The Influence of Tonsillectomy on Total Serum Antibody Levels

2014 ◽  
Vol 80 (5) ◽  
pp. 377-379 ◽  
Author(s):  
G. Pidelaserra Martí ◽  
K. G. Isdahl Mohn ◽  
R. J. Cox ◽  
K. A. Brokstad
Keyword(s):  
Serum Antibody ◽  
Total Serum ◽  
Antibody Levels

scholarly journals COMPARATIVE ANALYSIS OF SERUM ANTIBODY RESPONSES TO H.PYLORI AND TO RECOMBINANT CAGA IN THE COHORT OF WORKING-AGE MOSCOW ADULTS

2018 ◽  
Vol 97 (9) ◽  
pp. 785-790 ◽  
Author(s):  
Ludmila V. Khripach ◽  
T. D. Knjazeva ◽  
S. M. Yudin ◽  
S. V. German ◽  
I. E. Zykova
Keyword(s):  
Lognormal Distribution ◽  
Serum Antibody ◽  
Bimodal Distribution ◽  
Antigenic Determinants ◽  
Total Serum ◽  
Serum Antibodies ◽  
Working Age ◽  
The Right ◽  
Genetically Determined ◽  
Antibody Levels

Introduction. Helicobacter pylori (Hр) is a helix-shaped bacterium adapted evolutionary to living in the mucoid of stomach. Considered usually as one of the factors in the development of gastritis, peptic ulcer and gastric cancer, but the opposite opinions were also discussed. The aim of this study was to assess levels of serum antibodies to Hp and recombinant CagA in the cohort of working-age Moscow adults. Methods. Commercial ELISA kits “IFA-Helicobacter IgG”© (ZAO EKOlab, Russia) and “HelicoBest-antibodies”© (ZAO Vector-Best, Russia) were applied for the estimation of serum antibodies to Hp and CagA, correspondingly, in the observed cohort (both gender adults, N=319). Results. 85 % of the human cohort (N=271) had positive rates of IgG-antibodies against complex Hp antigen, with lognormal distribution of IgG titers (median 1:688; Q1 - Q3 1:370 - 1:1223) and cut-off value equal to 1:100. 54 % of the human cohort (N=172) were seropositive to recombinant CagA, with the levels of total serum antibodies (IgM, IgA and IgG) from 23 to 129 elisa units (median 87,9; Q1 - Q3 56,7 - 102,5) and cut-off value equal to 18,5 EU. The distribtion of CagA antibody levels was sharply different from lognormal distribution of IgG titers to complex Hp antigen and had signs of bimodality with the main maximum shifted to the right. In the complete cohort under observation (N=319), the levels of serum antibodies to Hp and CagA were associated with a weak (R=0,217), but highly significant (p=0,00009) positive linkage; human persons, seropositive to both antigens, had no any association between the markers. Discussion. Possible reasons of differences in the shape of distributions of the studied markers are discussed. Taking into account the extraordinary genetic variability of natural Hp isolates, lognormal distribution of antibodies to complex Hp antigen can reflect combinatorial differences in the degree of proximity of Hp antigenic determinants between human persons under observation and the antigenic preparation. Bimodal distribution of antibody levels to individual protein CagA, possibly, reflect genetically determined differences in immunoreactivity inside the observed cohort.

Antibody response of carp, Cyprinus carpio to the cestode, Bothriocephalus acheilognathi

Parasitology ◽  
1999 ◽  
Vol 118 (6) ◽  
pp. 635-639 ◽  
Author(s):  
P. NIE ◽  
D. HOOLE
Keyword(s):  
Antibody Response ◽  
Cyprinus Carpio ◽  
Serum Antibody ◽  
Infected Fish ◽  
Immune Protection ◽  
Carp Cyprinus Carpio ◽  
Bothriocephalus Acheilognathi ◽  
Protection Against Infection ◽  
Antibody Levels ◽  
Antibody Secreting Cells

