ◽  
Vol 97 ◽  
pp. 107674
Author(s):  
A. Galán-Salinas ◽  
G. Corral-Ruíz ◽  
M.J. Pérez-Vega ◽  
L. Fabila-Castillo ◽  
R. Silva-García ◽  
...  
Keyword(s):  
Cerebral Malaria ◽  
Inhibitory Factor ◽  
Monocyte Locomotion Inhibitory Factor

Cytokine expression in CD4+ cells exposed to the monocyte locomotion inhibitory factor produced by Entamoeba histolytica

2005 ◽  
Vol 98 (5) ◽  
pp. 493-495 ◽  
Author(s):  
Sara Rojas-Dotor ◽  
Guadalupe Rico ◽  
Julia Pérez ◽  
Juan Velázquez ◽  
Raúl Silva ◽  
...  
Keyword(s):  
Entamoeba Histolytica ◽  
Cytokine Expression ◽  
Inhibitory Factor ◽  
Cd4 Cells ◽  
Monocyte Locomotion Inhibitory Factor

The Cys-Asn-Ser carboxyl-terminal end group is the pharmacophore of the amebic anti-inflammatory monocyte locomotion inhibitory factor (MLIF)

2008 ◽  
Vol 158 (1) ◽  
pp. 46-51 ◽  
Author(s):  
María Esther Morales-Martínez ◽  
Raúl Silva-García ◽  
Catalina Soriano-Correa ◽  
Juan Antonio Giménez-Scherer ◽  
Sara Rojas-Dotor ◽  
...  
Keyword(s):  
Inhibitory Factor ◽  
Inflammatory Monocyte ◽  
Carboxyl Terminal ◽  
Anti Inflammatory ◽  
Monocyte Locomotion Inhibitory Factor ◽  
End Group

Further characterization of a human monocyte locomotion inhibitory factor produced by axenically grownEntamoeba histolytica

1989 ◽  
Vol 75 (3) ◽  
pp. 245-246 ◽  
Author(s):  
R. R. Kretschmer ◽  
E. M. Castro ◽  
G. Rico ◽  
G. Pacheco ◽  
R. Noriega ◽  
...  
Keyword(s):  
Human Monocyte ◽  
Inhibitory Factor ◽  
Monocyte Locomotion Inhibitory Factor

scholarly journals Effect of the monocyte locomotion inhibitory factor (MLIF) produced by E. histolityca on cytokines and chemokine receptors in T CD4+ lymphocytes

2009 ◽  
Vol 42 (4) ◽  
Author(s):  
SARA ROJAS-DOTOR ◽  
JULIA PÉREZ-RAMOS ◽  
JUAN ANTONIO GIMÉNEZ-SCHERER ◽  
FRANCISCO BLANCO-FAVELA ◽  
GUADALUPE RICO-ROSILLO
Keyword(s):  
Chemokine Receptors ◽  
Inhibitory Factor ◽  
Monocyte Locomotion Inhibitory Factor ◽  
Cd4 Lymphocytes

scholarly journals Monocyte Locomotion Inhibitory Factor Produced byE. histolyticaImproves Motor Recovery and Develops Neuroprotection after Traumatic Injury to the Spinal Cord

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Gabriela Bermeo ◽  
Antonio Ibarra ◽  
Elisa García ◽  
Adrian Flores-Romero ◽  
Guadalupe Rico-Rosillo ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Spinal Cord ◽  
Lipid Peroxidation ◽  
Transforming Growth Factor ◽  
Ventral Horn ◽  
Motor Recovery ◽  
Inhibitory Factor ◽  
Neuroprotective Effects ◽  
Rubrospinal Tract ◽  
Monocyte Locomotion Inhibitory Factor

Monocyte locomotion inhibitory factor (MLIF) is a pentapeptide produced byEntamoeba histolyticathat has a potent anti-inflammatory effect. Either MLIF or phosphate buffered saline (PBS) was administered directly onto the spinal cord (SC) immediately after injury. Motor recovery was evaluated. We also analyzed neuroprotection by quantifying the number of surviving ventral horn motor neurons and the persistence of rubrospinal tract neurons. To evaluate the mechanism through which MLIF improved the outcome of SC injury, we quantified the expression of inducible nitric oxide synthase (iNOS), interleukin-10 (IL-10), and transforming growth factor-β(TGF-β) genes at the site of injury. Finally, the levels of nitric oxide and of lipid peroxidation were also determined in peripheral blood. Results showed that MLIF improved the rate of motor recovery and this correlated with an increased survival of ventral horn and rubrospinal neurons. These beneficial effects were in turn associated with a reduction in iNOS gene products and a significant upregulation of IL-10 and TGF-βexpression. In the same way, MLIF reduced the concentration of nitric oxide and the levels of lipid peroxidation in systemic circulation. The present results demonstrate for the first time the neuroprotective effects endowed by MLIF after SC injury.

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