Association of Interleukin 10 Gene Polymorphisms with Autoimmune Thyroid Disease: Meta-Analysis

2016 ◽  
Vol 84 (5) ◽  
pp. 272-277 ◽  
Author(s):  
J. H. Jung ◽  
G. G. Song ◽  
J-H. Kim ◽  
S. J. Choi
Keyword(s):  
Thyroid Disease ◽  
Gene Polymorphisms ◽  
Autoimmune Thyroid Disease ◽  
Meta Analysis ◽  
Interleukin 10 ◽  
Autoimmune Thyroid

scholarly journals Cytotoxic T-Lymphocyte Associated Antigen 4 Gene Polymorphisms and Autoimmune Thyroid Disease: A Meta-Analysis

2007 ◽  
Vol 92 (8) ◽  
pp. 3162-3170 ◽  
Author(s):  
Fotini K. Kavvoura ◽  
Takashi Akamizu ◽  
Takuya Awata ◽  
Yoshiyuki Ban ◽  
Dimitry A. Chistiakov ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Thyroid Disease ◽  
Gene Polymorphisms ◽  
Autoimmune Thyroid Disease ◽  
Cytotoxic T Lymphocyte ◽  
Meta Analysis ◽  
Autoimmune Thyroid

scholarly journals Analysis of expression and function of the inhibitory receptor ILT2 in lymphocytes from patients with autoimmune thyroid disease

2011 ◽  
Vol 165 (1) ◽  
pp. 129-136 ◽  
Author(s):  
Lesly Doníz-Padilla ◽  
Amalia E Paniagua ◽  
Pilar Sandoval-Correa ◽  
Adriana Monsiváis-Urenda ◽  
Susanna Leskela ◽  
...  
Keyword(s):  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Cell Cycle Progression ◽  
Mononuclear Cells ◽  
Thyroid Tissue ◽  
Interleukin 10 ◽  
Regulatory Function ◽  
Peripheral Blood Mononuclear ◽  
Autoimmune Thyroid ◽  
And Function

ObjectiveAutoimmune thyroid disease (AITD) is characterized by different defects in immunoregulatory mechanisms. The immunoglobulin-like transcript receptor 2 (ILT2) or leukocyte Ig-like receptor 1 (LIRB1/CD85j) exerts an important immunoregulatory role. We hypothesized that the lymphocytes from AITD patients have a diminished expression and function of ILT2. The aim of this study was to investigate the expression and function of ILT2 in lymphocytes from patients with AITD.Design and methodsIn this study, 18 patients with Hashimoto's thyroiditis (HT), 20 with Graves' disease, and 26 healthy controls were studied. ILT2 expression was analyzed by flow cytometry and immunohistochemistry in peripheral blood mononuclear cells (PBMC) and thyroid tissue. The regulatory function of ILT2 was assessed by an assay of inhibition of lymphocyte proliferation and by an analysis of cell cycle progression. The effect of ILT2 on cytokine synthesis was also evaluated.ResultsWe found a significant increased expression of ILT2 by lymphocytes in AITD patients. ILT2 was also detected in the leukocyte infiltrate of thyroid tissue from HT patients. On the contrary, a significant diminished inhibitory activity of ILT2 on cell proliferation was observed in AITD patients. In addition, PBMC from AITD patients showed a diminished synthesis of interleukin 10 on ILT2 engagement.ConclusionsThe abnormal expression and function of ILT2 detected in AITD suggests that this receptor may participate in the pathogenesis of this condition.

scholarly journals Variants of Interleukin-22 Gene Confer Predisposition to Autoimmune Thyroid Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Rong-hua Song ◽  
Qian Li ◽  
Wen Wang ◽  
Qiu-ming Yao ◽  
Xiao-qing Shao ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Thyroid Disease ◽  
Gene Polymorphisms ◽  
Autoimmune Thyroid Disease ◽  
Direct Sequencing ◽  
Autoimmune Thyroid ◽  
Interleukin 22 ◽  
Sequencing Method ◽  
Thyroid Associated Ophthalmopathy ◽  
Direct Sequencing Method

As there are no previous studies on the interleukin-22 (IL-22) variants in autoimmune thyroid disease (AITD), the present study aimed to explore the association between polymorphisms of IL-22 and the predisposition to AITD. The study had 975 AITD patients, including 639 Graves’ disease (GD) and 336 Hashimoto’s thyroiditis (HT) individuals and 851 healthy cohorts. Ligase detection reaction (LDR) and direct sequencing method were used for genotyping the IL-22 gene polymorphisms at rs2046068, rs2227478, rs2227485, rs11611206, and rs1179251. In comparison to female controls, genotype CC of rs1179251 was increased in the female AITD patients. Alleles C at rs2046068, C at rs2227478, and C at rs1179251 linked to the susceptibility of HT males. Genotype CC in rs1179251 was higher in male HT. Variants at rs2046068, rs2227478, and rs1179251 were associated with the AITD teenagers. Besides, genotype GG in rs11611206 was correlated with thyroid-associated ophthalmopathy (TAO). Moreover, allele G at rs11611206 was associated with decreased risk for TAO by 28.9%. Similarly, genotype CC of rs1179251 and genotype GG of rs11611206 were associated with Graves’ ophthalmopathy (GO). Allele G in rs11611206 increased people with HT towards the predisposition of hypothyroidism. In conclusion, genetic variants of IL-22 are associated with the occurrence of AITD.

