scholarly journals The Role of T cell Immunoglobulin and Mucin Domain-3 in Immune Thrombocytopenia

2014 ◽  
Vol 79 (4) ◽  
pp. 231-236 ◽  
Author(s):  
X.-M. Zhang ◽  
N.-N. Shan
Keyword(s):  
T Cell ◽  
Immune Thrombocytopenia ◽  
Domain 3

scholarly journals Tim3 binding to galectin-9 stimulates antimicrobial immunity

2010 ◽  
Vol 207 (11) ◽  
pp. 2343-2354 ◽  
Author(s):  
Pushpa Jayaraman ◽  
Isabel Sada-Ovalle ◽  
Sarah Beladi ◽  
Ana C. Anderson ◽  
Valerie Dardalhon ◽  
...  
Keyword(s):  
T Cell ◽  
Macrophage Activation ◽  
Th1 Cells ◽  
Th1 Cell ◽  
Cell Surface Molecule ◽  
Tissue Inflammation ◽  
Regulatory Molecule ◽  
Domain 3 ◽  
Antimicrobial Immunity

T cell immunoglobulin and mucin domain 3 (Tim3) is a negative regulatory molecule that inhibits effector TH1-type responses. Such inhibitory signals prevent unintended tissue inflammation, but can be detrimental if they lead to premature T cell exhaustion. Although the role of Tim3 in autoimmunity has been extensively studied, whether Tim3 regulates antimicrobial immunity has not been explored. Here, we show that Tim3 expressed on TH1 cells interacts with its ligand, galectin-9 (Gal9), which is expressed by Mycobacterium tuberculosis–infected macrophages to restrict intracellular bacterial growth. Tim3–Gal9 interaction leads to macrophage activation and stimulates bactericidal activity by inducing caspase-1–dependent IL-1β secretion. We propose that the TH1 cell surface molecule Tim3 has evolved to inhibit growth of intracellular pathogens via its ligand Gal9, which in turn inhibits expansion of effector TH1 cells to prevent further tissue inflammation.

scholarly journals Emerging role of stem cell memory-like T cell in immune thrombocytopenia

2019 ◽  
Vol 89 (3) ◽  
pp. e12739 ◽  
Author(s):  
Jiang Cao ◽  
Changxiao Zhang ◽  
Xiao Han ◽  
Hai Cheng ◽  
Wei Chen ◽  
...  
Keyword(s):  
Stem Cell ◽  
T Cell ◽  
Immune Thrombocytopenia ◽  
Cell Memory

Role of CD5 expression on TCRγδ T cell-differentiation and development of chronic intestinal inflammation

2001 ◽  
Vol 120 (5) ◽  
pp. A517-A517
Author(s):  
A MIZOGUCHI ◽  
E MIZOGUCHI ◽  
Y DEJONG ◽  
H TAKEDATSU ◽  
F PREFFER ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
Intestinal Inflammation ◽  
T Cell Differentiation ◽  
Chronic Intestinal Inflammation
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