The humoral antibody response and the number of pronephric antibody-secreting cells were examined in naturally Bothriocephalus acheilognathi-infected carp. Cyprinus carpio, and in those injected intraperitoneally with an extract of the cestode. In the extract-injected fish, specific antibody was detected 3 weeks after a second injection given 2 weeks after the primary injection, and antibody levels persisted for more than 200 days. A third injection also enhanced the antibody level in the extract-injected carp. The numbers of antibody-secreting cells were significantly higher in carp injected 3 times with the extract than in the control. In naturally-infected fish, the serum antibody levels and the number of pronephric antibody-secreting cells were higher in infected fish than in uninfected individuals although this difference was not statistically significant. The relevance of these results to immune protection against infection is discussed.

scholarly journals Low Immunogenicity of Intravesical Phage Therapy for Urogenitary Tract Infections

Antibiotics ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 627
Author(s):  
Sławomir Letkiewicz ◽  
Marzanna Łusiak-Szelachowska ◽  
Ryszard Międzybrodzki ◽  
Maciej Żaczek ◽  
Beata Weber-Dąbrowska ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Bacterial Infections ◽  
Phage Therapy ◽  
Serum Antibody ◽  
Multidrug Resistant ◽  
Antibody Responses ◽  
Urogenital Infections ◽  
Reliable Model ◽  
Tract Infections ◽  
Antibody Levels

Patients with chronic urinary and urogenital multidrug resistant bacterial infections received phage therapy (PT) using intravesical or intravesical and intravaginal phage administration. A single course of PT did not induce significant serum antibody responses against administered phage. Whilst the second cycle of PT caused a significant increase in antibody levels, they nevertheless remained quite low. These data combined with good therapy results achieved in some patients suggest that this mode of PT may be an efficient means of therapy for urogenital infections and a reliable model for a clinical trial of PT.

Specific serum antibody levels and periodontal destruction.

1984 ◽  
Vol 19 (6) ◽  
pp. 614-617 ◽  
Author(s):  
H. K. Hrodek ◽  
R. Gmur ◽  
U. Saxlr ◽  
B. Guggenheim
Keyword(s):  
Serum Antibody ◽  
Specific Serum ◽  
Periodontal Destruction ◽  
Antibody Levels

scholarly journals Stability over Time of Serum Antibody Levels to Human Papillomavirus Type 16

1998 ◽  
Vol 177 (6) ◽  
pp. 1710-1714 ◽  
Author(s):  
Veronika af Geijersstam ◽  
Mari Kibur ◽  
Zhaohui Wang ◽  
Pentti Koskela ◽  
Eero Pukka la ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Serum Antibody ◽  
Human Papillomavirus Type 16 ◽  
Antibody Levels ◽  
Over Time

Study of Antibody Levels in Children with Purulent Otitis Media

1980 ◽  
Vol 89 (3_suppl) ◽  
pp. 117-120 ◽  
Author(s):  
P. Branefors ◽  
T. Dahlberg ◽  
O. Nylén
Keyword(s):  
Otitis Media ◽  
Serum Antibody ◽  
Acute Otitis Media ◽  
High Serum ◽  
Haemophilus Influenzae Type ◽  
Enzyme Linked Immunosorbent Assay ◽  
Polysaccharide Antigens ◽  
Antibody Titers ◽  
Iga Antibody ◽  
Antibody Levels

