scholarly journals Clinical Significance of Myeloid-Derived Suppressor Cells in Human Immunodeficiency Virus-1/ Hepatitis C Virus-coinfected Patients

2016 ◽  
Vol 83 (6) ◽  
pp. 438-444 ◽  
Author(s):  
A. H. Lei ◽  
Q. Yang ◽  
W. P. Cai ◽  
Y. F. Liu ◽  
Y. Lan ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Clinical Significance ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Immunodeficiency Virus ◽  
Human Immunodeficiency Virus 1

Seroprevalence of Human Immunodeficiency Virus-1, Hepatitis B Virus, and Hepatitis C Virus in Patients Having Major Surgery

1995 ◽  
Vol 16 (11) ◽  
pp. 627-632 ◽  
Author(s):  
Marisa A. Montecalvo ◽  
M. Sung Lee ◽  
Helene DePalma ◽  
Pe Shein Wynn ◽  
Albert B. Lowenfels ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Major Surgery ◽  
B Virus ◽  
Immunodeficiency Virus ◽  
Human Immunodeficiency Virus 1

scholarly journals Analysis of Monocytic and Granulocytic Myeloid-Derived Suppressor Cells Subsets in Patients with Hepatitis C Virus Infection and Their Clinical Significance

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Gang Ning ◽  
Lanhui She ◽  
Lirong Lu ◽  
Ying Liu ◽  
Yingfu Zeng ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Clinical Significance ◽  
Suppressor Cells ◽  
Hcv Rna ◽  
Myeloid Derived Suppressor Cells ◽  
Hepatitis C Virus Infection ◽  
Cell Responses ◽  
Hla Dr ◽  
Healthy Donors

Myeloid-derived suppressor cells (MDSCs) have been shown to inhibit T-cell responses in many diseases, but, in hepatitis C virus (HCV) infected patients, MDSCs are still poorly studied. In this assay, we investigated the phenotype and frequency of two new populations of MDSCs denoted as monocytic and granulocytic MDSCs (M-MDSCs and G-MDSCs) in HCV infected patients and analyzed their clinical significance in these patients respectively. We found that the frequency of CD14+HLA-DR-/lowcells (M-MDSCs) from HCV infected patients (mean ± SE, 3.134% ± 0.340%) was significantly increased when compared to healthy controls (mean ± SE, 1.764% ± 0.461%) (Z= −2.438,P= 0.015), while there was no statistical difference between the frequency ofHLA-DR-/lowCD33+CD11b+CD15+(G-MDSCs) of HCV infected patients and healthy donors (0.201% ± 0.038% versus 0.096% ± 0.026%,P> 0.05), which suggested that HCV infection could cause the proliferation of M-MDSCs instead of G-MDSCs. Besides, we found that the frequency of M-MDSCs in HCV infected patients had certain relevance with age (r= 0.358,P= 0.003); patients older than 40 years old group (mean ± SE, 3.673% ± 0.456%) had a significantly higher frequency of M-MDSCs than that of age less than 40 years old group (mean ± SE, 2.363% ± 0.482%) (Z= −2.685,P= 0.007). The frequency of M-MDSCs, however, had no correlation with HCV RNA loads, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and the level of liver inflammation degree.

scholarly journals Trends for genetic variation of Hepatitis C Virus quasispecies in Human Immunodeficiency virus-1 coinfected patients

2007 ◽  
Vol 130 (1-2) ◽  
pp. 285-291 ◽  
Author(s):  
F. Xavier López-Labrador ◽  
Lorna Dove ◽  
Chee-Kin Hui ◽  
Yume Phung ◽  
Michael Kim ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Genetic Variation ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Immunodeficiency Virus ◽  
Human Immunodeficiency Virus 1
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