scholarly journals Meta-Analysis of the Association between Vitamin D Receptor Polymorphisms and the Risk of Autoimmune Thyroid Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-15 ◽  
Author(s):  
Xue-Ren Gao ◽  
Yong-Guo Yu
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Meta Analysis ◽  
Autoimmune Thyroid ◽  
Asian Populations ◽  
Increased Risk ◽  
African Populations ◽  
Reduced Risk

The association between vitamin D receptor (VDR) polymorphisms (rs731236, rs1544410, rs2228570, and rs7975232) and the risk of autoimmune thyroid disease (AITD) had been investigated in previous studies. However, the results of these studies remained controversial. Thus, a meta-analysis was performed to derive a more precise conclusion. All related articles were systematically searched by PubMed, Embase, Google Scholar, and Chinese National Knowledge Infrastructure (CNKI). The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of association. The overall results indicated thatVDRrs731236 and rs2228570 polymorphisms were significantly associated with a reduced risk of AITD. However, a stratification analysis based on clinical types showed thatVDRrs731236 and rs2228570 polymorphisms were associated only with a reduced risk of HT. A stratification analysis by ethnicity showed thatVDRrs731236 polymorphism was significantly associated with a reduced risk of AITD in Asian and African populations.VDRrs2228570 polymorphism was associated with a reduced risk of AITD in Asian populations.VDRrs1544410 polymorphism was associated with a reduced risk of AITD in European and African populations, but with an increased risk of AITD in Asian populations.VDRrs7975232 polymorphism was significantly associated with an increased risk of AITD in African populations. In conclusion, the present study suggested thatVDRrs731236, rs1544410, rs2228570, and rs7975232 polymorphisms were significantly associated with AITD risk. However, more well-designed studies should be performed to verify the current results.

scholarly journals The proportion of peripheral blood Tregs among the CD4+ T cells of autoimmune thyroid disease patients: a meta-analysis

2020 ◽  
Vol 67 (3) ◽  
pp. 317-326 ◽  
Author(s):  
Ziyi Chen ◽  
Yue Wang ◽  
Xi Ding ◽  
Meng Zhang ◽  
Mingqian He ◽  
...  
Keyword(s):  
T Cells ◽  
Peripheral Blood ◽  
Thyroid Disease ◽  
Cd4 T Cells ◽  
Autoimmune Thyroid Disease ◽  
Meta Analysis ◽  
Autoimmune Thyroid

scholarly journals Association of IL-1β, NLRP3, and COX-2 Gene Polymorphisms with Autoimmune Thyroid Disease Risk and Clinical Features in the Iranian Population

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Zahra Heidari ◽  
Saeedeh Salimi ◽  
Mohsen Rokni ◽  
Mahnaz Rezaei ◽  
Neshat Khalafi ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Clinical Features ◽  
Significant Relationship ◽  
Thyroid Disease ◽  
Gene Polymorphisms ◽  
Autoimmune Thyroid Disease ◽  
Control Group ◽  
Autoimmune Thyroid ◽  
Cox 2 ◽  
Development Risk

Background. Grave’s disease (GD) and Hashimoto’s thyroiditis (HT) are autoimmune diseases of the thyroid gland in which genetic predisposition plays a major role in their development. Currently, the role of NLRP3 inflammasome and COX-2 has been documented in many autoimmune diseases. The purpose of the study is to delineate the impact of IL-1β (rs1143634), NLRP3 (rs3806265), and COX-2 (rs2745557) gene polymorphisms in the development of GD and HT. Methods. A total of 256 newly diagnosed patients with autoimmune thyroid disease (135 patients with HT and 121 GD patients) as case groups and 145 controls were included in the study. Results. Recessive and overdominant models showed a significant association between IL-1β rs1143634 SNP and HT development risk. The frequency of TT genotype and T allele of IL-1β rs1143634 SNP in the control group was significantly higher than the GD group. There was no significant association between NLRP3 rs3806265 polymorphism and HT and GD development. The frequency of GA genotype of COX-2 (rs2745557) in the control group was significantly higher than that in the HT group. There was no significant association between COX-2 rs2745557 genotypic and allelic distribution and GD development risk. The results revealed a significant relationship between some clinical features of HT and GD groups and SNPs studied. Conclusion. The results manifest the significant impact of IL-1β rs1143634 and COX-2 (rs2745557) SNPs and HT development and IL-1β rs1143634 SNP on GD occurrence risk. Furthermore, a significant relationship was observed between some clinical features of HT and GD groups and studied SNPs.

Prevalence of Celiac Disease in Patients with Autoimmune Thyroid Disease: A Meta-Analysis

Thyroid ◽  
2016 ◽  
Vol 26 (7) ◽  
pp. 880-890 ◽  
Author(s):  
Abhik Roy ◽  
Monika Laszkowska ◽  
Johan Sundström ◽  
Benjamin Lebwohl ◽  
Peter H.R. Green ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Meta Analysis ◽  
Autoimmune Thyroid

Increases of CD80 and CD86 Expression on Peripheral Blood Cells and their Gene Polymorphisms in Autoimmune Thyroid Disease

2019 ◽  
Vol 49 (1-2) ◽  
pp. 191-203 ◽  
Author(s):  
Ayano Watanabe ◽  
Naoya Inoue ◽  
Mikio Watanabe ◽  
Mayu Yamamoto ◽  
Haruka Ozaki ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Thyroid Disease ◽  
Blood Cells ◽  
Gene Polymorphisms ◽  
Autoimmune Thyroid Disease ◽  
Peripheral Blood Cells ◽  
Autoimmune Thyroid
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