A series of episodes of acute otitis media were studied with reference to the bacterial findings in the nasopharynx and the specific antibody response in a group of children nine months to ten years of age, with previous frequent episodes of acute otitis media, Serum IgG, IgM and IgA antibody levels against five polysaccharide antigens, namely Haemophilus influenzae type b and Streptococcus pneumoniae types 3, 6, 19 and 23, were studied by means of an enzyme-linked immunosorbent assay. The selection of polysaccharide antigens was based on isolation frequency. The sera to be tested were tenfold serially diluted. An extinction of 0.2 over the base was taken as the end-point titer and expressed as in-log10. The results showed that most children including those under three years of age showed increasing homologous antibody titers at an infection, or had already initially very high antibody titers, especially of the IgG class. The titers reached levels of 104 to 105. In some cases, however, it could be shown that high serum antibody titers did not give protection against a new infection with the same serological type of bacteria. It was also demonstrated that most children, regardless of age, had IgG and IgM titers against the heterologous antigens. In some cases the levels were quite high (103 to 104). However, the IgA antibody levels were lower and in a considerable number of samples antibodies were not even detectable.

scholarly journals Longitudinal analysis of virus load, serum antibody levels and virus neutralizing activity in vitro in cases with less severe COVID-19

2020 ◽  
Author(s):  
Bertram Flehmig ◽  
Michael Schindler ◽  
Natalia Ruetalo ◽  
Ramona Businger ◽  
Manfred Bayer ◽  
...  
Keyword(s):  
Serum Antibody ◽  
Disease Onset ◽  
Igg Antibodies ◽  
Virus Load ◽  
Neutralizing Activity ◽  
N Protein ◽  
Life Threatening ◽  
Antibody Levels ◽  
The Relationship

Background: Patients infected with SARS-CoV-2 exhibit a highly variable clinical course, varying from barely discernible signs of disease, to moderate flu-like symptoms and, occasionally, with life-threatening pneumonia and/or cytokine storm. The relationship between the nasopharyngeal virus load, IgA and IgG antibodies to both the S1-RBD-protein and the N-protein as well the neutralizing activity (NAbs) against SARS-CoV-2 in the blood of moderately afflicted COVID-19 patients has not been investigated longitudinally so far. Methods: Several new serological methods to examine these parameters were developed and validated for the longitudinal investigation in three patients of a family which underwent a mild course of COVID-19. Findings: We observed that the virus load had almost completely disappeared after about four weeks, whereas serum antibodies showed a contrasting course. IgA levels to S1-RBD-protein and, to a lesser extent, to the N-protein, peaked about three weeks after clinical disease onset but declined soon thereafter. IgG levels rose continuously, reaching a plateau approximately six weeks after disease onset. NAbs in serum reached a peak about four weeks after disease onset but dropped to a lower level about six weeks later. Interpretation: Our data establishes associations of virus neutralization and a serological immune response foremost against Sars-CoV-2 S1-RDB-protein in a longitudinal manner.

scholarly journals Correlation of vaccine-elicited antibody levels and neutralizing activities against SARS-CoV-2 and its variants

2021 ◽  
Author(s):  
Jinbiao Liu ◽  
Brittany H Bodnar ◽  
Xu Wang ◽  
Peng Wang ◽  
Fengzhen Meng ◽  
...  
Keyword(s):  
Protective Efficacy ◽  
Serum Antibody ◽  
Specific Serum ◽  
Effective Immune Response ◽  
Serum Igg ◽  
High Level ◽  
Protection Against Infection ◽  
Antibody Levels ◽  
Serum Igg Levels ◽  
Igg Level

Both Pfizer-BNT162b2 and Moderna-mRNA-1273 vaccines can elicit an effective immune response against SARS-CoV-2 infection. However, the elicited serum antibody levels vary substantially and longitudinally decrease after vaccination. We examined the correlation of vaccination-induced IgG levels and neutralization titers against newly emerged variants remains and demonstrate a significant reduction of neutralization activities against the variants (B.1.1.7, B.1.525, and B.1.351) in Pfizer or Moderna vaccined sera. There was a significant and positive correlation between serum IgG levels and ID50 titers for not only SARS-CoV-2 WT but also the variants. These findings indicate that a high level of anti-spike IgG may offer better protection against infection from SARS-CoV-2 and its variants. Therefore, it is necessary to longitudinally monitor specific serum IgG level for evaluating the protective efficacy of the vaccines against SARS-CoV-2 and its new variants.

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